| Outcome Measures: |
Primary: AEs, assessment AEs by frequency, severity, up to Day14 or 29 | Secondary: Maximum plasma concentration (Cmax) of SSS17, Plasma samples will be collected and Cmax will be assessed., [ up to 48 hours post-dose]|Area under the concentration-time curve (AUC) of plasma concentration of SSS17, Plasma samples will be collected and the AUC from zero to infinity will be assessed., [ up to 48 hours post-dose]|Time-to-Cmax (Tmax) of SSS 17, Plasma samples will be collected and the Tmax will be assessed from the concentration-time curve., [ up to 48 hours post-dose]|Elimination terminal half-life (t1/2) of SSS17, Plasma samples will be collected and the t1/2 will be assessed., [up to 48 hours post-dose]|Total amount of SSS17 excreted in urine over 24 hours (Ae0-24), Urine sample will be collected at pre-specified intervals and Ae0-24 will be assessed., only for one cohort (up to 72 hours post-dose)|Fraction of SSS17 excretion during each collection interval (Fe0-24), Urine sample will be collected at pre-specified intervals and Fe0-24 will be assessed., only for one cohort (up to 72 hours post-dose)|Total amount of SSS17 excreted in urine over 72 hours (Ae0-72), Urine sample will be collected at pre-specified intervals and Ae0-72 will be assessed., only for one cohort (up to 72 hours post-dose)|Fraction of SSS17 excretion during each collection interval (Fe0-72), Urine sample will be collected at pre-specified intervals and Fe0-72 will be assessed., only for one cohort (up to 72 hours post-dose)|Renal clearance (CLR) of SSS17, Urine sample will be collected at pre-specified intervals and CLR will be assessed., only for one cohort (up to 72 hours post-dose)|EPO concentrations, Change of EPO concentrations from baseline following SSS17, up to 168 hours post-dose.|VEGF concentrations, Change of VEGF concentrations from baseline following SSS17, up to 168 hours post-dose.|Change of RTC from baseline, Change of RTC from baseline following SSS17, up to 168 hours post-dose.|Change of RBC from baseline, Change of RBC from baseline following SSS17, up to 168 hours post-dose.|Change of Hgb from baseline, Change of Hgb from baseline following SSS17, up to 168 hours post-dose.|Change of hepcidin from baseline, Change of serum hepcidin concentrations from baseline following SSS17, up to 168 hours post-dose.
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