| Outcome Measures: |
Primary: Sleep energy expenditure, Change of sleep energy expenditure from baseline to Day 19 with SAR425899 or placebo, Baseline to Day 19 | Secondary: Total daily energy expenditure, Change of total energy expenditure from baseline to Day 19 with SAR425899 or placebo, Baseline to Day 19|Resting energy expenditure, Change of resting energy expenditure from baseline to Day 19 with SAR425899 or placebo, Baseline to Day 19|Basal energy expenditure, Change of basal energy expenditure from baseline to Day 19 with SAR425899 or placebo, Baseline to Day 19|Respiratory quotient (RQ), Change of respiratory quotient from baseline to Day 19 with SAR425899 or placebo, Baseline to Day 19|Fat mass and fat-free mass, Change of fat mass and fat-free mass by dual energy X-ray absorptiometry (DEXA) scan from baseline to Day 20 with SAR425899 or placebo, Baseline to Day 20|Diet Induced Thermogenesis (DIT), Change of DIT from baseline to Day 19 with SAR425899 or placebo, Baseline to Day 19|Fasting plasma glucose, Change of FPG over time with SAR425899 or placebo, 20 days|HbA1c, Change of HbA1c from baseline to Day 20 with SAR425899 or placebo, Baseline to Day 20|Lipid biomarker (free fatty acids, triglycerides, total cholesterol, HDL-/LDL-cholesterol), Change of lipid biomarkers over time with SAR425899 or placebo, 20 days|Ketone bodies, Change of ketone bodies over time with SAR425899 or placebo, 20 days|Adverse events, Number of adverse events in patients under treatment with SAR425899 or placebo, Up to 27 days|Pharmacokinetics, Assessment of SAR425899: time to reach Cmax (tmax), Day 16|Pharmacokinetics, Assessment of SAR425899: maximum plasma concentration (Cmax), Day 16|Pharmacokinetics, Assessment of SAR425899: area under the concentration versus time curve (AUC), Day 16|Pharmacokinetics, Assessment of SAR425899: terminal elimination half-life (t1/2), Day 16
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| Locations: |
Investigational Site Number 8400001, Orlando, Florida, 32804, United States|Investigational Site Number 8400002, Baton Rouge, Louisiana, 70808, United States
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