| Outcome Measures: |
Primary: Cmax, Maximum Plasma Concentration, pre-dose and 0.25, 0.5, 1, 1.5, 2, 2.5, 3, 4, 6, 8, 10, 12, 18, and 24 hours post-dose.|(AUC0→∞), Area Under Curve Infinity, pre-dose and 0.25, 0.5, 1, 1.5, 2, 2.5, 3, 4, 6, 8, 10, 12, 18, and 24 hours post-dose.|(AUC0→t), Area Under the Curve, pre-dose and 0.25, 0.5, 1, 1.5, 2, 2.5, 3, 4, 6, 8, 10, 12, 18, and 24 hours post-dose.|tmax;, Time to reach Maximum concentration, pre-dose and 0.25, 0.5, 1, 1.5, 2, 2.5, 3, 4, 6, 8, 10, 12, 18, and 24 hours post-dose.|T½, Drug half Life, pre-dose and 0.25, 0.5, 1, 1.5, 2, 2.5, 3, 4, 6, 8, 10, 12, 18, and 24 hours post-dose.|Ke, Elimination Rate, pre-dose and 0.25, 0.5, 1, 1.5, 2, 2.5, 3, 4, 6, 8, 10, 12, 18, and 24 hours post-dose.|ka, Absorption Rate, pre-dose and 0.25, 0.5, 1, 1.5, 2, 2.5, 3, 4, 6, 8, 10, 12, 18, and 24 hours post-dose.|Blood Pressure, changes in Systolic and Diastolic Blood Pressure from normal range, measured before dosing and at 2, 4, 6, 8, and 10 hours after drug administration on each day of blood sampling|Heart Rate, Changes in heart rate from normal range, measured before dosing and at 2, 4, 6, 8, and 10 hours after drug administration on each day of blood sampling |
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