| Outcome Measures: |
Primary: Number of Participants With Adverse Events as a Measure of Safety and Tolerability, An adverse event is any untoward medical event that occurs in a participant administered an investigational product, and it does not necessarily indicate only events with clear causal relationship with the relevant investigational product., Up to Day 72 | Secondary: Maximum Observed Serum Concentration (Cmax), Maximum observed serum concentration (Cmax) of JNJ-64565111 will be assessed., First Dose: Predose (Day 1), and at 8, 24, 48, 72 and 120 hours post-dose (PD); Fourth Dose: predose (Day 22), and at 72, 96, 144, 168, 312, 480, 720, and 1200 hours PD.|Time to Reach Maximum Observed Plasma Concentration (Tmax), Actual sampling time to reach maximum observed serum concentration (Tmax) of JNJ-64565111 will be assessed., First Dose: Predose (Day 1), and at 8, 24, 48, 72 and 120 hours post-dose (PD); Fourth Dose: predose (Day 22), and at 72, 96, 144, 168, 312, 480, 720, and 1200 hours PD|Area Under Concentration-Time Curve From Time Zero to the Last Quantifiable Time (AUC [0-last]), The AUC (0-last) of JNJ-64565111 is the area under the serum concentration-time curve from time zero to last quantifiable time., First Dose: Predose (Day 1), and at 8, 24, 48, 72 and 120 hours post-dose (PD)|Average Concentration Over the Dosing Interval Tau (T) at Steady State (Caverage,ss), Average concentration over the dosing interval tau at steady state of JNJ-64565111 (defined as area under the serum concentration time curve observed during a dosing interval (tau) at steady state) will be calculated as AUC(0- T)/T., Fourth Dose: Predose (Day 22), and at 72, 96, 144, 168, 312, 480, 720, and 1200 hours PD|Minimum Observed Serum Concentration (Cmin), Minimum observed serum concentration (Cmin) of JNJ-64565111 will be assessed., Fourth Dose: Predose (Day 22), and at 72, 96, 144, 168, 312, 480, 720, and 1200 hours PD|Accumulation Ratio, Accumulation ratio of JNJ-64565111, calculated as AUC(0-T), Day 22 / AUC(0-T), Day 1 will be assessed after last dose., First Dose: Predose (Day 1), and at 8, 24, 48, 72 and 120 hours post-dose (PD); Fourth Dose: predose (Day 22), and at 72, 96, 144, 168 hours PD|Area Under Curve over the dosing interval AUC (0-T), The AUC (0-T) of JNJ-64565111 is the measure of the serum drug concentration from time zero to end of dosing interval. It is used to characterize drug absorption., Fourth Dose: Predose (Day 22), and at 72, 96, 144, 168 hours PD|Apparent Terminal Elimination Half-life (t1/2term), Apparent terminal elimination half-life of JNJ-64565111, calculated as 0.693/apparent terminal elimination rate constant (Lambda\[z\])., Fourth Dose: Predose (Day 22), and at 72, 96, 144, 168, 312, 480, 720, and 1200 hours PD|Apparent Clearance (CL/F), Clearance of a drug is a measure of the rate at which a drug is metabolized or eliminated by normal biological processes. Clearance obtained after subcutaneous (SC) dose (apparent SC clearance) is influenced by the fraction of the dose absorbed. Drug clearance is a quantitative measure of the rate at which a drug substance is removed from the blood. CL/F will be calculated as CL/F = Dose/AUC \[0-infinity\]., Fourth Dose: Predose (Day 22), and at 72, 96, 144, 168, 312, 480, 720, and 1200 hours PD|Apparent Volume of Distribution (V/F), Apparent volume of distribution of JNJ-64565111 is based on the terminal phase following subcutaneous administration calculated as Vd/F = Dose/ apparent terminal elimination rate constant (Lambda\[z\])\*AUC \[0-infinity\]., Fourth Dose: Predose (Day 22), and at 72, 96, 144, 168, 312, 480, 720, and 1200 hours PD|Terminal Rate Constant (Kel), Terminal rate constant of JNJ-64565111 is defined as the fraction of drug that is eliminated per unit of time (fraction/hour)., Fourth Dose: Predose (Day 22), and at 72, 96, 144, 168, 312, 480, 720, and 1200 hours PD|Number of Participants With Anti-JNJ-64565111 Antibodies as Measure of Immunogenicity, Immunogenicity will be measured by evaluating serum samples collected from participants. Serum samples will be screened for antibodies binding to JNJ-64565111. The titer of confirmed positive samples will be reported., First Dose: Predose (Day 1); Second Dose: predose (Day 8) Third Dose: predose (Day 15); Fourth Dose: predose (Day 22), 144, 480, 720, and 1200 hours post-dose.