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Clinical Trial Details

Trial ID: L3331
Source ID: NCT01243424
Associated Drug: Linagliptin
Title: CAROLINA: Cardiovascular Outcome Study of Linagliptin Versus Glimepiride in Patients With Type 2 Diabetes
Acronym:
Status: COMPLETED
Study Results: YES
Results: https://ClinicalTrials.gov/show/NCT01243424/results
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: linagliptin|DRUG: glimepiride|DRUG: linagliptin placebo|DRUG: glimepiride placebo
Outcome Measures: Primary: The First 3-point Major Adverse Cardiovascular Events (3P-MACE), The first occurrence of any of the following Clinical Event Committee (CEC) confirmed adjudicated components of the primary composite endpoint: CV death (including fatal stroke and fatal myocardial infarction (MI)), non-fatal MI (excluding silent MI), or nonfatal stroke is presented., From randomization until individual day of trial completion, up to 432 weeks | Secondary: The First 4-point (4P)- MACE, The first key secondary endpoint was time to first occurrence of any of the following adjudicated components of the composite endpoint: CV death (including fatal stroke and fatal MI), non-fatal stroke, non-fatal MI (excluding silent MI), or hospitalisation for unstable angina pectoris., From randomization until individual day of trial completion, up to 432 weeks|Percentage of Participants Taking Trial Medication at Trial End, Maintained Glycaemic Control (HbA1c ≤7.0%) Without Need for Rescue Medication, Without >2% Weight Gain, and Without Moderate/Severe Hypoglycaemic Episodes During Maintenance Phase, The second key secondary endpoint was a composite endpoint of treatment sustainability, defined as the percentage of patients taking trial medication at trial end, maintained glycaemic control (HbA1c ≤7.0%) without need for rescue medication, without \>2% weight gain, and without moderate/severe hypoglycaemic episodes during maintenance phase., From Visit 6 (Week 16) to Final visit (Week 432) (Maintenance Phase)|Percentage of Participants Who Were on Trial Medication at Trial End, Maintained Glycaemic Control (HbA1c ≤7.0%) Without Need for Rescue Medication, and Without >2% Weight Gain During Maintenance Phase, The third key secondary endpoint was a composite endpoint of treatment sustainability, defined as percentage of patients who were on trial medication at trial end, maintained glycaemic control (HbA1c ≤7.0%) without need for rescue medication, and without \>2% weight gain during maintenance phase., From Visit 6 (Week 16) to Final visit (Week 432) (Maintenance Phase)|Percentage of Participants With the Occurrence of at Least One Event of 3P-MACE, Percentage of participants occurrence of at least one of the following adjudicated components of CV death (including fatal stroke and fatal MI), non-fatal MI (excluding silent MI) and non-fatal stroke is presented as secondary CV endpoint., From randomization until individual day of trial completion, up to 432 weeks|Percentage of Participants With the Occurrence of at Least One Event of 4P -MACE, Percentage of participants occurrence of at least one of the following adjudicated components of CV death (including fatal stroke and fatal MI), non-fatal MI (excluding silent MI), non-fatal stroke, and hospitalisation for unstable angina pectoris is presented as secondary CV endpoint., From randomization until individual day of trial completion, up to 432 weeks|Percentage of Participants With Occurrence of Any of the Components of the Composite Endpoint of All Adjudication-confirmed Events, Percentage of participants with occurrence of any of the following components of the composite endpoint of all adjudication-confirmed events of: * CV death (including fatal stroke and fatal MI) * non-fatal MI * non-fatal stroke * hospitalisation for unstable angina pectoris * TIA * hospitalisation for heart failure * hospitalisation for coronary revascularisation procedures (CABG, PCI), From start of the treatment until 7 days after the end of treatment, up to 433 weeks|Time to First Occurrence of Any of the Components of the Composite Endpoint of All Adjudication-confirmed Events, Time to first occurrence of any of the following components of the composite endpoint of all adjudication-confirmed events of: * CV death (including fatal stroke and fatal MI) * non-fatal MI * non-fatal stroke * hospitalisation for unstable angina pectoris * Transient ischaemic attack (TIA) * hospitalisation for heart failure * hospitalisation for coronary revascularisation procedures (CABG, PCI), From start of the treatment until 7 days after the end of treatment, up to 433 weeks|Change From Baseline to Final Visit in Hemoglobin A1c (HbA1c), Change from baseline to final visit in HbA1c is presented as secondary diabetes-related endpoint. Least square mean is adjusted mean. The Final Visit value referred to the last value obtained on-treatment., Baseline and week 432|Change From Baseline to Final Visit in Fasting Plasma Glucose (FPG), Change from baseline to final visit in fasting plasma glucose (FPG) is presented as secondary diabetes-related endpoint. Least square mean is adjusted mean. The Final Visit value referred to the last value obtained on-treatment., Baseline and week 432|Change From Baseline to Final Visit Fasting Total Cholesterol, Low-density Lipoprotein (LDL) Cholesterol and High-density Lipoprotein (HDL) Cholesterol, Change from baseline to final visit in total cholesterol, low-density lipoprotein (LDL) cholesterol and high-density lipoprotein (HDL) cholesterol is presented as secondary diabetes-related endpoint. Least square mean is adjusted mean. The Final Visit value referred to the last value obtained on-treatment., Baseline and week 432|Change From Baseline to Final Visit in Triglycerides, Change from baseline to final visit in triglycerides is presented as secondary diabetes-related endpoint. Least square mean is adjusted mean. The Final Visit value referred to the last value obtained on-treatment., Baseline and week 432|Change From Baseline to Final Visit in Creatinine, Change from baseline to final visit in creatinine is presented as