| Outcome Measures: |
Primary: Pancreatic Fat Content, Pancreatic fat content was determined by proton magnetic resonance spectroscopy (1H-MRS) using a 1.5 Tesla Philips Intera system., 12 months|Bone Turnover Marker - Intact Parathyroid Hormone (PTH), Intact parathyroid hormone (PTH) were measured using enzyme-linked immunosorbent assay. ., 12 months|Bone Turnover Marker - Plasma 25-hydroxyvitamin D, Plasma 25-hydroxyvitamin D was determined by radioimmunoassay, 12 months | Secondary: Beta-cell Function, Changes in B-cell function as measured by acute insulin release to glucose (AIRg), 12 months|Hepatic Fat Content, Hepatic fat content was determined by proton magnetic resonance spectroscopy (1H-MRS) using a 1.5 Tesla Philips Intera system., 12 months|Subcutaneous Fat Area, Abdominal MRI was performed to quantify subcutaneous fat area at the L2-L3 level., 12 months|Visceral Fat Area, Abdominal MRI was performed to quantify visceral fat area at the L2-L3 level., 12 months|Bone Mineral Density, Areal Bone Mineral Density at the L2-L4 antero-posterior lumbar spine, left femoral neck and total hip were measured by DXA scan using a Hologic Discovery Instrument scanner., 12 months|Disposition Index, Disposition index is a measure of insulin secretion multiplied by insulin sensitivity, both derived from intravenous glucose tolerance test. A higher number means the pancreas is better able to lower blood glucose and a lower number means the pancreas is less able to lower blood glucose, 12 months
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