| Outcome Measures: |
Primary: Wound healing:Number of cells per clauster in tissue sample of wound., To evaluate the effect of supplementation in cellular differentiation. It will be counted and compared the number of cells per cluster in a tissue sample (lymphocytes, fibroblasts , macrophages and angiogeny) at the begining and after the supplementation., 15 days | Other: Bates- Jensen wound tool, To compared Bates- Jensen questionnaire will be applied two evaluations: first will be done before supplementation and second after finished the supplementation this scale consider physical characteristics of wound and give a punctuation 1 to 5 in each item ( size, depht, borders, necrosis, percentage of necrotic tissue , type of exudate, amount of exudate, skin color, edema, induration, granular tissue,epithelialization) according to this, items have a value that will be considered in a total punctuation of wound Punctuation 1-12 Health tissue 13- 59 regeneration 60. Degeneration, 15 days|Biochemical serum values of CPR, To evaluate and compared the values of serum CPR, two different serum samples ( at the beginning and after finished the supplementation), 15 days|Biochemical serum values of creatinine, To evaluate and compared the values of serum creatinine, two different serum samples ( at the beginning and after finished the supplementation), 15 days|Biochemical serum values of procalcitonine, To evaluate and compared the values of serum procalcitonine, two different serum samples ( at the beginning and after finished the supplementation), 15 days|Bacterial growth per clauster in culture wound, It will be taken a bacterial culture of wound in two different moments ( at the beginning and after finished the supplementation) Will be counted the colony number per clauster and type of bacteria., 15 days|Type of bacterial growth in wound, It will be taken a bacterial culture of wound in two different moments ( at the beginning and after finished the supplementation) will be counted the kind of bacteria., 15 days|Glucemic control by glucose, Glucose control will be messured in serum sample (mg/dL) in two different moments: at the begining and after finished the supplementation., 15 days|Glucemic control by HbA1c, HbA1c(%) control will be messured in serum in two different moments: at the begining and after finished the supplementation., 15 days|Incidence of treatment- adverse events, Each day of supplementation will be performed a questionary about subjective syntoms( as abdominal pain, diarrhea, nausea, vomiting, constipation or others) of supplementation,, 15 days
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