secondary diabetes-related endpoint. Least square mean is adjusted mean. The Final Visit value referred to the last value obtained on-treatment., Baseline and week 432|Change From Baseline to Final Visit in Estimated Glomerular Filtration Rate (eGFR), Change from baseline to final visit in eGFR is presented as secondary diabetes-related endpoint. Least square mean is adjusted mean. The Final Visit value referred to the last value obtained on-treatment., Baseline and week 432|Change From Baseline to Final Visit in Urine Albumin Creatinine Ratio (UACR), Change from baseline to final visit in UACR is presented as secondary diabetes-related endpoint. Least square mean is adjusted geometric mean (gMean) ratio. The Final Visit value referred to the last value obtained on-treatment., Baseline and week 432|Percentage of Participants With Transition in Albuminuria Classes, Percentage of patients with transition in albuminuria classes is presented as secondary endpoint. Data for last value on treatment (LVOT) to baseline (base) is presented., Baseline and week 432|Change From Baseline of Insulin Secretion Rate (ISR) at Fixed Glucose Concentration at 208 Weeks, The endpoint change from baseline of ISR at fixed glucose concentration at 208 weeks as derived from a 3-hour meal tolerance test is Beta-cell function sub-study endpoint., Baseline and week 208|Percentage of Participants With Occurrence of Accelerated Cognitive Decline at End of Follow-up, Occurrence of accelerated cognitive decline based on regression based index (RBI) score at end of follow-up (a dichotomous outcome measure; presence or absence of accelerated cognitive decline) is Cognition sub-study endpoint., 433 weeks|Continuous Glucose Monitoring (CGM) Sub-study: Change From Baseline in the Inter-quartile Range of Diurnal Glucose Variability (Milligrams/ Deciliter) to End of Study, Baseline data for the continuous glucose monitoring sub-study was collected and analyzed. However, the participant number was far less than original planned. The study was stopped early around week 64 (V9) due to recruitment issues and data were not pre-specified to be analyzed and reported at week 64 time point as target was with an estimated time point of 432 weeks for primary or secondary end points. Thus this endpoint was not analysed and only the baseline data collected were analysed and the results are reported in this CGM substudy endpoint., Baseline|CGM Sub-study : Change From Baseline in the Inter-quartile Range of Diurnal Glucose Variability (Millimoles/ Litre) to End of Study, Baseline data for the continuous glucose monitoring sub-study was collected and analyzed. However, the participant number was far less than original planned. The study was stopped early around week 64 (V9) due to recruitment issues and data were not pre-specified to be analyzed and reported at week 64 time point as target was with an estimated time point of 432 weeks for primary or secondary end points. Thus this endpoint was not analysed and only the baseline data collected were analysed and the results are reported in this CGM substudy endpoint., Baseline
Sponsor/Collaborators: Sponsor: Boehringer Ingelheim | Collaborators: Eli Lilly and Company
Gender: ALL
Age: ADULT, OLDER_ADULT
Phases: PHASE3
Enrollment: 6103
Study Type: INTERVENTIONAL
Study Designs: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Start Date: 2010-11-11
Completion Date: 2018-08-21
Results First Posted: 2020-01-07
Last Update Posted: 2020-01-07
Locations: North Alabama Research Center, LLC, Athens, Alabama, 35611, United States|Alabama Internal Medicine, PC, Birmingham, Alabama, 35235, United States|Cahaba Research, Inc., Birmingham, Alabama, 35242, United States|Internal Medicine Center, LLC, Mobile, Alabama, 36608, United States|Diagnostic and Medical Clinic, Mobile, Alabama, 36695, United States|Extended Arm Physicians, Inc., Montgomery, Alabama, 36106, United States|Office of Dr. Terence T. Hart MD, Tuscumbia, Alabama, 35674, United States|Advanced Clinical Research, Pell City, Alaska, 35128, United States|Clinical Research Advantage, Inc./Rita B. Chuang, MD, LLC, Mesa, Arizona, 85203, United States|Clinical Research Advantage, Inc./Rita B. Chuang, MD, LLC, Mesa, Arizona, 85213, United States|Genova Clinical Research, Tucson, Arizona, 85704, United States|Quality of Life Medical & Research Center, Tucson, Arizona, 85712, United States|Northeast Arkansas Baptist Clinic, Jonesboro, Arkansas, 72404, United States|Medical Investigations, Inc, Little Rock, Arkansas, 72205, United States|Aureus Research, Inc, Little Rock, Arkansas, 72211, United States|Desert Oasis Healthcare, Bermuda Dunes, California, 92203, United States|Edinger Medical Group and Research Center, Fountain Valley, California, 92708, United States|Clinical Trials of St. Jude Heritage Med. Group, Fullerton, California, 92835, United States|Long Beach Center for Clinical Research, Long Beach, California, 90807, United States|Office of Dr. Richard S. Cherlin, Los Gatos, California, 95032, United States|Providence Clinical Research, North Hollywood, California, 91606, United States|Chaparral Medical Group, Inc, Pomona, California, 91767, United States|ARI Clinical Trials, Inc, Redondo Beach, California, 90277, United States|San Diego Sports Medicine and Family Health Center, San Diego, California, 92120, United States|West Coast Research, LLC, San Ramon, California, 94582, United States|University of California Los Angeles, Sylmar, California, 91342, United States|Metabolic Institute of America, Tarzana, California, 91356, United States|Matrix Research Institute, Tustin, California, 92780, United States|Orange County Research Center, Tustin, California, 92780, United States|Westlake Medical Research, Westlake Village, California, 91361, United States|Clinical Research Advantage, Inc./Rita B. Chuang, MD, LLC, Colorado Springs, Colorado, 80909, United States|Clinical Research Advantage, Inc./Rita B. Chuang, MD, LLC, Colorado Springs, Colorado, 80920, United States|East Coast Medical Associates, Boca Raton, Florida, 33433, United States|Todd Kazdan, DO Family Practice, Davie, Florida, 33314, United