|Change From Baseline in Body Weight, Body weight will be measured using a calibrated scale at each time a participant is weighed. Calibration must be documented in a calibration log., Baseline, Days 8, 15, 22, 28, 29, 35, 42, 52, and 72|Change From Baseline in Fasting Plasma Glucose (FPG), Change from baseline in fasting plasma glucose (FPG) will be assessed., Baseline, Days 8, 15, 22, 28, 29, 35, 42, 52, and 72|Change From Baseline in Hemoglobin A1c (HbA1c), Change from baseline in HbA1c will be assessed., Baseline, Days 8, 15, 22, 28, 29, 35, 42, 52, and 72|Change From Baseline in Fasting Lipids, Fasting plasma lipids were measured to determine the total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), non-HDL cholesterol, very low-density lipoprotein cholesterol (VLDL-C), triglycerides and free fatty acids to understand the potential impact of study drug on cardiovascular disease risk., Baseline, Days 8, 15, 22, 28, 29, 35, 42, 52, and 72|Change From Baseline for 24-hour Mean Plasma Glucose, Mean plasma glucose defined as the total and/or incremental (that is, baseline-subtracted) area under the concentration (AUC) time curve over 0 to 24 hours, divided by 24., Baseline, Day 26|Change From Baseline in C-peptide Area Under the Curve (AUC) Calculated From a 6-Hour Mixed Meal Tolerance Test (MMTT), MMTT-Stimulated 6-Hour C-peptide AUC is the mean area under the C-peptide level-time curve over the 6-hour period divided by the duration after a mixed-meal tolerance test., Baseline, Day 26|Change From Baseline in Total and/or Incremental Plasma Glucose Area Under the Curve (AUC) Calculated From a 6-Hour Mixed Meal Tolerance Test (MMTT), MMTT-Stimulated 6-Hour total and/or incremental plasma glucose AUC is the mean area under the total and/or incremental plasma glucose level-time curve over the 6-hour period divided by the duration after a mixed-meal tolerance test., Baseline, Day 26|Change From Baseline in Insulin Area Under the Curve (AUC) Calculated From a 6-Hour Mixed Meal Tolerance Test (MMTT), MMTT-Stimulated 6-Hour Insulin AUC is the mean area under the insulin level-time curve over the 6-hour period divided by the duration after a mixed-meal tolerance test., Baseline, Day 26|Change From Baseline in Glucagon Area Under the Curve (AUC) Calculated From a 6-Hour Mixed Meal Tolerance Test (MMTT), MMTT-Stimulated 6-Hour Glucagon AUC is the mean area under the glucagon level-time curve over the 6-hour period divided by the duration after a mixed-meal tolerance test., Baseline, Day 26|Change From Baseline in 24-hour Blood Pressure, Blood Pressure will be assessed by 24-hour ambulatory blood pressure and heart rate monitoring (ABPM) device by periodic measurements performed at 1 hour intervals for the first 14 hours, then at 2-hour intervals for the remaining 10 hours (that is, 19 measurements in total)., Baseline and Day 28|Change From Baseline in 24-hour Heart Rate, Heart rate measurements will be assessed with a completely automated (ambulatory blood pressure and heart rate monitoring) device., Baseline and Day 28|Change From Baseline in Body Mass Index (BMI), Body Mass Index (BMI) is calculated by dividing the body weight (in kilogram) by the square of height (in meters)., Baseline, Days 8, 15, 22, 28, 29, 35, 42, 52, and 72|Change From Baseline Insulin Secretion as Assessed by the Insulinogenic Index, Insulin secretion will be assessed by the insulinogenic index (Insulin 30-Insulin 0)/(Glucose 30-Glucose 0), by measuring the ratio of insulin to glucose. The insulinogenic index is frequently used as a measure of beta cell function., Baseline, Day 26|Change from Baseline in Insulin Secretion as Assessed by Homeostasis Model Assessment of Beta Cell Function (HOMA-%B), HOMA is used to quantify insulin resistance and beta-cell function from basal (fasting) glucose and insulin (or C-peptide) concentrations. HOMA-B will be calculated by 20\*I/(G-3.5) where I is fasting plasma insulin (micro units/per milliliter \[uU/mL\]) and G is fasting plasma glucose (millimoles per liter \[mmol/L\])., Baseline, Day 26|Change From Baseline in Insulin Sensitivity as Assessed by Matsuda Index, The Matsuda index represents a composite of both hepatic and peripheral tissue sensitivity to insulin. Insulin sensitivity by Matsuda Index will be calculated by (10,000/square root of \[fasting glucose \* fasting insulin\] \* \[mean glucose \* mean insulin during oral glucose tolerance test \[OGTT\])., Baseline, Day 26|Change From Baseline in Insulin Sensitivity as Assessed by Homeostasis Model Assessment for Insulin Sensitivity (HOMA-%S), Insulin sensitivity will be assessed by Homeostasis Model Assessment (HOMA-%S) where HOMA-%S is 100/HOMA-Insulin Resistance \[IR\]. The HOMA-IR is the product of the blood Glucose and Insulin levels, divided by a constant. HOMA-IR is expressed as the following: HOMA-IR = fasting serum insulin (uU/mL) \* fasting plasma glucose (mmol/L) / 22.5., Baseline, Day 26
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