| Trial ID: | L3802 |
| Source ID: | NCT03018444
|
| Associated Drug: |
Atorvastatin
|
| Title: |
The Effect of HMG-CoA Reductase Inhibition on Postprandial GLP-1 Secretion
|
| Acronym: |
|
| Status: |
COMPLETED
|
| Study Results: |
NO
|
| Results: |
|
| Conditions: |
Diabetes Mellitus, Type 2|Hydroxymethylglutaryl-CoA Reductase Inhibitors
|
| Interventions: |
DRUG: Atorvastatin|OTHER: Placebo
|
| Outcome Measures: |
Primary: Postprandial GLP-1 secretion, 240 min | Secondary: Postprandial Bile Acid Composition, 240 min|Postprandial total plasma Bile Acid, 240 min|Postprandial Glucose Tolerance, 240 min|Postprandial plasma lipid response, 240 min|Postprandial GIP secretion, 240 min|Enteric hormones known to influence glucose metabolism, 240 min|Gallbladder emptying, 240 min|Faecal content of bile acid, One sample collected on day 12 or 13 of the intervention|Gut microbiota composition, One sample collected on day 12 or 13 of the intervention|Gastric emptying, 240 min|Resting Energy Expenditure, At time -20 min, +60 min and +220 min
|
| Sponsor/Collaborators: |
Sponsor: University Hospital, Gentofte, Copenhagen
|
| Gender: |
MALE
|
| Age: |
ADULT, OLDER_ADULT
|
| Phases: |
|
| Enrollment: |
15
|
| Study Type: |
INTERVENTIONAL
|
| Study Designs: |
Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
|
| Start Date: |
2016-10
|
| Completion Date: |
2017-01
|
| Results First Posted: |
|
| Last Update Posted: |
2017-03-03
|
| Locations: |
University Hospital, Gentofte, Copenhagen, Hellerup, Region Hovedstaden, 2900, Denmark
|
| URL: |
https://clinicaltrials.gov/show/NCT03018444
|