States|Century Clinical Research, Inc, Daytona Beach, Florida, 32117, United States|Doral Research Center, Doral, Florida, 33172, United States|Riverside Clinical Research, Edgewater, Florida, 32132, United States|Alan Graff, MD, PA, Fort Lauderdale, Florida, 33309, United States|M & O Clinical Research, LLC, Fort Lauderdale, Florida, 33316, United States|Eastern Research, Hialeah, Florida, 33013, United States|Research in Miami Inc, Hialeah, Florida, 33013, United States|Jacksonville Impotence Treatment Center, Jacksonville, Florida, 32223, United States|East Coast Institute for Research, LLC, Jacksonville, Florida, 32258, United States|Care Partners Clinical Research LLC, Jacksonville, Florida, 32277, United States|Precision Clinical Research, LLC, Lauderdale Lakes, Florida, 33319, United States|Veritas Research Corporation, Miami, Florida, 33126, United States|APF Research, LLC, Miami, Florida, 33134, United States|Swiss Medical Research, Miami, Florida, 33135, United States|University of Miami, Miami, Florida, 33136, United States|South Miami Clinical Research, Miami, Florida, 33143, United States|Well Pharma Medical Research, Miami, Florida, 33143, United States|Advanced Pharma CR, LLC, Miami, Florida, 33147, United States|AppleMed Research Group, LLC, Miami, Florida, 33155, United States|Kendall South Medical Center, Inc, Miami, Florida, 33185, United States|Suncoast Clinical Research, Inc., New Port Richey, Florida, 34652, United States|Advanced Research Institute, Inc, New Port Richey, Florida, 34653, United States|Sunshine Research Center, Opa-locka, Florida, 33054, United States|Diabetes and Endocrine Center of Orlando, Orlando, Florida, 32803, United States|Suncoast Clinical Research, Palm Harbor, Florida, 34684, United States|Misal Khan, MD FRCS, ED, PA, Panama City, Florida, 32401, United States|Iconic Clinical Trials, Pembroke Pines, Florida, 33024, United States|Gulf Region Clinical Research Institute, Pensacola, Florida, 32514, United States|St. John's Center for Clinical Research, Ponte Vedra Beach, Florida, 32081, United States|Metabolic Research Institute, West Palm Beach, Florida, 33401, United States|PMI Health Research Group, Atlanta, Georgia, 30312, United States|Atlanta Diabetes Associates, Atlanta, Georgia, 30318, United States|Albert F. Johary MD, PC, Dunwoody, Georgia, 30338, United States|Georgia Clinical Research, LLC, Snellville, Georgia, 30078, United States|Hayden Lake Family Physicians, Hayden Lake, Idaho, 83835, United States|Boise Kidney and Hypertension Institute, Meridian, Idaho, 83642, United States|Suburban Clinical Research, Bolingbrook, Illinois, 60490, United States|Cedar-Crosse Research Center, Chicago, Illinois, 60607, United States|John H. Stroger Jr. Hospital of Cook Country, Chicago, Illinois, 60612, United States|Apex Medical Research, Chicago, Illinois, 60616, United States|Pharmakon Inc, Evergreen Park, Illinois, 60805, United States|American Health Network, Avon, Indiana, 46123, United States|Investigators Research Group, LLC, Brownsburg, Indiana, 46112, United States|American Health Network of Indiana, LLC, Franklin, Indiana, 46131, United States|Mapleton Medical Center, Indianapolis, Indiana, 46205, United States|American Health Network, LLC, Indianapolis, Indiana, 46254, United States|McKinley Research, LLC, Mishawaka, Indiana, 46545, United States|American Health Network of Indiana, LLC, Muncie, Indiana, 47304, United States|MCM Clinical Research, LLC, Florence, Kentucky, 41042, United States|Kentucky Diabetes Endocrinology Center, Lexington, Kentucky, 40503, United States|Four Rivers Clinical Research, Inc, Paducah, Kentucky, 42003, United States|Crescent City Clinical Research, Metairie, Louisiana, 70006, United States|Acadia Clinical Research, LLC, Bangor, Maine, 04401, United States|Office of Dr. Stephen R. Smith, MD, Baltimore, Maryland, 21234, United States|Endocrine and Metabolic Consultants, Rockville, Maryland, 20852, United States|Tristan Medical Enterprises, PC dba Regeneris, North Attleboro, Massachusetts, 02760, United States|ClinSite, LLC, Canton, Michigan, 48187, United States|Apex Medical Research, AMR Inc, Flint, Michigan, 48504, United States|Westside Family Medical Center, PC, Kalamazoo, Michigan, 49009, United States|Tri City Medical Centers, PC, Livonia, Michigan, 48152, United States|KMED Research, Saint Clair Shores, Michigan, 48081, United States|Tri-County Research, Inc, Sterling Heights, Michigan, 48310, United States|Medical Research Associates, Traverse City, Michigan, 49684, United States|Oakland Medical Research Center, Troy, Michigan, 48085, United States|Park Nicollet Institute, Minneapolis, Minnesota, 55416, United States|The Center for Clinical Trials, Inc., Biloxi, Mississippi, 39531, United States|Mercy Health Research, Saint Louis, Missouri, 63141, United States|Quality Clinical Research, Omaha, Nebraska, 68114, United States|Clinical Research Advantage, Inc./Rita B. Chuang, MD, LLC, Henderson, Nevada, 89052, United States|Clinical Research of South Nevada, Las Vegas, Nevada, 89121, United States|Palm Medical Research Center, Las Vegas, Nevada, 89148, United States|Atco Medical Associates, PC, Atco, New Jersey, 08004, United States|Summit Medical Group, Clifton, New Jersey, 07012, United States|USMA Clinical Research, Elizabeth, New Jersey, 07201, United States|Central Jersey Medical Research, Elizabeth, New Jersey, 07202, United States|Albany Medical Center / Albany Medical College, Albany, New York, 12206, United States|Endocrine Associates of Long Island, PC, Smithtown, New York, 11787, United States|Southgate Medical Group/ Southgate Medical Park, West Seneca, New York, 14224, United States|OnSite Clinical Solutions, LLC, Asheville, North Carolina, 28801, United States|Kernodle Clinic West, Burlington, North Carolina, 27215, United States|The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27517, United States|Internal Medicine Research, Charlotte, North Carolina, 28204, United States|Gaffney Health Services, Charlotte, North Carolina, 28205, United States|Durham Internal Medicine Associates, Durham, North Carolina, 27704, United