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Clinical Trial Details

Trial ID: L4475
Source ID: NCT00039013
Associated Drug: Ac2993
Title: Evaluation of the Effect on Glucose Control of AC2993 in Patients With Type 2 Diabetes Mellitus Treated With Metformin
Acronym:
Status: COMPLETED
Study Results: NO
Results:
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: AC2993|DRUG: AC2993|DRUG: Placebo|DRUG: Placebo
Outcome Measures: Primary: Change in HbA1c (glycosylated hemoglobin) from baseline to study termination (Week 30), Change in HbA1c from from baseline, measured from Visit 3 (Day 1) to study termination (Week 30)., Baseline (Day 1), Week 30 | Secondary: Change in HbA1c from baseline (Day 1) to each of the intermediate visits, Change in HbA1c from baseline, measured from Visit 3 (Day 1) to each of the intermediate visits (Baseline (Day 1), Week 2, Week 4, Week, 6, Week 12, Week 18, and Week 24), Baseline (Day 1), Week 2, Week 4, Week, 6, Week 12, Week 18, Week 24|The number of subjects achieving HbA1c target values of < 7% and < 8% by Week 30, The number of subjects achieving HbA1c target values of \< 7% and \< 8% by study termination (Week 30), Baseline (Day 1) and Week 30|The number of subjects achieving HbA1c reductions of > 0.5% and > 1.0% by Week 30, The number of subjects achieving HbA1c reductions of \> 0.5% and \> 1.0% by study termination (Week 30), Baseline (Day 1), and Week 30|The time to achieve specific HbA1c target values of < 7% and < 8%, The time it takes subjects to achieve HbA1c target values of \< 7% and \< 8%, Baseline (Day 1), Week 2, Week 4, Week, 6, Week 12, Week 18, Week 24, Week 30|The time to achieve HbA1c reductions of 0.5% or more and >1.0% or more, The time it takes subjects to achieve HbA1c reductions of 0.5% or more and \>1.0% or more, Baseline (Day 1), Week 2, Week 4, Week, 6, Week 12, Week 18, Week 24, Week 30|Change in body weight from Baseline to each intermediate visit and Week 30, Change in body weight (kg) from Baseline to each intermediate visit and Week 30, Baseline (Day 1), Week 2, Week 4, Week, 6, Week 12, Week 18, Week 24, Week 30
Sponsor/Collaborators: Sponsor: AstraZeneca
Gender: ALL
Age: CHILD, ADULT, OLDER_ADULT
Phases: PHASE3
Enrollment: 336
Study Type: INTERVENTIONAL
Study Designs: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Start Date: 2002-03
Completion Date: 2003-06
Results First Posted:
Last Update Posted: 2015-02-24
Locations: Pinnacle Research Group, Anniston, Alabama, 36207, United States|Parkway Medical Center, Birmingham, Alabama, 35206, United States|Alabama Clinical Therapeutics, Birmingham, Alabama, 35235, United States|Eclectic Family Care, Eclectic, Alabama, 36024, United States|Winston Physician Services, Haleyville, Alabama, 35565, United States|Simon Williamson Clinic, Hueytown, Alabama, 35023, United States|Extended Arm Physicians/ Southern Drug, Montgomery, Alabama, 36106, United States|Southern Drug Research Network, Tallassee, Alabama, 36078, United States|Clinic of Physicians and Surgeons, Ltd., Mesa, Arizona, 85201, United States|ANA Ventures, LLC, Mesa, Arizona, 85204, United States|Lovelace Scientific Resources-Phoenix, Phoenix, Arizona, 85016, United States|Physicians at the Peak, Phoenix, Arizona, 85020, United States|Advanced Clinical Therapeutics, Tucson, Arizona, 85712, United States|CAVHS, Little Rock, Arkansas, 72205, United States|Physicians Group Research Clinic, LLC, Little Rock, Arkansas, 72205, United States|Advanced Clinical Research Institute, Anaheim, California, 92801, United States|Mitchell Research Group, Inc., Bakersfield, California, 93309, United States|William Zigrang, M.D., Burlingame, California, 94010, United States|International Clinical Research Network, Chula Vista, California, 91910, United States|Arrowhead Regional Medical Center, Colton, California, 92324, United States|Valley Research, Fresno, California, 93720, United States|Elke Jost-Vu, M.D., Rancho Mirage, California, 92270, United States|Comprehensive Diabetes-Endocrine