| Outcome Measures: |
Primary: Glycated Hemoglobin, up to 24th months of treatment | Secondary: Percentage of patients in remission ( EULAR Criteria ), baseline , after 3 months, 6 months , 12 months and 24 months of treatment|Percentage of patients improved ( EULAR criteria), baseline , after 3 months, 6 months , 12 months and 24 months of treatment|Count of tender joints (66 joints), baseline , after 3 months, 6 months , 12 months and 24 months of treatment|Count of swollen joints (68 joints), baseline , after 3 months, 6 months , 12 months and 24 months of treatment|Administration at Health Assessment Questionnaire ( HAQ), baseline , after 3 months, 6 months , 12 months and 24 months of treatment|C-reactive protein (CRP) and erythrocyte sedimentation rate ( ESR ), baseline , after 3 months, 6 months , 12 months and 24 months of treatment:|Plasma levels of glucose, baseline , after 3 months, 6 months , 12 months and 24 months of treatment
|