States|Sentara Family Medicine, Elizabeth City, North Carolina, 27909, United States|PMG Research of Raleigh, LLC, Raleigh, North Carolina, 27609, United States|Carolina Research Center, Inc, Shelby, North Carolina, 28150, United States|Piedmont Healthcare, Statesville, North Carolina, 28625, United States|PMG Research of Wilmington, LLC, Wilmington, North Carolina, 28401, United States|Community Health Care of Manchester, Akron, Ohio, 44319, United States|Community Medical Associates, LLC, Austintown, Ohio, 44515, United States|Harrison Community Research Center, Cadiz, Ohio, 43907, United States|Medical Frontiers, LLC, Carlisle, Ohio, 45005, United States|Genoa Medical Center, Genoa, Ohio, 43430, United States|Office of Dr. Craig S. Thompson, MD, LLC, Marion, Ohio, 43302, United States|RAS Health Limited, Marion, Ohio, 43302, United States|Advanced Medical Research, LLC, Maumee, Ohio, 43537, United States|Pharmacotherapy Research Associates, Inc, Zanesville, Ohio, 43701, United States|Infinity Research Group, LLC, Oklahoma City, Oklahoma, 73103, United States|Castlerock Clinical Research Consultants, LLC, Tulsa, Oklahoma, 74136, United States|Oregon Medical Group, Eugene, Oregon, 97401, United States|Harleysville Medical Associates, Harleysville, Pennsylvania, 19438, United States|Detweiler Family Medicine & Associates, PC, Lansdale, Pennsylvania, 19446, United States|Temple University School of Medicine, Philadelphia, Pennsylvania, 19140, United States|Warminster Medical Associates, PC, Warminster, Pennsylvania, 18974, United States|New England Center for Clinical Research, Inc, Cranston, Rhode Island, 02920, United States|Hartwell Research Group, LLC, Anderson, South Carolina, 29621, United States|Paris View Family Practice, Greenville, South Carolina, 29601, United States|Mountain View Clinical Research, Greer, South Carolina, 29651, United States|South Carolina Nephrology and Hypertension Center, Inc, Orangeburg, South Carolina, 29118, United States|Carolina Diabetes & Kidney Center, Sumter, South Carolina, 29150, United States|PMG Research of Bristol, Bristol, Tennessee, 37620, United States|University Diabetes and Endocrine Consultants, Chattanooga, Tennessee, 37411, United States|University of Tennessee, Memphis, Tennessee, 38163, United States|Trinity Clinical Research, LLC, Tullahoma, Tennessee, 37388, United States|KRK Medical Research, Arlington, Texas, 76012, United States|Austin Center for Clinical Research, Austin, Texas, 78758, United States|Punzi Medical Center, Carrollton, Texas, 75006, United States|Dallas Diabetes and Endocrine Center, Dallas, Texas, 75230, United States|Baylor Endocrine Center, Dallas, Texas, 75246, United States|University of Texas Southwestern Medical Center, Dallas, Texas, 75390-8858, United States|Jacon Medical Research Associates, LLC, Houston, Texas, 77030, United States|JVC Family Medicine, Houston, Texas, 77040, United States|Clinical Trial Network, Houston, Texas, 77074, United States|Endocrine and Psychiastry Center, Houston, Texas, 77095, United States|Pioneer Research Solutions, Inc., Houston, Texas, 77099, United States|Midland Clinical Research Center, Midland, Texas, 79707, United States|Hill Country Medical Associates, New Braunfels, Texas, 78130, United States|Naidu Clinic, Odessa, Texas, 79761, United States|The Methodist Hospital d/b/a HMRI CCAT at Pearland, Pearland, Texas, 77584, United States|Village Health Partners, Plano, Texas, 75024, United States|Sun Research Institute, San Antonio, Texas, 78215, United States|Northeast Clinical Research of San Antonio, LLC, Schertz, Texas, 78154, United States|Kenneth Otah and Associates, Sugar Land, Texas, 77478, United States|PHS Clinical Trials, Midvale, Utah, 84047, United States|Highland Clinical Research, Salt Lake City, Utah, 84124, United States|Burke Internal Medicine and Research, Burke, Virginia, 22015, United States|Ettrick Health Center, Ettrick, Virginia, 23803, United States|Manassas Clinical Research Center, Manassas, Virginia, 20110, United States|Clinical Research Partners, LLC, Richmond, Virginia, 23220, United States|Richmond Family Practice, Richmond, Virginia, 23220, United States|Larry D Stonesifer, MD Inc., PS, Federal Way, Washington, 98003, United States|Premier Clinical Research, Spokane, Washington, 99204, United States|Instituto de Investigaciones Clínicas de Bahía Blanca, Bahía Blanca, B8000FTD, Argentina|CIPREC, Caba, C1119ACN, Argentina|CENUDIAB, Caba, C1440AAD, Argentina|Instituto Médico Especializado, Capital Federal, C1405BCH, Argentina|Consultorios Asociados de Endocrinología e Invest Clínica, Capital Federal, C1425AGC, Argentina|IPAC - Clínica Privada Caraffa SRL, Cordoba, X5008KKF, Argentina|Instituto Cardiovascular de Corrientes Juana Francisca Cabra, Corrientes, W3400AMZ, Argentina|Ilaim-Ceom, Córdoba, X5000BNB, Argentina|Hospital Italiano de La Plata, La Plata, B1900AWT, Argentina|CIPADI, Mendoza, M5500EVJ, Argentina|Instituto de Investigaciones Clinicas de Rosario, Rosario, S2000CVD, Argentina|Instituto de Hematología y Medicina Clínica Dr. Rubén Davoli, Rosario, S2000CXP, Argentina|Hospital San Bernardo, Salta, A4406CLA, Argentina|Investigaciones Clinicas Tucuman, San Miguel de Tucumán, T4000ICL, Argentina|Instituto de Investigaciones Biomédicas, Santa Fe, S3000FNF, Argentina|Centro de Investigaciones Clínicas del Litoral, Santa Fe, S3000SWO, Argentina|Royal Brisbane & Women's Hospital-Endocrinology, Herston, Queensland, 4029, Australia|Logan Hospital, Meadowbrook, Queensland, 4131, Australia|Royal Adelaide Hospital, Adelaide, South Australia, 5000, Australia|Eastern Clinical Research Unit, East Ringwood, Victoria, 3135, Australia|Royal Melbourne Hospital, Parkville, Victoria, 3050, Australia|Blankenberge - PRAC Vileyn, Geert, Blankenberge, 8370, Belgium|Bonheiden - HOSP Imelda, Bonheiden, 2820, Belgium|De Pinte - PRAC Hollanders, Geert, De Pinte, 9840, Belgium|Retie - PRAC De Vos, Axel, Dessel, 2480, Belgium|Deurne - PRAC Heyvaert, Frank, Deurne, 2100, Belgium|Deurne - PRAC Verelst, Joost, Deurne, 2100, Belgium|Genk - PRAC Vernijns, J., Genk, 3600, Belgium|Gozée - PRAC De Meulemeester, Marc, Gozée, 