| Outcome Measures: |
Primary: Efficacy Measures Are Nerve Conduction Studies, Specifically Changes in Conduction Amplitude., 19 participants in each arm( placebo or omega-3-ethyl esters 4g) were analyzed . Conduction velocities and amplitude of the following nerves were compared between each arm: Tibial Nerve Ankle Amplitude, Tibial Nerve Popliteal Amplitude, Median Nerve Wrist Amplitude, Median Nerve Elbow Amplitude, Peroneal Motor Nerve Ankle Amplitude, Peroneal Motor Nerve Below Fibular Amplitude, Peroneal Motor Nerve Above Fibular Amplitude, Sensory Median Nerve Wrist Amplitude, Sensory Ulnar, Sensory Sural Ankle Ampltiude Wrist Ampltiude, One year|Measurements of Indices of Large and Small Fiber Nerve Function Including Heart Rate Variation Measures., Quantitative Autonomic Function Tests (QAFTs) were performed. Primarily, power spectral analysis of heart rate variability (HRV) and time- and frequency-domain analyses, including measures of the sympathetic and parasympathetic control of the heart beat (R-R interval), were recorded with deep breathing, Valsalva, and standing from the sitting position maneuvers. Additionally, the sample difference of the beat to beat (NN) intervals and the TSP was calculated as well as the standard deviation of all normal R-R intervals (sdNN)., One year|Measurements of Indices of Large and Small Fiber Nerve Function Using Vibration and Thermal Thresholds., Quantitative Sensory Tests (QSTs), including, cold sensation threshold, cold pain threshold and vibration detection threshold, were used to evaluate peripheral sensory perception., One year|Percent Change in Measurements of Indices of Large and Small Fiber Nerve Function Including Vibration Thresholds, Quantitative Sensory Tests (QSTs), including vibration detection threshold, were used to evaluate peripheral sensory perception. Mean represents percent change of total group. Measurements taken at baseline and at one year., One year|Measurements of Indices of Large and Small Fiber Nerve Function Including Markers of Inflammation and Oxidative Stress., Oxidative stress/inflammatory markers (IL1β, IKKβ, TLR4, TNF-α, JNK1, toll-like receptor 2) were assessed through a meal challenge., One year|Efficacy Measures Are Nerve Conduction Studies; Specifically, Increases in Conduction Velocity., One Year|Efficacy Measures Are Nerve Conduction Studies, Specifically Changes in Latency., One Year|Efficacy Measures Are Nerve Conduction Studies, Specifically Changes in F-wave Conduction, One Year|Efficacy Measures Examining Increased Vascular Response to Ischemic Block and to Local Warming at the Dorsum of the Foot., One Year |
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