| Outcome Measures: |
Primary: difference in E/E' ratio between 12 weeks after baseline and at baseline, difference in E/E' ratio (noninvasive surrogate marker for left ventricular diastolic function (LVEDP) measured by 2D-echocardiography) between 12 weeks after baseline and at baseline, 12 weeks | Secondary: difference in E/E' ratio (change from baseline (V1) to 1 week follow-up), difference in E/E' ratio (change from baseline (V1) to 1 week follow-up (2D-echocardiography), 1 week|difference in Left ventricular systolic function (LVEF), difference in Left ventricular systolic function (LVEF) from baseline to week 1, 1 week|difference in Left ventricular systolic function (LVEF), difference in Left ventricular systolic function (LVEF) from baseline to week 12, 12 weeks|difference in Left end-diastolic volume (LEDV), difference in Left end-diastolic volume (LEDV) from baseline to week 1, 1 week|difference in Left end-diastolic volume (LEDV), difference in Left end-diastolic volume (LEDV) from baseline to week 12, 12 weeks|difference in Carotid-femoral pulse wave velocity, difference in Carotid-femoral pulse wave velocity (cf-PWV, vascular explorer - calculated) from baseline to week 1, 1 week|difference in Carotid-femoral pulse wave velocity, difference in Carotid-femoral pulse wave velocity (cf-PWV, vascular explorer - calculated) from baseline to week 12, 12 weeks|difference in Augmentation index (AIx), difference in Augmentation index (AIx, vascular explorer) from baseline to week 1, 1 week|difference in Augmentation index (AIx), difference in Augmentation index (AIx, vascular explorer) from baseline to week 12, 12 week|difference in Arterial stiffness index (SI), difference in Arterial stiffness index (SI, photo plethysmography) from baseline to week 1, 1 week|difference in Arterial stiffness index (SI), difference in Arterial stiffness index (SI, photo plethysmography) from baseline to week 12, 12 weeks|difference in Reflection index, difference in Reflection index (photo plethysmography) from baseline to week 1, 1 week|difference in Reflection index, difference in Reflection index (photo plethysmography) from baseline to week 12, 12 weeks|difference in Brain natriuretic peptide (BNP), difference in Brain natriuretic peptide (BNP) from baseline to week 1, 1 week|difference in Brain natriuretic peptide (BNP), difference in Brain natriuretic peptide (BNP) from baseline to week 12, 12 weeks|difference in High sensitive troponin I (hs TnI), difference in High sensitive troponin I (hs TnI) from baseline to week 1, 1 week|difference in High sensitive troponin I (hs TnI), difference in High sensitive troponin I (hs TnI) from baseline to week 12, 12 weeks|difference in High sensitive C-reactive protein (hs CRP), difference in High sensitive C-reactive protein (hs CRP) from baseline to week 1, 1 week|difference in High sensitive C-reactive protein (hs CRP), difference in High sensitive C-reactive protein (hs CRP) from baseline to week 12, 12 weeks|difference in E/E' ratio (change from baseline (V1) to 12 weeks follow-up) in the subgroup of patients with eGFR 45-59 ml/min/1.73 m², difference in E/E' ratio (noninvasive surrogate marker for left ventricular diastolic function (LVEDP) measured by 2D-echocardiography) between 12 weeks after baseline and at baseline in the subgroup of patients with eGFR 45-59 ml/min/1.73 m², 12 weeks|difference in E/E' ratio (change from baseline (V1) to 12 weeks follow-up) in the subgroup of patients with HbA1c 6.5%-6.9%, difference in E/E' ratio (noninvasive surrogate marker for left ventricular diastolic function (LVEDP) measured by 2D-echocardiography) between 12 weeks after baseline and at baseline in the subgroup of patients with with HbA1c 6.5%-6.9%, 12 weeks | Other: difference in biomarkers of cardiac diseases, changes between baseline and follow-up after 1 week in biomarkers of cardiac diseases, 1 week|difference in biomarkers of cardiac diseases, changes between baseline and follow-up after 12 weeks in biomarkers of cardiac diseases, 12 weeks|difference in biomarkers of vascular diseases, changes between baseline and follow-up after 1 week in biomarkers of vascular diseases, 1 week|difference in biomarkers of vascular diseases, changes between baseline and follow-up after 12 weeks in biomarkers of vascular diseases, 12 weeks|difference in biomarkers of metabolic/diabetic status, changes between baseline and follow-up after 1 week in biomarkers of metabolic/diabetic status, 1 week|difference in biomarkers of metabolic/diabetic status, changes between baseline and follow-up after 12 weeks in biomarkers of metabolic/diabetic status, 12 weeks|changes in vascular/endothelial function, changes between baseline and follow-up after 1 week in vascular/endothelial function, 1 week|changes in vascular/endothelial function, changes between baseline and follow-up after 12 weeks in vascular/endothelial function, 12 weeks|changes in carotid atherosclerosis, changes between baseline and follow-up after 1 week in carotid atherosclerosis, 1 week|changes in carotid atherosclerosis, changes between baseline and follow-up after 12 weeks in carotid atherosclerosis, 12 weeks|changes in pulmonary function, changes between baseline and follow-up after 1 week in pulmonary function, 1 week|changes in pulmonary function, changes between baseline and follow-up after 12 weeks in pulmonary function, 12 weeks|changes in ophthalmological diseases, changes between baseline and follow-up after 1 week in ophthalmological diseases, 1 week|changes in ophthalmological diseases, changes between baseline and follow-up after 12 weeks in ophthalmological diseases, 12 weeks|changes in psychosomatic diseases, changes between baseline and follow-up after 1 week in psychosomatic diseases, 1 week|changes in psychosomatic diseases, changes between baseline and follow-up after 12 weeks in psychosomatic diseases, 12 weeks|association analysis for selected SNPs, association analysis for selected SNPs (measured at baseline), baseline
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