Logo 1 Logo 2

Clinical Trial Details

Trial ID: L3118
Source ID: NCT03018665
Associated Drug: Exenatide
Title: A Study of the Effect of Glucagon-like Peptide 1(GLP-1) Receptor Agonist in Combination With Metformin Therapy on Diabetes Remission in Subjects With Newly Diagnosed Type 2 Diabetes Who Are Overweight or Obese
Acronym:
Status: UNKNOWN
Study Results: NO
Results:
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Exenatide|DRUG: BIAsp30|DRUG: Metformin
Outcome Measures: Primary: Rate of Inducing Diabetes Remission, At the end of 12-week treatment|Change of Rate of Maintaining Diabetes Remission, 3,6,12,24,36 months after 12-week treatment|Time of Maintaining Diabetes Remission, up to 36 months after 12-week treatment | Secondary: Change of Blood Pressure, Baseline and 0,3,6,12,24,36 months after 12-week treatment|Change of Heart Rate, baseline and 0,3,6,12,24,36 months after 12-week treatment|Change of Weight, baseline and 0,3,6,12,24,36 months after 12-week treatment|Change of Waistline, baseline and 0,3,6,12,24,36 months after 12-week treatment|Change of Glycosylated Hemoglobin, baseline and 0,3,6,12,24,36 months after 12-week treatment|Change of Pancreatic Beta-cell Function, Pancreatic Beta-cell Function will be evaluated by insulin releasing test. The fasting and 2-hour postprandial plasma glucose concentrations and serum insulin concentrations will be tested., baseline and 0,3,6,12,24,36 months after 12-week treatment|Change of Insulin Resistance Index, baseline and 0,3,6,12,24,36 months after 12-week treatment|The Incidence of Hypoglycemia, During the 12-week treatment|The Incidence of Diabetic Retinopathy, up to 36 months after 12-week treatment|The Incidence of Diabetic Nephropathy, up to 36 months after 12-week treatment
Sponsor/Collaborators: Sponsor: The First Hospital of Jilin University
Gender: ALL
Age: ADULT, OLDER_ADULT
Phases: PHASE4
Enrollment: 200
Study Type: INTERVENTIONAL
Study Designs: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Start Date: 2017-02
Completion Date:
Results First Posted:
Last Update Posted: 2017-01-12
Locations: First Hospital of Jilin University, Changchun, Jilin, 130021, China
URL: https://clinicaltrials.gov/show/NCT03018665