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Clinical Trial Details

Trial ID: L4294
Source ID: NCT02509858
Associated Drug: Thyroxine
Title: The Effect of Administration of Small Doses of Thyroxine on Glucose and Lipid Metabolism, in Type 2 Diabetes Mellitus.
Acronym:
Status: COMPLETED
Study Results: NO
Results:
Conditions: Diabetes Mellitus
Interventions: DRUG: thyroxine|DRUG: Placebo|OTHER: A meal (730kcal, 50%carbohydrate, of which 38% was starch, 40% fat, and 10% protein)
Outcome Measures: Primary: area under the glucose uptake versus time curve-AUC, Muscle glucose uptake following meal ingestion, Time Frame: 0, 30, 60, 90, 120, 180, 240, 300 min postmeal | Secondary: Plasma glucose levels following meal ingestion, area under the plasma concentration versus time curve-AUC, 0, 30, 60, 90, 120, 180, 240, 300 min postmeal|Plasma insulin levels following meal ingestion, area under the plasma concentration versus time curve-AUC, 0, 30, 60, 90, 120, 180, 240, 300 min postmeal|Plasma triglyceride levels following meal ingestion, area under the plasma concentration versus time curve-AUC, 0, 30, 60, 90, 120, 180, 240, 300 min postmeal|Plasma total cholesterol levels following meal ingestion, area under the plasma concentration versus time curve-AUC, 0, 30, 60, 90, 120, 180, 240, 300 min postmeal|Plasma LDL-cholesterol levels following meal ingestion, area under the plasma concentration versus time curve-AUC, 0, 30, 60, 90, 120, 180, 240, 300 min postmeal|Plasma HDL-cholesterol levels following meal ingestion, area under the plasma concentration versus time curve-AUC, 0, 30, 60, 90, 120, 180, 240, 300 min postmeal|Plasma Apo-A levels following meal ingestion, area under the plasma concentration versus time curve-AUC, 0, 30, 60, 90, 120, 180, 240, 300 min postmeal|Plasma Apo-B levels following meal ingestion, area under the plasma concentration versus time curve-AUC, 0, 30, 60, 90, 120, 180, 240, 300 min postmeal|Plasma Lp(α) levels following meal ingestion, area under the plasma concentration versus time curve-AUC, 0, 30, 60, 90, 120, 180, 240, 300 min postmeal|Plasma NEFA levels following meal ingestion, area under the plasma concentration versus time curve-AUC, 0, 30, 60, 90, 120, 180, 240, 300 min postmeal|Plasma glycerol levels following meal ingestion, area under the plasma concentration versus time curve-AUC, 0, 30, 60, 90, 120, 180, 240, 300 min postmeal|Muscle blood flow following meal ingestion, area under the plasma concentration versus time curve-AUC, 0, 30, 60, 90, 120, 180, 240, 300 min postmeal|Plasma thyroid hormones, measure of plasma concentration, baseline|glucose uptake by peripheral monocytes by the usage of the fluorescent analogue 6-NBDG, area under the curve of 6-NBDG uptake by monocytes under insulin stimulation, baseline to 600 sec|% GLUT4 increment from baseline (0mU/l) to maximal concentration (200mU/l) of insulin., baseline|Number of participants with adverse events, 300 min postmeal
Sponsor/Collaborators: Sponsor: Attikon Hospital
Gender: ALL
Age: ADULT, OLDER_ADULT
Phases:
Enrollment: 33
Study Type: INTERVENTIONAL
Study Designs: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Start Date: 2009-02
Completion Date: 2015-07
Results First Posted:
Last Update Posted: 2015-07-28
Locations:
URL: https://clinicaltrials.gov/show/NCT02509858