| Outcome Measures: |
Primary: Area under the serum insulin concentration time curve from 0 to 10 minutes after a 25 g glucose bolus i.v. infusion (IVGTT,intravenous glucose tolerance test) over 2 minutes, Day -1, day 86|Area under the serum insulin concentration time curve from 10-120 minutes after a 25 g glucose bolus i.v. infusion (IVGTT)., Day -1, day 86 | Secondary: Area under the insulin secretion rate (ISR)-time curve within 0 to 10 min after i.v. glucose challenge, Day -1, day 86|Area under the ISR-time curve within 10 to 120 min after i.v. glucose challenge, Day -1, day 86|24-hour plasma glucose, glucagon, serum insulin, and C-peptide measured as total AUC0-24h during a test day with 3 standardised meals, Day -1, day 85|Area under the insulin secretion rate (ISR)-time curve within 0 to 10 min after i.v. arginine application; ISR will be derived from the C-peptide concentration profile, Day -1, day 86|Area under the ISR curve over the 5-12 mmol/L (90-216 mg/dL) glucose interval; ISR will be derived from the C-peptide concentration profile, Day -1, day 87|Slope of the ISR vs. glucose curve (dose-response relationship), Day -1, day 87
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