6534, Belgium|Hasselt - PRAC Vantroyen, Daniel, Hasselt, 3500, Belgium|Herent - PRAC Denolf, Bart, Herent, 3020, Belgium|Linkebeek - PRAC Maury, Olivier, Linkebeek, 1630, Belgium|Moorsel - PRAC Van Mulders, N., Moorsel, 9310, Belgium|Natoye - PRAC Balthazar, Y., Natoye, 5360, Belgium|Tremelo - PRAC Vermeersch, Lode, Tremelo, 3210, Belgium|Hospital Universitário João de Barros Barreto, Belém, 66073-000, Brazil|Universidade Federal do Paraná, Curitiba, 80060-900, Brazil|Hospital Geral de Goiânia Alberto Rassi, Goiânia, 74043-110, Brazil|Centro de Pesquisas Clínicas Ltda, Higienópolis, 01244-030, Brazil|Centro de Estudos em Diabetes e Hipertensão, Joaquim Távora, 60115-282, Brazil|Irmandade Santa Casa de Misericordia de Porto Alegre, Porto Alegre, 90020-090, Brazil|Centro de Pesquisas em Diabetes, Porto Alegre, 90035-170, Brazil|Instituto Estadual de Diabetes e Endocrinologia, Río de Janeiro, 20211-340, Brazil|Irmandade da Santa Casa de Misericórdia de São Paulo - IPEC - Instituto de Pesquisa Clínica, Santa Cecília, 01221-020, Brazil|Instituto de Molestias Cardiovasculares - IMC, São José do Rio Preto, 15015-210, Brazil|Hospital das Clinicas da FMUSP, São Paulo, 05403-900, Brazil|Hospital do Rim e Hipertensão - UNIFESP, Vila Clementino, 04025-011, Brazil|Univ.Multiprofile Hospital "Dr. Georgy Stranski" EAD, Pleven, Pleven, 5800, Bulgaria|Multiprofile Hospital for Active Treatment, Sofia, 1431, Bulgaria|Multiprofile Hospital for Active Treatment "Zaritza Johanna", Sofia, 1527, Bulgaria|Military Medical Academy, Clin. Endocrinology & Metab. Dis., Sofia, 1606, Bulgaria|MHAT Prof Stoyan Kirkovich AD, Stara Zagora, 6000, Bulgaria|IUCPQ (Laval University), Quebec, Migration Data, G1V 4G5, Canada|First Line Medical Services Ltd., St. John's, Newfoundland and Labrador, A1E 2C2, Canada|Topsail Road Medical Clinic, St. John's, Newfoundland and Labrador, A1E 2E2, Canada|Cambridge Cardiac Care Inc., Cambridge, Ontario, N1R 6V6, Canada|Hamilton Medical Research Group, Hamilton, Ontario, L8M 1K7, Canada|SKDS Research Incorporated, Newmarket, Ontario, L3Y 5G8, Canada|Wilderman Medical Clinic, Thornhill, Ontario, L4J 1W3, Canada|St. Michael's Hospital, Toronto, Ontario, M5C 2T2, Canada|Albion Finch Medical Centre, Toronto, Ontario, M9V 4B4, Canada|Kings County Medical Centre, Montague, Prince Edward Island, C0A 1R0, Canada|Dynamik Research, Pointe Claire, Quebec, H9R 3J1, Canada|Consulta Privada Maria Loreto Aguirre Coveña, Providencia, 7500010, Chile|Hospital de Servicios Médicos Godoy Ltda, Providencia, Chile|Centro Medico Antulawen, Temuco, Chile|Hospital Naval Almirante Nef, Viña del Mar, Chile|BioMelab, Barranquilla, Colombia|Centro Cientifico Asistencial Jose Luis Accini, Barranquilla, Colombia|Fundacion del Caribe de Investigacion Biomedica, Barranquilla, Colombia|Endocare Research Institute, Bogota, Colombia|Dexa Diabetes Servicios Médicos Ltda, Bogotá, Colombia|UNIENDO Unidad Integral de Endocrinologia, Bogotá, Colombia|Centro cardiovascular Aristides, Cartagena, Colombia|centro de Diagnostico Cardiologico para la Investigacion Bio, Cartagena, Colombia|Fundacion Cardiovascular de Colombia, El Bosque, Colombia|Fundación Oftalmologica de Santander, El Bosque, Colombia|Fundación Centro de Investigaciones Biomédicas Riescard, Tolima, Colombia|Internal & Diabetology Ambulance, Jablonec nad Nisou, Jablonec nad Nisou, 466 01, Czechia|Diabetology & Internal Ambulance, Olomouc-Lazce, 779 00, Czechia|Internal & Diabetology Ambulance Dr. Vrkoc, Ostrava, Ostrava, 702 00, Czechia|Cardiology ambulance, Plzen, Plzen, 301 00, Czechia|ResTrial s.r.o., Praha 8, 181 00, Czechia|Diebetology internal Ambulance, Praha, 101 00, Czechia|Internal & Diabetology Ambulance, Prostejov, Prostejov, 796 01, Czechia|Hospital Strakonice, Internal Department, Strakonice, 386 29, Czechia|Diabetesklinikka, Mehiläinen Töölö, Helsinki, 00260, Finland|Lääkärikeskus Ite, Joensuu, 80100, Finland|Lääkärikeskus Aava Kerava, Kerava, 04200, Finland|Kokkolan Lääkärikeskus, Kokkola, 67100, Finland|IteLasaretti, Kuopio, FI-70100, Finland|Terveystalo Oulu, Diapolis, Oulu, FI-90100, Finland|TYKS, Turku, FI-20520, Finland|CAB Hell M, MG, Behren Les Forbach, Behren Les Forbach, 57460, France|HOP Haut Levèque, Diabéto, Pessac, Bordeaux, 33075, France|CAB Lemarie B, MG, Bourg des Cptes, Bourg des Comptes, 35890, France|CAB Cadinot Dr D, Broglie, Broglie, 27270, France|CAB Breton Dr Nicolas, Béziers, 34500, France|CAB Ferrier R, MG, Cannes, Cannes, 06400, France|CAB Jordan E, MG, Carbonne, Carbonne, 31390, France|CAB Merlin P, MG Castets, Castets, 40260, France|CAB Fonteny R, MG, Chartres, Chartres, 28000, France|CAB Fournier P, MG, Chartres, Chartres, 28000, France|CAB Martocq G, MG, Cournonterral, Cournonterral, 34660, France|HOP, Fort de France, Fort de France, Fort De France, 97261, France|CAB Le Mouel S, MG, Hinx, Hinx, 40180, France|CAB Pholsena, MG, La Réunion, La Reunion, 97410, France|CAB Bismuth M, Labarthe sur Leze, 31860, France|CAB Zimmermann D, Louvigne De Bie, 35680, France|CAB Mainetti P, MG, Maintenon, Maintenon, 28130, France|CAB Barucq F, MG, Orthez, Orthez, 64300, France|CAB Mostephai M, Orthez, 64300, France|CAB Cassagnes JL, MG, Palau Del Vidre, Palau Del Vidre, 66690, France|CAB Mercey Y, MG, St Genies des Fontaines, Saint Genies Des Fontaines, 66740, France|Hop St Dié des Vosges, Diabéto, St Dié des Vosges, St Dié des Vosges Cedex, 88187, France|CAB Bonneau D, MG, Thouars, Thouars, 79100, France|CAB Morel H, MG, Tilly sur Seulles, Tilly sur Seulles, 14250, France|Unimed Ajara LLC, Private Practice, Batumi, 6004, Georgia|Central Hospital LTD 'Gormedi', Gori, Gori, 1400, Georgia|L&J Clinic, Kutaisi, Kutaisi, 4600, Georgia|EC Cardiology Clinic,Tbilisi, Tbilisi, 0144, Georgia|National Center for Diabetes Research Ltd., Tbilisi, Tbilisi, 0159, Georgia|National Institute of Endocrinology, Tbilisi, Tbilisi, 0159, Georgia|Zhordania Institute of Human Reproduction, Tbilisi, Tbilisi, 0159, Georgia|Medical Centre Medelite Ltd., Tbilisi, Tbilisi, 0177, Georgia|Chemotherapy & Immunotherapy Clinic 'Medulla', Tbilisi, Tbilisi, 0186, Georgia|JSC 'Curatio', Zugdidi, 2100, Georgia|Universitätsklinikum