| Trial ID: | L5147 |
| Source ID: | NCT01500590
|
| Associated Drug: |
Renin-Angiotensin System Blockers
|
| Title: |
Effect of Renin-angiotensin System Blockers on Glomerular Filtration Rate in Patients With Hypertension, Type 2 Diabetes With Normoalbuminuria
|
| Acronym: |
eGFR
|
| Status: |
UNKNOWN
|
| Study Results: |
NO
|
| Results: |
|
| Conditions: |
Diabetes|Hypertensive Disease
|
| Interventions: |
DRUG: Renin-angiotensin system blockers|DRUG: non-renin angiotensin system blockers
|
| Outcome Measures: |
Primary: change of estimated GFR calculated by MDRD equation and onset of microalbuminuria, Diabetes mellitus patients assigned to have RAS blockers have slower decline in GFR and delay in onset of microalbuminuria compared with those using other anti-hypertensive drugs. We measure the value of eGFR at baseline and every 6 months period in both control group and intervention group. The eGFR is calculated by MDRD equation. GFR = 186 x {serum creatinine (umol/l) /88.4}-1.154 x (age) -0.203 x ( 0.742 if female) We than calculate the difference of eGFR value every 6 month from the baseline. We would like to compare this difference in both groups., every 3 months |
|
| Sponsor/Collaborators: |
Sponsor: Hospital Authority, Hong Kong
|
| Gender: |
ALL
|
| Age: |
ADULT, OLDER_ADULT
|
| Phases: |
PHASE4
|
| Enrollment: |
1400
|
| Study Type: |
INTERVENTIONAL
|
| Study Designs: |
Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
|
| Start Date: |
2011-11
|
| Completion Date: |
2019-08
|
| Results First Posted: |
|
| Last Update Posted: |
2016-09-05
|
| Locations: |
Hospital Authority, HKEC, FM&PHC, Hong Kong, China
|
| URL: |
https://clinicaltrials.gov/show/NCT01500590
|
