| Outcome Measures: |
Primary: Change of fasting plasma glucose (FPG,mmol/L), Baseline, 24weeks (End of Trial)|Change of OGTT 2 hour blood glucose(mmol/L), Baseline, 24weeks (End of Trial)|Change of HbA1c(%), Baseline, 24weeks (End of Trial)|Change of control rate of blood glucose(%), Baseline, 24weeks (End of Trial) | Secondary: Change of insulin release(uU/mL), Baseline, 24weeks (End of Trial)|Change of C peptide release(nmol/L), Baseline, 24weeks (End of Trial)|Change of HOMA-β[HOMA-β=20×（FINS,mIU/L）/（（FPG,mmol/L）-3.5）], Baseline, 24weeks (End of Trial)|Change of HOMA-IR [HOMA-IR=(FPG,mmol/L）×（FINS,mIU/L）/22.5], Baseline, 24weeks (End of Trial)|Change of blood glucose variability(%), Baseline, 24weeks (End of Trial)|Change of triglyceride(mmol/L）, Baseline, 24weeks (End of Trial)|Change of total cholesterol(mmol/L）, Baseline, 24weeks (End of Trial)|Change of LDL-c(mmol/L）, Baseline, 24weeks (End of Trial)|Change of HDL-c(mmol/L）, Baseline, 24weeks (End of Trial)|Change of Glucagon(pg/ml)., Baseline, 24weeks (End of Trial)|Change of GLP(pg/ml)., Baseline, 24weeks (End of Trial)|Change of GIP(pg/ml)., Baseline, 24weeks (End of Trial)|Change of DPP-IV(pg/ml)., Baseline, 24weeks (End of Trial)|Change of waist circumference (WC,cm), Baseline, 24weeks (End of Trial)|Change of body mass index (BMI=weight(kg)/[height(m)2], kg/m2), Baseline, 24weeks (End of Trial)|Change of body fat(%)., Baseline, 24weeks (End of Trial)|Change of carotid intima-media thickness (IMT,mm)., Baseline, 24weeks (End of Trial)|Change of 24-hours urine sodium(mmol/24h), Baseline, 24weeks (End of Trial)|Change of 24-hours microalbumin(mg/L)., Baseline, 24weeks (End of Trial)|Change of 24-hours mALB/Cr(mg/g.Cr)., Baseline, 24weeks (End of Trial)|Change of inflammatory markers(hs-CRP,mg/L)., Baseline, 24weeks (End of Trial)|Incidence rate of newly-diagnosed hypertension(%)., Baseline, 24weeks (End of Trial)|Heart rate variability(HRV,%)., Baseline, 24weeks (End of Trial)|Change of clinic blood pressure and 24h mean blood pressure(mmHg)., Baseline, 24weeks (End of Trial)
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