| Trial ID: | L4323 |
| Source ID: | NCT01887119
|
| Associated Drug: |
Eplerenone
|
| Title: |
Aldosterone Antagonism and Microvascular Function
|
| Acronym: |
|
| Status: |
TERMINATED
|
| Study Results: |
NO
|
| Results: |
|
| Conditions: |
Abdominal Obesity Metabolic Syndrome|Insulin Resistance|Hypertension
|
| Interventions: |
DRUG: Eplerenone|OTHER: Placebo
|
| Outcome Measures: |
Primary: Change in capillary recruitment (insulin-induced increase in microvascular blood volume in skeletal muscle) from baseline after 4 weeks of Eplerenone treatment or placebo, The difference in microvascular blood volume in skeletal muscle of the forearm, which is assessed with contrast enhanced ultrasound, before and during a hyperinsulinemic, euglycemic clamp (performed to determine insulin sensitivity), Change from baseline after 4 weeks of treatment with either Eplerenone or placebo |
|
| Sponsor/Collaborators: |
Sponsor: Maastricht University Medical Center
|
| Gender: |
ALL
|
| Age: |
ADULT, OLDER_ADULT
|
| Phases: |
PHASE4
|
| Enrollment: |
25
|
| Study Type: |
INTERVENTIONAL
|
| Study Designs: |
Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
|
| Start Date: |
2013-10
|
| Completion Date: |
2018-11
|
| Results First Posted: |
|
| Last Update Posted: |
2018-11-05
|
| Locations: |
Maastricht University, Maastricht, Limburg, 6229 ER, Netherlands
|
| URL: |
https://clinicaltrials.gov/show/NCT01887119
|
