| Outcome Measures: |
Primary: Improvement of quality of life, Mean change in 36-Item Short Form Health Survey, At week 24|Effect on MACE+ events, First occurence of major adverse cardiovascular + event (MACE+; all-cause mortality, myocardial infarction, stroke, and congestive heart failure requiring hospitalization) ., During 96 weeks | Secondary: Effect on blood transfusions, Difference in the proportion of patients receiving blood transfusions between high- and low-hemoglobin target groups, During 96 weeks|Effect on thromboembolic events, The variance in the risk of thromboembolic events (excluding those in the cardiovascular system of the heart and brain) between high- and low-hemoglobin target groups, During 96 weeks|Effect on MACE events, Dissimilarity in the risk of the first occurrence of MACE events between high- and low-hemoglobin target groups, During 96 weeks|Effect on cardiovascular death, Discrepancy in the risk of cardiovascular death between high- and low-hemoglobin target groups, During 96 weeks|Effect on renal events, Divergence in the incidence of renal events (defined as a reduction in eGFR by more than 50%, persistent dialysis for more than 3 months, or kidney transplantation) between high- and low-hemoglobin target groups, During 96 weeks|Effect on eGFR, Difference in the mean change of eGFR from baseline between high- and low-hemoglobin target groups, At weeks 24, 48, 72, and 96 | Other: Effect on the usage of iron agents, Difference in the usage of iron agents between high- and low-hemoglobin target groups, During 96 weeks|Effect on the indices of iron metabolism, Difference in the mean changes of ferritin, serum iron and transferrin saturation level from baseline between high- and low-hemoglobin target groups., at weeks 12, 24, 48, 72, and 96|Difference of dosage of enarodostat, Difference of mean dosage of enarodostat between high- and low-hemoglobin target groups, During 24 weeks|Evaluation of adverse drug events, The variance of adverse drug events between high- and low-hemoglobin target groups, during 96 weeks
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