| Trial ID: | L3852 |
| Source ID: | NCT03705195
|
| Associated Drug: |
Gliclazide
|
| Title: |
Study of Sulphonylurea Synergy With Incretins
|
| Acronym: |
LOGIC
|
| Status: |
COMPLETED
|
| Study Results: |
NO
|
| Results: |
|
| Conditions: |
Type 2 Diabetes Mellitus
|
| Interventions: |
DRUG: Gliclazide
|
| Outcome Measures: |
Primary: Difference in insulin secretion and incretin effect between two matched clamps (presence and absence of low dose gliclazide), Comparison of two matched clamps (oral glucose tolerance test + isoglycaemic intravenous glucose infusion). Matched clamp 1 - control. Matched clamp 2 - low dose gliclazide. Levels of insulin/c-peptide, incretin hormones and plasma glucose will be compared in the presence and absence of low dose gliclazide, Through four study visits completed over 4 weeks | Secondary: Insulin secretory response analysed by KCNJ11 Genotype (E23K, E23E, K23K), Difference in insulin secretory response to low dose gliclazide calculated by insulin/cpeptide levels in matched clamp(gliclazide). Differences will then be compared by participants genotype e.g. insulin secretory response for E23K, E23E, K23K variants., Through four study visits completed over 4 weeks
|
| Sponsor/Collaborators: |
Sponsor: University of Dundee | Collaborators: NHS Tayside
|
| Gender: |
ALL
|
| Age: |
ADULT, OLDER_ADULT
|
| Phases: |
|
| Enrollment: |
20
|
| Study Type: |
INTERVENTIONAL
|
| Study Designs: |
Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
|
| Start Date: |
2018-08-03
|
| Completion Date: |
2019-06-26
|
| Results First Posted: |
|
| Last Update Posted: |
2020-02-24
|
| Locations: |
Ninewells Hospital and Medical School, Dundee, DD1 9SY, United Kingdom
|
| URL: |
https://clinicaltrials.gov/show/NCT03705195
|
