Clinical Trial Details
| Trial ID: | L0045 |
| Source ID: | NCT04702997 |
| Associated Drug: | Bardoxolone Methyl Oral Capsule |
| Title: | A Trial of Bardoxolone Methyl in Patients With CKD at Risk of Rapid Progression (MERLIN) |
| Acronym: | MERLIN |
| Status: | COMPLETED |
| Study Results: | YES |
| Results: | https://ClinicalTrials.gov/show/NCT04702997/results |
| Conditions: | Chronic Kidney Diseases |
| Interventions: | DRUG: Bardoxolone methyl oral capsule|DRUG: Placebo oral capsule |
| Outcome Measures: | Primary: Change From Baseline in Estimated Glomerular Filtration Rate (eGFR) at Week 12, To assess the change in eGFR from baseline to week 12. eGFR is a measure of kidney function assessed through blood/serum. Higher eGFRs represent better/improved kidney function. Lower eGFRs represent poorer/decreased kidney function., Baseline through 12 weeks after participant receives the first dose | |
| Sponsor/Collaborators: | Sponsor: Reata, a wholly owned subsidiary of Biogen |
| Gender: | ALL |
| Age: | ADULT, OLDER_ADULT |
| Phases: | PHASE2 |
| Enrollment: | 81 |
| Study Type: | INTERVENTIONAL |
| Study Designs: | Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT |
| Start Date: | 2021-02-09 |
| Completion Date: | 2021-11-23 |
| Results First Posted: | 2022-12-01 |
| Last Update Posted: | 2024-02-05 |
| Locations: | California Institute of Renal Research, La Mesa, California, 91942, United States|Western Nephrology, Arvada, Colorado, 80002, United States|Colorado Kidney Care, Denver, Colorado, 80230, United States|Boise Kidney & Hypertension, PLLC, Nampa, Idaho, 83687, United States|Renal Associates of Baton Rouge, Baton Rouge, Louisiana, 70808, United States|Nephrology Center, PC, Kalamazoo, Michigan, 49007, United States|DaVita Clinical Research, Las Vegas, Nevada, 89128, United States|Columbia Nephrology Associates, PA, Columbia, South Carolina, 29203, United States|Renal Disease Research Intitute, Dallas, Texas, 75235, United States|DaVita Clinical Research, Houston, Texas, 77004, United States|Gamma Medical Research Inc, McAllen, Texas, 78503, United States|Clinical Advancement Center, PLLC, San Antonio, Texas, 78212, United States |
| URL: | https://clinicaltrials.gov/show/NCT04702997 |
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress |
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