Aachen, AöR, Aachen, 52074, Germany|Studienzentrum Klausmann, Aschaffenburg, 63739, Germany|Gemeinschaftspraxis, Asslar, Asslar, 35614, Germany|Diabetes Schwerpunktpraxis, Bad Nauheim, 61231, Germany|Praxis Dr. Naumburger, Berlin, Berlin, 10409, Germany|emovis GmbH, Berlin, 10629, Germany|Praxis Dr. Rieker, Berlin, Berlin, 10789, Germany|IFG Institut für Gesundheitsförderung GmbH, Berlin, 12621, Germany|MVZ DaVita Dormagen GmbH, Dormagen- Hackenbroich, 41540, Germany|Praxis Dr. Busch, Dortmund, Dortmund, 44137, Germany|GWT-TUD GmbH, Dresden, 01307, Germany|Praxis Dr. Schlecht, Eisenach, Eisenach, 99817, Germany|ZKS Südbrandenburg GmbH, Elsterwerda, 04910, Germany|Praxis Dr. Huptas, Essen, Essen, 45307, Germany|Praxis Dr. Schmidt, Flörsheim, Flörsheim, 65439, Germany|Institut für Stoffwechselforschung, Frankfurt, Frankfurt, 60322, Germany|Praxis Dr. Groeneveld, Furth im Wald, Furth im Wald, 93437, Germany|Praxis Dr. Kohlhas, Gebhardshain, Gebhardshain, 57580, Germany|Praxis Dr. Samer, Haag, Haag, 83527, Germany|Klinische Forschung Management & Services GmbH, Hamburg, 20253, Germany|Diabetologische Schwerpunktpraxis, Hamburg, 21073, Germany|Praxis Dr. Burkhardt, Hamburg, Hamburg, 22335, Germany|Diabeteszentrum Alstertal, Hamburg, Hamburg, 22391, Germany|Praxis Dr. Herrmann, Hatten, Kirchhatten, 26209, Germany|Dünnwaldpraxis, Köln, Köln, 51069, Germany|Praxis Dr. Klein, Künzing, Künzing, 94550, Germany|Praxis Dr. Nischik, Leipzig, Leipzig, 04109, Germany|Praxis Dr. Kropp, Lübeck, Lübeck, 23554, Germany|PFÜTZNER Science & Health Institute GmbH, Mainz, 55128, Germany|Diabetologische Schwerpunktpraxis, Münster, 48153, Germany|Praxis Dr. Böckmann, Neumünster, 24534, Germany|Praxis Dr. Hilgenberg, Rehburg-Loccum, 31547, Germany|Praxis Dr. Naudts, Rodgau, Rodgau/Dudenhofen, 63110, Germany|Praxis Dr. Hirschhäuser, Saarbrücken, 66121, Germany|Praxis Dr. Segner, St. Ingberg, Saint Ingbert / Oberwürzbach, 66386, Germany|Praxis Dr. Herrmann, Schwabenheim, 55270, Germany|Praxis Dr. Dietlein, Stadtbergen, 86391, Germany|Praxis Dr. Sauter, Wangen, 88239, Germany|Schwerpunktpraxis Diabetologie, Zwenkau, 04442, Germany|General Hospital of Athens Evangelismos, Athens, 10676, Greece|General University Hospital "Attikon", Haidari, Athens, 12410, Greece|Univ. Gen. Hosp. of Ioannina, Ioannina, 45500, Greece|General Hospital "Amalia Fleming", Melissia, Athens, 15127, Greece|General Hospital of Nikaia, Nikaia, 18484, Greece|University General Hospital of Thessaloniki AHEPA, Thessaloniki, 54636, Greece|General Hopsital of Thessaloniki "Ippokrateio", Thessaloniki, 54642, Greece|Kliniki Thermi, Thessaloniki, 57001, Greece|Alice Ho Miu Ling Nethersole Hospital, Hong Kong, Hong Kong|Prince of Wales Hospital, Hong Kong, Hong Kong|Queen Mary Hospital, Hong Kong, Hong Kong|Imre Magyar Hospital, Ajka, Ajka, 8400, Hungary|Lausmed Kft. Outpatient Unit of Internal Medicine, Baja, 6500, Hungary|Karolyi Sandor Hospital, Budapest, Budapest, 1041, Hungary|Bekes County Pandy Kalman Hospital, Gyula, 5700, Hungary|Erzsebet Hospital, Hodmezövasarhely, Hódmezövásárhely, 6800, Hungary|Dr. Samuel Diosszilagyi Hospital and Outpatient Clinic, Mako, Mako, 6900, Hungary|TaNa Med Kft., Mosonmagyarovar, 9200, Hungary|Grof Esterhazy Hospital and Outpatient Clinic, Papa, 8500, Hungary|Tolna County Balassa Janos Hospital, Szekszard, 7100, Hungary|Shree Krishna Hospital and Heart Care Centre, Ahmedabad, Ahmedabad, 380052, India|CIIGMA Institute of Medical Sciences Pvt Ltd, Aurangabad, 431001, India|MS Ramaiah Memorial Hospital,, Bangalore, Karnataka, 560054, India|Diabetes care and research centre, Bangalore, 560010, India|Manipal Hospital, Bangalore, 560017, India|Bangalore Diabetes Centre (BDC)- Medisys Clinical Research, Bangalore, 560043, India|Belgaum Diabetes Centre, Belgaum, Belgaum, 590001, India|Swamy Diabetes Centre, Chennai, 600 028, India|Apollo Hospitals, Chennai, 600010, India|M V Hospital For Diabetes and Diabetes Research Centre, Chennai, 600013, India|Dr. Mohans Diabetes Speciality Centre, Chennai, 600086, India|Kovai Diabetes Speciality Centre & Hospital, Coimbatore, 641009, India|TOTALL Diabetes Hormone Institute, Indore, 452010, India|Diabetes Thyroid and Endocrine Centre, Jaipur, 302 006, India|Diamed Clinical Research Services Pvt. Ltd., Jaipur, 302016, India|Grant Medical Foundation, Ruby Hall Clinic, Maharashtra, 411001, India|K.G.N. Diabetes and Endocrine Centre, Mumbai, Maharastra, 400008, India|Global Hospital- Superspeciality & Transplant Centre, Mumbai, 400012, India|RHIDEM, Mumbai, 400014, India|Sunil's Diabetes care and Research Centre, Nagpur, 440 010, India|Jahingir Clinical Development Centre, Pune, 411001, India|Deshmukh Clinic, Pune, 411030, India|Diabetes Care Center, Thiruvananthapuram, 695 010, India|Yalamanchi Hospitals & Research Centres Pvt Ltd., Vijayawada, 520 002, India|The Red House Family Practice, Co. Cork, CORK, Ireland|Connolly Hospital Blanchardstown, Dublin, 15, Ireland|The Palms GP Surgery, Gorey, Wexford, Ireland|Fethard-on-Sea Medical Practice, Wexford, Wexford, Ireland|Barzilai Medical Center, Ashkelon, 78278, Israel|Rambam Medical Center, Haifa, 31096, Israel|Edith Wolfson Medical Center, Diabetic Unit, Holon, Holon, 58100, Israel|Hadassah Medical Center, Ein-Karem, Jerusalem, 91120, Israel|Western Galilee Hospital, Nahariya, 22100, Israel|The Chaim Sheba Medical Center Tel Hashomer, Tel Hashomer, 52621, Israel|Sourasky Medical Center, Tel-Aviv, 64239, Israel|Ospedale "SS. Trinità", Cagliari, 09100, Italy|Policlinico Universitario Mater Domini, Universita di Catanzaro, Catanzaro, 88100, Italy|Policlinico San Martino, Genova, 16132, Italy|Ospedale di Guastalla, Guastalla (RE), 42016, Italy|A.O.U.Policlinico G.Martino, Messina, 98125, Italy|Fondazione Centro San Raffaele del Monte Tabor, Milano, 20132, Italy|Ospedale S. Pertini, Roma, 00100, Italy|Azienda Ospedaliera Sant'Andrea-Università di Roma La Sapienza, Roma, 00189, Italy|IRCCS Gruppo Multimedica, Sesto San Giovanni (MI), 20099, Italy|Daishinkai Medical Corporation Ookuma Hospital, Aichi, Nagoya, 462-0825, Japan|Chibanishi General Hospital, Chiba, Matsudo, 270-2251, Japan|New Tokyo Heart