| Trial ID: | L3078 |
| Source ID: | NCT00696982
|
| Associated Drug: |
Sitagliptin
|
| Title: |
The Effect of Sitagliptin on Hypertension, Arterial Stiffness, Oxidative Stress and Inflammation
|
| Acronym: |
|
| Status: |
UNKNOWN
|
| Study Results: |
NO
|
| Results: |
|
| Conditions: |
Diabetes Mellitus|Arterial Stiffness
|
| Interventions: |
DRUG: sitagliptin|DRUG: glibenclamide
|
| Outcome Measures: |
Primary: arterial stiffness, defined as change in augmentation index measured by means of a non-invasive technique using the commercially available SphygmoCor System, and the results of the 24 hour blood pressure monitoring, 6 months | Secondary: The secondary end results would be oxidative stress parameters, as evaluated by oxidized LDL and Isoprostanes, and markers of inflammatory status, including measurements of pro-inflammatory interleukins and performance of highly sensitive CRP test., 6 months
|
| Sponsor/Collaborators: |
Sponsor: Assaf-Harofeh Medical Center
|
| Gender: |
ALL
|
| Age: |
ADULT, OLDER_ADULT
|
| Phases: |
|
| Enrollment: |
60
|
| Study Type: |
INTERVENTIONAL
|
| Study Designs: |
Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
|
| Start Date: |
2008-06
|
| Completion Date: |
2009-06
|
| Results First Posted: |
|
| Last Update Posted: |
2008-06-13
|
| Locations: |
Department of Internal Medicine A , Research & Development unit Assaf Harofeh Medical Center, Zerifin, affiliated to Sackler School of Medicine, Tel Aviv, Israel, Zrifin, 70300, Israel
|
| URL: |
https://clinicaltrials.gov/show/NCT00696982
|
