| Outcome Measures: |
Primary: HbA1c: Change From Baseline to 4 Month, AZD1656 is analyzed in a ANCOVA model (Glipized and Open Label is Not Included in the model), FAS Prior to Rescue, Baseline to 4th Month | Secondary: FPG: to Evaluate Change From Baseline to 4 Month, Compared With Placebo, FAS Prior to Rescue., AZD1656 is analyzed in a ANCOVA model (Glipized and Open Label is Not Included in the model), FAS Prior to Rescue., baseline to 4 month|SMPG: Change From Baseline to 4 Month, Compared With Placebo, FAS Prior to Rescue., AZD1656 is analyzed in a ANCOVA model (Glipized and Open Label is Not Included in the model), FAS Prior to Rescue., baseline to 4 month|OGTT/Plasma Glucose, The relative change in AUC, baseline to 4 month|OGTT/Insulin, The Relative Change in AUC FAS Prior to Rescue, baseline to 4 month|OGTT/C-peptide, The relative change, FAS prior to rescue, baseline to 4 month|OGTT/Pro-insulin/Insulin, The relative change, FAS prior to rescue, baseline to 4 month|HbA1c ≤ 7, Number of responders ≤ 7, FAS prior to rescue., baseline to 4 month|HbA1c ≤ 6.5, Number of Responders ≤ 6.5, FAS Prior to Rescue, baseline to 4 month|LDL-C: Mean Ratio, Geometric mean ratio (safety analysis set, regardless of rescue) and a 95 % CI., baseline to 4 month|HDL-C: Change From Baseline, Geometric mean ratio (safety analysis set, regardless of rescue) and a 95 % CI., baseline to 4 month|Total Cholesterol: Change From Baseline, Geometric mean ratio (safety analysis set, regardless of rescue) and a 95 % CI., baseline to 4 month|Triglycerides: Change From Baseline, Summary statistic of change from baseline, baseline to 4 month|C-reactive Protein: Change From Baseline, Geometric mean ratio (safety analysis set, regardless of rescue) and a 95 % CI, baseline to 4 month|Systolic Blood Pressure, Change From Baseline, Summary statistic of change from baseline, baseline to 4 month|Diastolic Blood Pressure, Change From Baseline, Summary statistic of change from baseline, baseline to 4 month|Pulse, Change From Baseline, Summary statistic of change from baseline, baseline to 4 month|Weight, Change From Baseline, Summary statistic of change from baseline, baseline to 4 month|QTcF; Electorcardiagram Change From Baseline, Summary statistic of change from baseline, baseline to 4 month|Haemoglobin; Change From Baseline, Summary statistic of change from baseline, baseline to 4 month|Leukocytes; Change From Baseline, Summary statistic of change from baseline, baseline to 4 month|Sodium; Change From Baseline, Summary statistic of change from baseline, baseline to 4 month|Potassium; Change From Baseline, Summary statistic of change from baseline, baseline to 4 month|Creatinine; Change From Baseline, Summary statistic of change from baseline, baseline to 4 month|ALT; Change From Baseline, Summary statistic of change from baseline, baseline to 4 month|AST; Change From Baseline, Summary statistic of change from baseline, baseline to 4 month|Alkaline Phosphatase; Change From Baseline, Summary statistic of change from baseline, baseline to 4 month|Bilirubin; Change From Baseline, Summary statistic of change from baseline, baseline to 4 month|CL/F to Characterise the PK Properties of AZD1656., The value is calculated using an allometric model (of a patient weighting 75 kg). The value is independent treatment given., at 4 month|EC50 to Characterise the PD Properties of AZD1656., The value is model based. The value is independent treatment given., at 4 month
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| Locations: |
Research Site, Temuco, Novena Region, Chile|Research Site, Brentwood, TN, Chile|Research Site, Santiago, Chile|Research Site, Temuco, Chile|Research Site, Dresden, SN, Germany|Research Site, Brentwood, TN, Germany|Research Site, Aschaffenburg, Germany|Research Site, Berlin, Germany|Research Site, Bochum, Germany|Research Site, Dortmund, Germany|Research Site, Frankfurt, Germany|Research Site, Görlitz, Germany|Research Site, Hamburg, Germany|Research Site, Lubeck, Germany|Research Site, Magdeburg, Germany|Research Site, St. Laurent, QC, Hungary|Research Site, Balatonfured, Hungary|Research Site, Bekescsaba, Hungary|Research Site, Dunaujvaros, Hungary|Research Site, Eger, Hungary|Research Site, Gyula, Hungary|Research Site, Kaposvar, Hungary|Research Site, Nyiregyhaza, Hungary|Research Site, Szekszard, Hungary|Research Site, Szigetvar, Hungary|Research Site, Zalaegerszeg, Hungary|Research Site, Brentwood, TN, Latvia|Research Site, Daugavpils, Latvia|Research Site, Jekabpils, Latvia|Research Site, Jelgava, Latvia|Research Site, Limbazi, Latvia|Research Site, Riga, Latvia|Research Site, Talsi, Latvia|Research Site, Valmiera, Latvia|Research Site, Brentwood, TN, Lithuania|Research Site, Kaunas, Lithuania|Research Site, Zapopan, Jalisco, Mexico|Research Site, Cuernavaca, Morelos, Mexico|Research Site, Monterrey, Nuevo Leon, Mexico|Research Site, Brentwood, TN, Mexico|Research Site, Meridas, Yucatan, Mexico|Research Site, Merida, Yucatan, Mexico|Research Site, Aguascalientes, Mexico|Research Site, Chiuahua, Mexico|Research Site, Monterrey, Mexico|Research Site, San Luis Potosi, Mexico|Research Site, Brentwood, TN, Peru|Research Site, Callao, Peru|Research Site, Lambayeque, Peru|Research Site, Lima, Peru|Research Site, Piura, Peru|Research Site, Trujillo, Peru|Research Site, Brentwood, TN, Poland|Research Site, Gdansk, Poland|Research Site, Krakow, Poland|Research Site, Kutno, Poland|Research Site, Wroclaw, Poland|Research Site, Alba Iulia, Alba, Romania|Research Site, Tg Mures, Mures, Romania|Research Site, Brentwood, TN, Romania|Research Site, Galati, Romania|Research Site, Ploiesti, Romania|Research Site, Sibiu, Romania|Research Site, Timisoara, Romania|Research Site, Brentwood, TN, Sweden|Research Site, Huddinge, Sweden|Research Site, Lund, Sweden|Research Site, Paignton, Devon, United Kingdom|Research Site, Liverpool, Merseyside, United Kingdom|Research Site, St. Laurent, QC, United Kingdom|Research Site, Cardiff, United Kingdom|Research Site, Chorley, United Kingdom|Research Site, Glasgow, United Kingdom|Research Site, Stevenage, United Kingdom|Research Site, West Bromwich, United Kingdom|Research Site, West Lothian, United Kingdom
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