| Trial ID: | L5348 |
| Source ID: | NCT00533559
|
| Associated Drug: |
Sodium Phenylbutyrate
|
| Title: |
Mechanism of Fatty Acid-induced Impairment of Glucose-simulated Insulin Secretion - Effect of Buphenyl
|
| Acronym: |
|
| Status: |
COMPLETED
|
| Study Results: |
NO
|
| Results: |
|
| Conditions: |
Diabetes|Insulin Resistance
|
| Interventions: |
DRUG: sodium phenylbutyrate|DRUG: Placebo
|
| Outcome Measures: |
Primary: we will measure insulin secretion, calculate disposition index and insulin clearance during a hyperglycemic clamp. We will also measure insulin sensitivity during a euglycemic hyperinsulinemic clamp, one year | Secondary: During the hyperglycemic clamp we will also measure Free Fatty Acid, C-peptide and triyglycerides. During the euglycemic hyperinsulinemic clamp we will determine the insulin sensitivity index and the disposition index., 1 year
|
| Sponsor/Collaborators: |
Sponsor: University Health Network, Toronto
|
| Gender: |
MALE
|
| Age: |
ADULT
|
| Phases: |
PHASE4
|
| Enrollment: |
10
|
| Study Type: |
INTERVENTIONAL
|
| Study Designs: |
Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
|
| Start Date: |
2007-09
|
| Completion Date: |
2010-03
|
| Results First Posted: |
|
| Last Update Posted: |
2010-06-25
|
| Locations: |
Toronto General Hospital, Toronto, Ontario, M5G 2C4, Canada
|
| URL: |
https://clinicaltrials.gov/show/NCT00533559
|