Medical Associates, Redwood City, California, 94062, United States|nTouch, San Diego, California, 92103, United States|Radiant Research-San Diego, San Diego, California, 92108, United States|Veterans Medical Research Foundation, San Diego, California, 92161, United States|Diabetes Research Institute of Mills Peninsula, San Mateo, California, 94401, United States|Advanced Clinical Research Institute, Santa Ana, California, 92701, United States|West Coast Clinical Trials, Signal Hill, California, 90755, United States|Protocare Trials at Sharp Mission Park, Vista, California, 92083, United States|Diablo Clinical Research, Walnut Creek, California, 94598, United States|Medstar Clinical Research, Washington, District of Columbia, 20003-4393, United States|George Washington University, Washington, District of Columbia, 20037, United States|Internal Medical Associates, Ft. Myers, Florida, 33901, United States|Clin Sci International, Gainesville, Florida, 32605, United States|University of FL, Gainesville, Florida, 32610-0226, United States|Jupiter Research Institute, Jupiter, Florida, 33458, United States|Baptist Diabetes Associates, Miami, Florida, 33176, United States|Tampa Medical Group, Tampa, Florida, 33614, United States|Metabolic Research Institute, Inc., West Palm Beach, Florida, 33401, United States|Radiant Research, West Palm Beach, Florida, 33407, United States|nTouch Research Corporation, Decatur, Georgia, 30033, United States|East-West Medical Research Institute, Honolulu, Hawaii, 96813, United States|St. Luke's Family Health, Meridian, Idaho, 83642, United States|University Primary Care Center at Belvidere, Belvidere, Illinois, 61008, United States|Northwestern Memorial Physicians Group, Chicago, Illinois, 60602, United States|Illinois Center for Clinical Trials, Chicago, Illinois, 60610, United States|Lake Forest Internal Medicine, Libertyville, Illinois, 60048, United States|Winchester Research Group, Libertyville, Illinois, 60048, United States|Medical Group of Fort Wayne, Fort Wayne, Indiana, 46804, United States|American Health Network, Indianapolis, Indiana, 46222, United States|Center for Metabolic and Hormonal Disorders, Indianapolis, Indiana, 46260, United States|nTouch Research-South Bend, South Bend, Indiana, 46601, United States|Kentucky Diabetes Center, Lexington, Kentucky, 40503, United States|University of Kentucky Metabolic Research Group, Lexington, Kentucky, 40536-9841, United States|MedResearch, Inc., Louisville, Kentucky, 40223, United States|Drug Research Services, Metairie, Louisiana, 70001, United States|New Orleans Institute of Clinical Investigation, New Orleans, Louisiana, 70112, United States|Ochsner Clinic, New Orleans, Louisiana, 70121, United States|St. Agnes Health Care, Baltimore, Maryland, 21229, United States|Doctors Research Associates of Maryland, Lanham, Maryland, 20706, United States|Grunberger Diabetes Medical Center, Bloomfield Hills, Michigan, 48302, United States|Henry Ford Health System, Detroit, Michigan, 48202, United States|Grand Rapids Associated Interns, Grand Rapids, Michigan, 49506, United States|University of Mississippi Medical Center, Jackson, Mississippi, 39216, United States|Diabetes and Endocrinology Specialists, Chesterfield, Missouri, 63017, United States|Mid Missouri Research Specialists, Inc., Rolla, Missouri, 65401, United States|Radiant Research-St. Louis, St. Louis, Missouri, 63141, United States|Midwest Pharmaceutical Research, St. Peters, Missouri, 63376, United States|Mercury Street Medical, Butte, Montana, 59701, United States|Lovelace Scientific Resources-Las Vegas, Las Vegas, Nevada, 89102, United States|HIS Clinical Research, Jersey City, New Jersey, 07306, United States|Radiant Research-Moorestown, Moorestown, New Jersey, 08057, United States|New Jersey Physicians, Passaic, New Jersey, 07055, United States|Lovelace Scientific Resources, Albuquerque, New Mexico, 87108, United States|Medical Network Services, P.C., Brooklyn, New York, 11230, United States|St. Lukes