| Outcome Measures: |
Primary: Changes from baseline following infusion of GLP-1RA (acute effects) and the changes from baseline following 12-week treatment with GLP-1RA or DPP-4i (long-term effects) on resting heart rate variability, as derived from electrocardiographic measurements., 12 weeks|Changes from baseline following infusion of GLP-1RA (acute effects) and the changes from baseline following 12-week treatment with GLP-1RA or DPP-4i (long-term effects) on Glomerular Filtration Rate, measured by the inulin-clearance technique., 12 weeks|Changes from baseline following 12-week treatment with GLP-1RA or DPP-4i (long-term effects) on pancreatic exocrine function, measured as fecal Elastase-1., 12 weeks | Secondary: Changes from baseline following infusion of GLP-1RA (acute effects) and the changes from baseline following 12-week treatment with GLP-1RA or DPP-4i (long-term effects) on the following cardiovascular parameters:, * Blood pressure and heart rate * Hemodynamic variables (blood pressure, heart rate, stroke volume, cardiac output/-index/-contractility, systemic vascular resistance) derived from non-invasive beat-to-beat finger blood pressure measurements * Cardiac autonomic nervous system function * Microvascular function and vasomotion * Arterial stiffness * Lipid spectrum * Glycemic variables (HbA1c, fasting and postprandial glucose) * Body anthropometrics: body weight, height, BMI and waist circumference * Body fat content, 12 weeks|Changes from baseline following infusion of GLP-1RA (acute effects) and the changes from baseline following 12-week treatment with GLP-1RA or DPP-4i (long-term effects) on the following renal parameters:, * Effective renal plasma flow (ERPF) * Renal tubular function * Renal damage, measured by urine biomarkers, 12 weeks|Changes from baseline following infusion of GLP-1RA (acute effects*) and changes from baseline following 12-week treatment with GLP-1RA or DPP-4i (long-term effects) on the following gastrointestinal parameters:, * Pancreatic exocrine function (\* In the acute intervention only exocrine pancreatic function is assessed) * Pancreatic structure * Pancreatic enzymes * Gallbladder emptying speed * Liver enzymes * Hepatic structure/steatosis * Gastric emptying, 12 weeks
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