| Trial ID: | L3567 |
| Source ID: | NCT00771901
|
| Associated Drug: |
Tauroursodeoxycholic Acid
|
| Title: |
Effect of Endoplasmic Reticulum Stress on Metabolic Function
|
| Acronym: |
TUDCA/PBA
|
| Status: |
COMPLETED
|
| Study Results: |
YES
|
| Results: |
https://ClinicalTrials.gov/show/NCT00771901/results
|
| Conditions: |
Insulin Resistance|Diabetes|Obesity
|
| Interventions: |
DRUG: tauroursodeoxycholic acid|OTHER: placebo|DRUG: sodium phenylbutyrate
|
| Outcome Measures: |
Primary: Body Composition, Fat mass (%), Baseline and four weeks | Secondary: Insulin Sensitivity in the Liver, HISI (hepatic insulin sensitivity index). HISI is the inverse of the product of endogenous glucose production and plasma insulin concentration and provides an index of how well circulating insulin controls the amount of glucose supplied by the liver. A higher number is indicative of greater insulin sensitivity., Baseline and four weeks|VLDL-triglyceride (TG) Concentration, Baseline and four weeks
|
| Sponsor/Collaborators: |
Sponsor: Washington University School of Medicine
|
| Gender: |
ALL
|
| Age: |
ADULT, OLDER_ADULT
|
| Phases: |
|
| Enrollment: |
101
|
| Study Type: |
INTERVENTIONAL
|
| Study Designs: |
Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
|
| Start Date: |
2008-02
|
| Completion Date: |
2014-12
|
| Results First Posted: |
2018-05-29
|
| Last Update Posted: |
2018-05-29
|
| Locations: |
Washington University School of Medicine, Saint Louis, Missouri, 63110, United States
|
| URL: |
https://clinicaltrials.gov/show/NCT00771901
|