Clinic, Chiba, Matsudo, 271-0077, Japan|Kashinoki I.M. Clinic, Fukushima, I.M., Fukushima, Date, 960-0418, Japan|Japan Community Health care Organization Nihonmatsu Hospital, Fukushima, Nihonmatsu, 964-8501, Japan|Iwase General Hospital, Fukushima, Sukagawa, 962-8503, Japan|Iryohojinshadan Sasaki Clinic, Hyogo, Amagasaki, 660-0827, Japan|Takasagoseibu Hospital, Hyogo, Takasago, 676-0812, Japan|Kanagawa Cardiovascular and Respiratory Center, Kanagawa, Yokohama, 236-0051, Japan|Jinnouchi Clinic Diabetes Care Center, Kumamoto, Kumamoto, 862-0976, Japan|Kumamoto Rosai Hospital, Kumamoto, Yatsushiro, 866-8533, Japan|Koga General Hospital, Miyazaki, Miyazaki, 880-0041, Japan|Saitama Medical Cooperative Association Hanyu General Hospital, Saitama, Hanyu, 348-0045, Japan|Nihon University Itabashi Hospital, Tokyo, Itabashi-ku, 173-8610, Japan|Korea University Ansan Hospital, Ansan, 15355, Korea, Republic of|Inje University Busan Paik Hospital, Busan, 614-735, Korea, Republic of|Keimyung University Dongsan Medical Center, Daegu, 700-712, Korea, Republic of|National Health Insurance Service Ilsan Hospital, Goyang, 410-719, Korea, Republic of|Dongguk University Ilsan Hospital, Goyang, 410-773, Korea, Republic of|Inje University Ilsan Paik Hospital, Goyang, 411-706, Korea, Republic of|Chonbuk National University Hospital, Jeonju, 561-712, Korea, Republic of|Pusan National Univ. Hosp, Pusan, 602-739, Korea, Republic of|Seoul National University Bundang Hospital, Seongnam, 463-707, Korea, Republic of|Korea University Anam Hospital, Seoul, 02841, Korea, Republic of|Korea University Guro Hospital, Seoul, 08308, Korea, Republic of|Kangdong Sacred Heart Hospital, Seoul, 134-701, Korea, Republic of|Ajou University Hospital, Suwon, 443-380, Korea, Republic of|Wonju Severance Christian Hosp, Wonju, 220-701, Korea, Republic of|Pusan National University Yangsan Hospital, Yangsan, 626-770, Korea, Republic of|Monash University, Johor Bahru, Johor, 80100, Malaysia|Hospital University Sains Malaysia, Kota Bharu, 16150, Malaysia|Hospital Kuala Lumpur, Kuala Lumpur, 50586, Malaysia|University Malaya Medical Centre, Kuala Lumpur, 59100, Malaysia|Hospital Tengku Ampuan Afzan, Kuantan, 25100, Malaysia|Hospital Melaka, Melaka, 75400, Malaysia|Penang Medical College, Penang, 10450, Malaysia|Hospital Taiping, Taiping, 34000, Malaysia|Hospital General de Acapulco, Acapulco, 39570, Mexico|Centro de Investigacion Cardiometabolica de Aguascalientes, Aguascalientes, 20234, Mexico|Instituto Nacional de Cardiologia Ignacio Chavez, Distrito Federal, 14080, Mexico|Unidad de Investigacion Clinica Cardiometabolica de Occident, Guadalajara, 44150, Mexico|Hospital Universitario Dr Jose Eleuterio Gonzalez, Monterrey, 64460, Mexico|Huisartspraktijk Emmers, 's-hertogenbosch, 5235 KG, Netherlands|FlevoResearch, Almere, 1311 RL, Netherlands|Academisch Medisch Centrum (AMC), Amsterdam, 1105 AZ, Netherlands|Rode Kruis Ziekenhuis Beverwijk, Beverwijk, 1942 LE, Netherlands|Andromed Breda, Breda, 4811 SW, Netherlands|Noordwest Ziekenhuisgroep, location Den Helder, Den Helder, 1782 GZ, Netherlands|Andromed Eindhoven, Eindhoven, 5611 NV, Netherlands|Andromed Noord, Groningen, 9711 SG, Netherlands|Vasculair Onderzoek Centrum, Hoorn, 1624 NP, Netherlands|Maastricht Universitair Medisch Centrum, Maastricht, 6229 HX, Netherlands|Andromed Rotterdam, Rotterdam, 3039 BD, Netherlands|Rotterdam Research Institute, Rotterdam, 3039 BD, Netherlands|Ikazia Ziekenhuis, Rotterdam, 3083 AN, Netherlands|Antonius Ziekenhuis, Sneek, 8601 ZK, Netherlands|Andromed Oost, Velp, 6883 ES, Netherlands|Andromed Leiden-Zoetermeer, Zoetermeer, 2724 EK, Netherlands|Christchurch Hospital, Christchurch, 4710, New Zealand|RMC Medical Research Ltd, Dunedin, 9012, New Zealand|P3 Research, Wellington, Newtown Wellington NZ, 6021, New Zealand|P3 Research, Promed House, Tauranga, 3110, New Zealand|Bodø Legesenter AS, avd. for med. studier, Bodø, N-8001, Norway|Medi 3 Innlandet AS, avd Elverum, Elverum, N-2408, Norway|Vestre Viken HF, Bærum sykehus, Gjettum, N-1346, Norway|M3 Helse AS, Hamar, N-2317, Norway|Bylegene SA, Jessheim, N-2050, Norway|Heiaklinikken, Lierskogen, N-3420, Norway|Rådhuset Spesialistsenter, Oslo, N-0160, Norway|Sandvika Spesialistsenter, Sandvika, N-1337, Norway|Grålum Legesenter, Sarpsborg, N-1727, Norway|Forusakutten - Kolibri Medical, Avd. Stavanger, Stavanger, N-4005, Norway|Medi 3 AS, Ålesund, N-6002, Norway|Instituto Delgado de Investigacion Medica, Arequipa, LIMA 54, Peru|Clinica San Pedro, Huacho, Peru|Hospital Nacional Dos de Mayo, Lima, 01, Peru|Clinica Internacional, Lima, LIMA 1, Peru|Centro de Investigaciones Médicas METABOLICARE SAC, Lima, Lima 27, Peru|Clinica San Gabriel, Lima, Lima 32, Peru|Centro De Especialidades Medicas Santa Maria S.A.C, Piura, Peru|Clinica San Judas Tadeo, San Miguel, 32, Peru|Center for Diabetes Care, Iloilo, 5000, Philippines|Mary Mediatrix Medical Center, Lipa City, Batangas, 4217, Philippines|Philippine General Hospital, Manila, 1000, Philippines|University of Santo Tomas Hospital, Manila, 1008, Philippines|Manila Doctors Hospital, Manila, 1011, Philippines|Asian Hospital & Medical Center, Muntinlupa, 1781, Philippines|St. Luke's Medical Center, Quezon City, 1102, Philippines|Quirino Memorial Medical Center, Quezon City, 1109, Philippines|Cardinal Santos Medical Center, San Juan, 1503, Philippines|Surigao Health Specialists, Surigao, 8400, Philippines|Hospital Fernando Fonseca, EPE, Amadora, 2700-276, Portugal|CHLO, EPE - Hospital de Santa Cruz, Carnaxide, 2799-523, Portugal|CHUC - Centro Hospitalar e Universitário de Coimbra, EPE, Coimbra, 3000-075, Portugal|Centro Hospitalar da Cova da Beira Hospital Pêro da Covilhã, Covilhã, 6200-251, Portugal|Hospital Distrital Figueira da Foz, EPE, Figueira da Foz, 3094-001, Portugal|Hospital da Luz, Lisboa, 1500-650, Portugal|Centro Hospitalar São João,EPE, Porto, 4202-451, Portugal|Centro Hospitalar de Entre o Douro e Vouga, E.P.E. - Hospital de São Sebastião, Santa Maria da Feira, 4520-211, Portugal|SC Diabol SRL, Brasov, Brasov, 500365, Romania|Nicodiab SRL, Bucharest, Bucharest, 010507, Romania|SC Medical Centre "Sanatatea