Roosevelt Hospital, New York, New York, 10025, United States|Naomi Berrie Diabetes Center at Columbia University, New York, New York, 10032, United States|Heights Medical Care, New York, New York, 10033, United States|Rochester Clinical Research, Rochester, New York, 14609, United States|DOCS at Beth Israel Medical Center, Yonkers, New York, 10710, United States|Metrolina Medical Research, Charlotte, North Carolina, 28209, United States|Charlotte Clinical Research, Charlotte, North Carolina, 28211, United States|UNC Diabetes Care Center, Durham, North Carolina, 27713, United States|Unifour Medical Research, Hickory, North Carolina, 28601, United States|New Hanover Medical Research Associates, Wilmington, North Carolina, 28412, United States|Piedmont Medical Research, Winston-Salem, North Carolina, 27103, United States|Rapid Medical Research, Cleveland, Ohio, 44124, United States|Ohio State University-Division of Endocrinology, Columbus, Ohio, 43210, United States|Radiant Research-Columbus, Columbus, Ohio, 43212, United States|University Mednet, Mentor, Ohio, 44060, United States|COR Clinical Research, Oklahoma City, Oklahoma, 73103, United States|nTouch Research Corporation-Oklahoma City, Oklahoma City, Oklahoma, 73112, United States|Utica Park Clinic, Tulsa, Oklahoma, 74104, United States|Medford Medical Clinic, Medford, Oregon, 97504, United States|Legacy Clinical Research, Portland, Oregon, 97232, United States|Radiant Research, Portland, Oregon, United States|Physicians for Clinical Research, Camp Hill, Pennsylvania, 17011, United States|Thomas Jefferson University Diabetes Research Center, Philadelphia, Pennsylvania, 19107, United States|Philadelphia Health Associates, Philadelphia, Pennsylvania, 19146, United States|Tipton Medical and Diagnostic Center, Tipton, Pennsylvania, 16684, United States|Safe Harbor Clinical Research, East Providence, Rhode Island, 02914, United States|Radiant Research-Charleston, Charleston, South Carolina, 29407, United States|CNS Clinical Trials, Chester, South Carolina, 29706, United States|Coastal Carolina Research Center, Mt. Pleasant, South Carolina, 29464, United States|Integrity Clinical Research, Jackson, Tennessee, 38305, United States|Harmony Clinical Research, Johnson City, Tennessee, 37601, United States|Holston Medical Group, Kingsport, Tennessee, 37660, United States|Endocrine Consultants of ET, Knoxville, Tennessee, 37909, United States|Central Texas Clinical Research, Austin, Texas, 78705, United States|Rafael Canadas M.D., P.A., Dallas, Texas, 75251, United States|Texas Tech University Health Sciences-Internal Medicine, El Paso, Texas, 79905, United States|Internal Medicine Associates, El Paso, Texas, 79912, United States|North Texas Clinical Research, Irving, Texas, 75038, United States|Dr. Humberto Bruschetta, Kingsville, Texas, 78363, United States|South Texas Applied Research, McAllen, Texas, 78503, United States|University of Texas Health Sciences Center-Texas Diabetes Institute, San Antonio, Texas, 78207, United States|Diabetes and Glandular Disease Clinic, San Antonio, Texas, 78229-3894, United States|SAM Clinical Research Center, San Antonio, Texas, United States|Salt Lake Research, Salt Lake City, Utah, 84124, United States|Evergreen Diabetes & Endocrinology, Kirkland, Washington, 98034, United States|West Olympia Internal Medicine, Olympia, Washington, 98502, United States|Rainier Clinical Research Center, Renton, Washington, 98055, United States|Northside Internal Medicine, Spokane, Washington, 99201, United States|Rockwood Clinic, Spokane, Washington, 99202, United States|Julia M. Hutchinson, M.D., Spokane, Washington, 99204, United States|Wenatchee Valley Clinic, Wenatchee, Washington, 98801, United States|Hyperion Clinical Research, Charleston, West Virginia, 25301, United States|CAMC Clinical Trials Center, Charleston, West Virginia, 25304, United States
URL: https://clinicaltrials.gov/show/NCT00039013

Drug ID Drug Name Type DrugBank ID Targets Category Latest Progress