| Outcome Measures: |
Primary: Treg response following the induction cure period, expressed as % total CD4 cells, day 5 | Secondary: Fasting plasma concentration of C-peptide, at Day 0, 99, 183, 267, 351, 436|C-peptide AUC response to a mixed meal tolerance test, at baseline, at months 6, 12, 15|IDAA1C score, is a score defined as A1C (percent) + \[4 x insulin dose (units per kilogram per 24 h)\] without unit, at baseline, at months 3, 6, 9, 12, 15|HbA1c, at baseline, at months 3, 6, 9, 12, 15|Treg response after the last administration, day 351, day 436|Treg response during the maintenance period compare to the baseline, Treg response expressed as the % / CD4 will be measured several times, day 15, day 29, day 43, day 99, day 183, day 267
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| Locations: |
Service d'Endocrinologie Pédiatrique, Le Kremlin Bicetre, 94275, France|Service de Pédiatrie - CHU de Nîmes, Nimes, 30029 cedex 9, France|CIC pédiatrique - CHU de Necker, Paris, 75015, France|Service d'endocrinologie pédiatrique - CHU de Necker, Paris, 75015, France|CIC 9202 CHU Rober Débré, Paris, 75019, France|Service d'endocrinologie Diabétologie pédiatrique CHU Robert Débré, Paris, 75019, France
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