| Trial ID: | L3735 |
| Source ID: | NCT02697201
|
| Associated Drug: |
Intralipid
|
| Title: |
Dynamics of Muscle Mitochondria in Type 2 Diabetes (DYNAMMO T2D)
|
| Acronym: |
DYNAMMO-T2D
|
| Status: |
COMPLETED
|
| Study Results: |
NO
|
| Results: |
|
| Conditions: |
Insulin Resistance
|
| Interventions: |
DRUG: Intralipid|DRUG: Saline
|
| Outcome Measures: |
Primary: Effects of lipid infusion on mitochondrial fission, Fission will be assessed from quantitative measures of dynamin-related protein-1. The unit of assessment is arbitrary units of blot intensity and is expressed as AU., 5 years | Secondary: Effects of lipid infusion on mitochondrial function, Function will be assessed from oxygen consumption. Unit of assessment is pmol/s/mg of muscle., 5 years|Insulin sensitivity, Insulin sensitivity will be assessed by euglycemic hyperinsulinemic clamp. Units of assessment are mg/kg/min., 5 years
|
| Sponsor/Collaborators: |
Sponsor: Pennington Biomedical Research Center
|
| Gender: |
ALL
|
| Age: |
ADULT
|
| Phases: |
EARLY_PHASE1
|
| Enrollment: |
25
|
| Study Type: |
INTERVENTIONAL
|
| Study Designs: |
Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
|
| Start Date: |
2016-07
|
| Completion Date: |
2021-05
|
| Results First Posted: |
|
| Last Update Posted: |
2021-07-27
|
| Locations: |
Pennington Biomedical Research Center, Baton Rouge, Louisiana, 70808, United States
|
| URL: |
https://clinicaltrials.gov/show/NCT02697201
|
