| Outcome Measures: |
Primary: Absolute change from baseline to end of randomized treatment period in glycosylated hemoglobin A1c (HbA1c) | Secondary: Changes in the following variables from baseline to the end of the randomized treatment period:|• The change in fasting plasma glucose (FPG), insulin, proinsulin and C-peptide|• Insulin sensitivity by assessment of change in the calculated variable homeostasis assessment model|• Lipid parameters (triglyceride [TG], total cholesterol, high-density lipoprotein cholesterol [HDL C], non-HDL C, low-density lipoprotein cholesterol [LDL C], apolipoproteins [Apo] A-I, Apo B, Apo CIII, free fatty acids, lipoprotein particle size and c|• C-reactive protein, LDL C/HDL C ratio and Apo B/Apo A-I ratio|• FPG, homeostasis assessment model, insulin, proinsulin, C-peptide|• Tumor necrosis factor-alpha, intracellular adhesion molecule-1|• Fibrinogen|• Urinary albumin excretion|• Waist/hip ratio|• Responder analyses for HbA1c, FPG, TG, HDL C, total cholesterol, non HDL C and LDL C according to pre-specified values|• Proportion of patients reaching pre-specified target levels for HbA1c, FPG, TG, HDL C, non-HDL C and LDL C|• Pharmacokinetics of tesaglitazar|• Safety and tolerability of tesaglitazar by assessment of adverse events, laboratory values, electrocardiogram, pulse, blood pressure, hypoglycemic events, body weight, cardiac evaluation, and physical examination
|
| Locations: |
Research Site, Adelaide, Australia|Research Site, Brisbane, Australia|Research Site, Cairns, Australia|Research Site, Geelong, Australia|Research Site, Melbourne, Australia|Research Site, Perth, Australia|Research Site, Sydney, Australia|Research Site, Tasmania, Australia|Research Site, Angers, France|Research Site, Hyeres, France|Research Site, La Garde, France|Research Site, La Seyne Sur Mer, France|Research Site, Laval, France|Research Site, Le Brusc, France|Research Site, Le Lavandou, France|Research Site, Montrevault, France|Research Site, Paris, France|Research Site, Saint-Cyr, France|Research Site, Six Fours Les Plages, France|Research Site, Tierce, France|Research Site, Toulon, France|Research Site, Ashkelon, Israel|Research Site, Haifa, Israel|Research Site, Holon, Israel|Research Site, Jerusalem, Israel|Research Site, Rishon-Lezion, Israel|Research Site, Tel Aviv, Israel|Research Site, Tel Hashomer, Israel|Research Site, Zefat, Israel|Research Site, Seoul, Korea, Republic of|Research Site, Suwon, Korea, Republic of|Research Site, Bergen, Norway|Research Site, Elverum, Norway|Research Site, Enebakk, Norway|Research Site, Fredrikstad, Norway|Research Site, Gamle Fredrikstad, Norway|Research Site, Hamar, Norway|Research Site, Haugesund, Norway|Research Site, Hurdal, Norway|Research Site, Inderøy, Norway|Research Site, Lena, Norway|Research Site, Levanger, Norway|Research Site, Oslo, Norway|Research Site, Rud, Norway|Research Site, Sedsmokorset, Norway|Research Site, Soerumsand, Norway|Research Site, Stavanger, Norway|Research Site, Manila, Philippines|Research Site, Marikina City, Philippines|Research Site, Pasig City, Philippines|Research Site, Cape Town, South Africa|Research Site, Chatsworth, South Africa|Research Site, Gauteng, South Africa|Research Site, Pretoria, South Africa|Research Site, Alzira (Valencia), Spain|Research Site, Barcelona, Spain|Research Site, Guissona (Lleida), Spain|Research Site, Madrid, Spain|Research Site, San Sebastian de los Reyes ( Madrid), Spain|Research Site, San Vicente de Raspeig (Alicante), Spain|Research Site, Valencia, Spain|Research Site, Dublin, Ireland, United Kingdom|Research Site, Aberdeen, United Kingdom|Research Site, Barnsley, United Kingdom|Research Site, Bath, United Kingdom|Research Site, Belfast, United Kingdom|Research Site, Birmingham, United Kingdom|Research Site, Cardiff, United Kingdom|Research Site, Coventry, United Kingdom|Research Site, Dundee, United Kingdom|Research Site, East Sussex, United Kingdom|Research Site, Edinburgh, United Kingdom|Research Site, Glasgow, United Kingdom|Research Site, Leeds, United Kingdom|Research Site, Liverpool, United Kingdom|Research Site, London, United Kingdom|Research Site, Manchester, United Kingdom|Research Site, Shrewsbury, United Kingdom|Research Site, Surrey, United Kingdom|Research Site, West Midlands, United Kingdom|Research Site, Wiltshire, United Kingdom|Research Site, Wrexham, United Kingdom|Research Site, Hanoi, Vietnam|Research Site, Ho Chi Minh, Vietnam
|
