| Outcome Measures: |
Primary: Percentage of patients with normal bone mineral density (z-score>-1)at lumbar spine(L2-L4)and total body after 12mo of supplementation, Bone mineral density will be assessed with DEXA (dual energy X ray absorptiometry)method at the beginning of the study and after 12 month of supplementation with vitamin D, 12 month|Percentage of patients with adequate 25 hydroxyvitamin level ( >50 ng/ml), every 3 month in spring summer autumn and winter each patient will have blood testing for the serum level of 25hydroxyvitamin D., 12 month|Mean bone mineral density z-score (L2-L4, total body) after 12 mo of supplementation, Bone mineral density will be assessed with DEXA (dual energy X ray absorptiometry)method at the beginning of the study and after 12 month of supplementation with vitamin D, 12 month|Mean isometric hand grip force, assessed at 6 and 12 mo of supplementation, 12 month | Secondary: Mean bone mineral density change after 12 mo of supplementation, 12 mo|Mean serum level of TNF-alfa, osteoprotegerin, IL-6, 12 mo|Mean HBA1C level, HBA1c level will be assessed at summer,spring,autumn and winter., 12 mo|% patients with HbA1C < 7,5 mg%, 12 mo|% patients with vitamin D hypervitaminosis (>200 ng/ml (500 nmol/L) and or hypercalcemia (>2.7 mmol/l) assessed at summer,spring, autumn, and winter, it will be assessed at summer,spring, autumn, and winter, 12 mo
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