| Trial ID: | L0405 |
| Source ID: | NCT00874432
|
| Associated Drug: |
Angiotensin Converting Enzyme Inhibitor
|
| Title: |
Effect of ACE-inhibitors on Aortic Stiffness in Elderly Patients With Chronic Kidney Disease
|
| Acronym: |
|
| Status: |
COMPLETED
|
| Study Results: |
YES
|
| Results: |
https://ClinicalTrials.gov/show/NCT00874432/results
|
| Conditions: |
Cardiovascular Disease|Chronic Kidney Disease
|
| Interventions: |
DRUG: angiotensin converting enzyme inhibitor|DRUG: lisinopril
|
| Outcome Measures: |
Primary: Aortic Pulse Wave Velocity (PWV), PWV will be measured in patients over age 60 with stage 3 CKD and age matched controls without CKD., up to 12 months | Secondary: Mean Vascular Stiffness As Measured by PWV, Comparison between Participants with Stage 3 Chronic Kidney Disease (CKD) and age matched Controls without CKD. The numbers reported are the mean of all the participants in the group at two points in time - the baseline and at 12 months for CFPWV, CBPWV, and CRPWV. Carotid-Femoral Pulse Wave Velocity (CFPWV) Carotid-Brachial Pulse Wave Velocity (CBPWV) Carotid-Radial Pulse Wave Velocity (CRPWV), baseline and 12 months|Change in Blood Pressure From Baseline to 12 Months, Change in Blood Pressure will be used to measure the effect of ACE-inhibitors on the clinical markers of Cardiovascular Disease in participants with stage 3 CKD., up to 12 months
|
| Sponsor/Collaborators: |
Sponsor: University of Wisconsin, Madison
|
| Gender: |
ALL
|
| Age: |
ADULT, OLDER_ADULT
|
| Phases: |
PHASE2
|
| Enrollment: |
43
|
| Study Type: |
INTERVENTIONAL
|
| Study Designs: |
Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
|
| Start Date: |
2009-01
|
| Completion Date: |
2011-12
|
| Results First Posted: |
2020-09-23
|
| Last Update Posted: |
2020-10-27
|
| Locations: |
University of Wisconsin-Madison Hospitals and Clinics, Madison, Wisconsin, 53792, United States
|
| URL: |
https://clinicaltrials.gov/show/NCT00874432
|
