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Clinical Trial Details

Trial ID: L3133
Source ID: NCT06277466
Associated Drug: Fresh Normal Pancreatic Tissues Or Adjacent Tissues Of Pancreatic Cancer Were Collected From Controls And T2dm Patients Without Hypoglycemic Drugs
Title: Effect of Mutations in T2DM Susceptibility Genes on the Expression of Susceptibility Genes in Patients With T2DM and Controls
Acronym:
Status: RECRUITING
Study Results: NO
Results:
Conditions: Type 2 Diabetes Mellitus|Gene Polymorphisms|Genetic Mutations|Susceptibility, Genetic
Interventions: DRUG: Fresh normal pancreatic tissues or adjacent tissues of pancreatic cancer were collected from controls and T2DM patients without hypoglycemic drugs|DRUG: Fresh blood samples were collected from healthy subjects and T2DM patients without hypoglycemic drugs
Outcome Measures: Primary: Detection of T2DM susceptibility gene expression in newly diagnosed T2DM patients, To detect the expression levels of susceptible genes in the plasma and the pancreatic tissues of newly diagnosed T2DM patients and compared with those in healthy subjects., 1 month after fresh sample collection|Detection of T2DM susceptibility gene expression in controls, To detect the expression levels of susceptible genes in the plasma and the pancreatic tissues of controls and compared with those in newly diagnosed T2DM patients., 1 month after fresh sample collection|Correlation between T2DM susceptibility gene expression and clinicopathological features, Incidence of clinical pancreatic diseases under expression differences in T2DM susceptibility genes, 6 months after obtaining the clinicopathological results | Secondary: Baseline BMI of newly diagnosed with T2DM patients with different genotypes, Baseline BMI of newly diagnosed with T2DM patients, 1 month of completion for individual screening|Baseline waist hip ratio (WHR) of newly diagnosed with T2DM patients with different genotypes, Baseline WHR of newly diagnosed with T2DM patients, 1 month of completion for individual screening|Baseline fasting plasma glucose (FPG) of newly diagnosed with T2DM patients with different genotypes, Baseline FPG of newly diagnosed with T2DM patients, 1 month of completion for individual screening|Baseline HbA1c of newly diagnosed with T2DM patients with different genotypes, Baseline HbA1c of newly diagnosed with T2DM patients, 1 month of completion for individual screening|Baseline TC of newly diagnosed with T2DM patients with different genotypes, Baseline TC of newly diagnosed with T2DM patients, 1 month of completion for individual screening|Baseline TG of newly diagnosed with T2DM patients with different genotypes, Baseline TG of newly diagnosed with T2DM patients, 1 month of completion for individual screening|Baseline HDL-C of newly diagnosed with T2DM patients with different genotypes, Baseline HDL-C of newly diagnosed with T2DM patients, 1 month of completion for individual screening|Baseline LDL-C of newly diagnosed with T2DM patients with different genotypes, Baseline LDL-C of newly diagnosed with T2DM patients, 1 month of completion for individual screening|Baseline BMI of controls with different genotypes, Baseline BMI of controls, 1 month of completion for individual screening|Baseline WHR of controls with different genotypes, Baseline WHR of controls, 1 month of completion for individual screening|Baseline FPG of controls with different genotypes, Baseline FPG of controls, 1 month of completion for individual screening|Baseline HbA1c of controls with different genotypes, Baseline HbA1c of controls, 1 month of completion for individual screening|Baseline TC of controls with different genotypes, Baseline TC of controls, 1 month of completion for individual screening|Baseline TG of controls with different genotypes, Baseline TG of controls, 1 month of completion for individual screening|Baseline HDL-C of controls with different genotypes, Baseline HDL-C of controls, 1 month of completion for individual screening|Baseline LDL-C of controls with different genotypes, Baseline LDL-C of controls, 1 month of completion for individual screening
Sponsor/Collaborators: Sponsor: The Affiliated Hospital of Xuzhou Medical University
Gender: ALL
Age: ADULT, OLDER_ADULT
Phases:
Enrollment: 300
Study Type: INTERVENTIONAL
Study Designs: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Start Date: 2024-01-01
Completion Date: 2028-01-31
Results First Posted:
Last Update Posted: 2024-02-28
Locations: China, Jiangsu, Department of Endocrinology, Xuzhou, 221006, China
URL: https://clinicaltrials.gov/show/NCT06277466