| Outcome Measures: |
Primary: Pharmacokinetics parameters of SHR3824 in the fast and fed state: Cmax, Based on pre-dose, 0.25-72 hours post-dose sampling times on Day 1 and Day 8|Pharmacokinetics parameters of SP2086 in the fast and fed state: Cmax, Based on pre-dose, 0.25-72 hours post-dose sampling times on Day 1 and Day 8|Pharmacokinetics parameters of Metformin in the fast and fed state: Cmax, Based on pre-dose, 0.25-72 hours post-dose sampling times on Day 1 and Day 8|Pharmacokinetics parameters of SHR3824 in the fast and fed state: AUC0-t, Based on pre-dose, 0.25-72 hours post-dose sampling times on Day 1 and Day 8|Pharmacokinetics parameters of SP2086 in the fast and fed state: AUC0-t, Based on pre-dose, 0.25-72 hours post-dose sampling times on Day 1 and Day 8|Pharmacokinetics parameters of Metformin in the fast and fed state: AUC0-t, Based on pre-dose, 0.25-72 hours post-dose sampling times on Day 1 and Day 8|Pharmacokinetics parameters of SHR3824 in the fast and fed state: AUC0-inf (if applicable), Based on pre-dose, 0.25-72 hours post-dose sampling times on Day 1 and Day 8|Pharmacokinetics parameters of SP2086 in the fast and fed state: AUC0-inf (if applicable), Based on pre-dose, 0.25-72 hours post-dose sampling times on Day 1 and Day 8|Pharmacokinetics parameters of Metformin in the fast and fed state: AUC0-inf (if applicable), Based on pre-dose, 0.25-72 hours post-dose sampling times on Day 1 and Day 8 | Secondary: Pharmacokinetics parameters of SP2086A in the fast and fed state: Cmax, Based on pre-dose, 0.25-72 hours post-dose sampling times on Day 1 and Day 8|Pharmacokinetics parameters of SP2086A in the fast and fed state: AUC0-t, Based on pre-dose, 0.25-72 hours post-dose sampling times on Day 1 and Day 8|Pharmacokinetics parameters of SP2086A in the fast and fed state: AUC0-inf (if applicable), Based on pre-dose, 0.25-72 hours post-dose sampling times on Day 1 and Day 8|Pharmacokinetics parameters of SHR3824 in the fast and fed state: Tmax, Based on pre-dose, 0.25-72 hours post-dose sampling times on Day 1 and Day 8|Pharmacokinetics parameters of SP2086 in the fast and fed state: Tmax, Based on pre-dose, 0.25-72 hours post-dose sampling times on Day 1 and Day 8|Pharmacokinetics parameters of SP2086A in the fast and fed state: Tmax, Based on pre-dose, 0.25-72 hours post-dose sampling times on Day 1 and Day 8|Pharmacokinetics parameters of Metformin in the fast and fed state: Tmax, Based on pre-dose, 0.25-72 hours post-dose sampling times on Day 1 and Day 8|Pharmacokinetics parameters of SHR3824 in the fast and fed state: Vz/F, Based on pre-dose, 0.25-72 hours post-dose sampling times on Day 1 and Day 8|Pharmacokinetics parameters of SP2086 in the fast and fed state: Vz/F, Based on pre-dose, 0.25-72 hours post-dose sampling times on Day 1 and Day 8|Pharmacokinetics parameters of SP2086A in the fast and fed state: Vz/F, Based on pre-dose, 0.25-72 hours post-dose sampling times on Day 1 and Day 8|Pharmacokinetics parameters of Metformin in the fast and fed state: Vz/F, Based on pre-dose, 0.25-72 hours post-dose sampling times on Day 1 and Day 8|Pharmacokinetics parameters of SHR3824 in the fast and fed state: CL/F, Based on pre-dose, 0.25-72 hours post-dose sampling times on Day 1 and Day 8|Pharmacokinetics parameters of SP2086 in the fast and fed state: CL/F, Based on pre-dose, 0.25-72 hours post-dose sampling times on Day 1 and Day 8|Pharmacokinetics parameters of SP2086A in the fast and fed state: CL/F, Based on pre-dose, 0.25-72 hours post-dose sampling times on Day 1 and Day 8|Pharmacokinetics parameters of Metformin in the fast and fed state: CL/F, Based on pre-dose, 0.25-72 hours post-dose sampling times on Day 1 and Day 8|Pharmacokinetics parameters of SHR3824 in the fast and fed state: t1/2, Based on pre-dose, 0.25-72 hours post-dose sampling times on Day 1 and Day 8|Pharmacokinetics parameters of SP2086 in the fast and fed state: t1/2, Based on pre-dose, 0.25-72 hours post-dose sampling times on Day 1 and Day 8|Pharmacokinetics parameters of SP2086A in the fast and fed state: t1/2, Based on pre-dose, 0.25-72 hours post-dose sampling times on Day 1 and Day 8|Pharmacokinetics parameters of Metformin in the fast and fed state: t1/2, Based on pre-dose, 0.25-72 hours post-dose sampling times on Day 1 and Day 8|The incidence and severity of adverse events/serious adverse events, From signed the informed consent form to Day 15 safety visit
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