Ta" SRL, Bucharest, Bucharest, 020614, Romania|Consultmed SRL, Iasi, Iasi, 700547, Romania|Emergency County Clinical Hospital, Sibiu, Sibiu, 550245, Romania|Private Practice Dr. Remus Gagiu, Tirgoviste, 130083, Romania|LLC Clinic of new technologies of medicine, Dzerzhinsky, 140091, Russian Federation|City Clinical Hospital No. 6 of MoH of Udmurt Republic, Izhevsk, 436000, Russian Federation|City Clinical Hospital No. 4, Moscow, Moscow, 115093, Russian Federation|City Clinical Hospital No. 13, Moscow, Moscow, 115280, Russian Federation|State Institution "Central Clinical Hospital of RAS", Moscow, Moscow, 117333, Russian Federation|City Clinical Hospital No. 61, Moscow, Moscow, 119048, Russian Federation|State Healthcare Institution, Regional hospital #2, Rostov-na-Donu, 344029, Russian Federation|Limited Liability Company "CENTER DIABET", Samara, Samara, 443067, Russian Federation|MMU City Outpatient Clinic no. 20, Saratov, Saratov, 410018, Russian Federation|Clinical Medical Center Zvezdara, Belgrade, Belgrade, 11000, Serbia|Clinical Centre Nis, Nis, 18000, Serbia|General Hospital Pancevo, Pancevo, 26000, Serbia|General Hospital Subotica, Internal Medicine, Subotica, 24000, Serbia|Clinical Hospital Center Zemun, Zemun, 11080, Serbia|DIASTYLE s.r.o., Diabetology Outpatient Department, Banska Bystrica, 974 01, Slovakia|ENDIAMED s.r.o., Dolny Kubin, Dolny Kubin, 026 01, Slovakia|CELL B s.r.o., Levice, 934 01, Slovakia|DIA-KONTROL s.r.o., Levice, 934 01, Slovakia|Funkystuff s.r.o., Nove Zamky, Nove Zamky, 940 01, Slovakia|Diabetologicka ambulancia MUDr. Lucia Gajdosikova s.r.o., Povazska Bystrica, 017 01, Slovakia|MEDIVASA s.r.o., Outpatient Clinic, Zilina, Zilina, 010 01, Slovakia|Dr. P. Patel, Cape Town, 7764, South Africa|Dr. E. L. Janari, Cape Town, 7965, South Africa|Dr. Vawda, Durban, 4091, South Africa|Parklands Medical Centre, Durban, 4091, South Africa|Dr. Jurgens, Krugersdorp, 1739, South Africa|Dr. H. Makan, Lenasia, 1827, South Africa|Dr. D. R. Lakha, Johannesburg, Lenasia, 2033, South Africa|Greenacres Hospital, Port Elizabeth, 6045, South Africa|Dr. M. Seeber, Pretoria, 0083, South Africa|Vergelegen Medi-Clinic, Somerset West, 7130, South Africa|C.A.P. Sardenya, Barcelona, 08025, Spain|CAP Les Corts, Barcelona, 08028, Spain|CAP Casanova, Barcelona, 08036, Spain|CAP Burjassot 1, Burjassot, 46100, Spain|C.S. Natahoyo, Gijon, 33212, Spain|Hospital Universitari de Girona Doctor Josep Trueta, Girona, 17007, Spain|CAP Florida, L'Hospitalet de Llobregat, 08905, Spain|Hospital de Bellvitge, L'Hospitalet de Llobregat, 08907, Spain|CAP La Roca, La Roca Del Vallés (Barcelona), 08430, Spain|Hospital General Universitario Gregorio Marañón, Madrid, 28007, Spain|C.S. El Cristo, Oviedo, 33006, Spain|C.S. Colloto, Oviedo, 33010, Spain|C.S. Vallobin-La Florida, Oviedo, 33012, Spain|ABS Pineda de Mar, Pineda de Mar, 08397, Spain|Hospital de l'Esperit Sant, Santa Coloma De Gramanet, 08923, Spain|CAP Tàrrega, Tàrrega, 25300, Spain|CS Ingeniero Joaquin Benlloch, Valencia, 46006, Spain|Hospital Clínico de Valencia, Valencia, 46010, Spain|CTC Sahlgrenska Universitetssjukhuset, Göteborg, 413 45, Sweden|Sjukhuset, Härnösand, Härnösand, 87182, Sweden|Avonova Hälsa AB, Järfälla, 177 30, Sweden|Skånes universitetssjukhus, Malmö, Malmö, 20502, Sweden|Dalecarlia Clinical Research Center, Rättvik, 795 30, Sweden|Södra Dalarnas vårdcentral, Hedemora, Rättvik, 79530, Sweden|Näsets Läkargrupp, Skanör, 239 33, Sweden|Vårdcentralen Silentzvägen, Uddevalla, 451 50, Sweden|S3 Clinical Research Centers, Vällingby, 162 68, Sweden|Allgemeine Medizin, Basel, 4057, Switzerland|FMH endocrinologia diabetologia, Bellinzona, 6500, Switzerland|Inselspital Bern, Bern, 3010, Switzerland|Dr. Pietro Gerber, Lugano, 6900, Switzerland|Chang-Hua Christian Hospital, Changhua, 500, Taiwan|Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, 807, Taiwan|E-Da Hospital, Kaohsiung, 824, Taiwan|Far Eastern Memorial Hospital, New Taipei City, 220, Taiwan|Taichung Veterans General Hospital, Taichung,, 40705, Taiwan|China Medical University Hospital, Taichung, 40447, Taiwan|NCKUH, Tainan, 704, Taiwan|National Taiwan University Hospital, Taipei, 100, Taiwan|Shih-Kong Wu Ho-Shu Memorial Hospital, Taipei, 111, Taiwan|Taipe Veterans General Hospital, Taipei, 11217, Taiwan|Cheng Hsin General Hospital, Taipei, 112, Taiwan|Tri-Service General Hospital, Taipei, 114, Taiwan|Cardinal Tien Hospital, Taipei, 23137, Taiwan|Taipei Medical University-Shuang Ho Hospital, Taipei, 235, Taiwan|Mackay Memorial Hospital, Taipei, 25160, Taiwan|HOP Fattouma Bourguiba, Mint, Monastir, Monastir, 5000, Tunisia|HOP Hédi Chaker, Endo, Sfax, Sfax, 3029, Tunisia|HOP Farhat Hached, Mint, Sousse, Sousse, 4000, Tunisia|HOP Habib Thameur, Mint, Tunis, Tunis, 1008, Tunisia|Donetsk Regional Clinical Hosp, Therapy Department, Donetsk, 83003, Ukraine|Ivano-Frankivsk City Central Clinical Hospital, Ivano-Frankivsk, 76000, Ukraine|City Clinical Hospital No. 17, Kharkov, Kharkiv, 61037, Ukraine|City Clinical Hospital No. 27, Kharkiv, Kharkov, 61002, Ukraine|Clinic for Cardiology "Sertse i sudyny", Kiev, Kiev, 01032, Ukraine|City Clinical Hospital No. 1, Kiev, Kiev, 02091, Ukraine|Poliklinika #2, Kyiv, Kyiv, 02002, Ukraine|City Hospital No. 5, Lvov, Lvov, 73013, Ukraine|Odeska zaliznichna likarnya, Odessa, Odesa, 65039, Ukraine|Vinnitsia Regional Endocrinology Dispensary, Vinnitsa, 21010, Ukraine|Crouch Oak Family Practice, Addlestone, KT15 2BH, United Kingdom|Ash Vale Health Centre, Aldershot, Ash Vale, Aldershot, GU12 5BA, United Kingdom|Birmingham Heartlands Hospital, Birmingham, B9 5SS, United Kingdom|Hathaway Medical Centre, Chippenham, SN14 6GT, United Kingdom|University Hospital of North Durham, Durham, DH1 5TW, United Kingdom|St Mary's Surgery, Ely, CB7 4HF, United Kingdom|Gloucestershire Royal Hospital, Gloucester, GL1 3NN, United Kingdom|James Paget University Hospital, Great Yarmouth, NR31 6LA, United Kingdom|Morriston Hospital, Swansea, SA6 6NL, United Kingdom|Royal Cornwall Hospital, Truro, TR1 3LJ, United Kingdom
URL: https://clinicaltrials.gov/show/NCT01243424

Drug ID Drug Name Type DrugBank ID Targets Category Latest Progress