| Outcome Measures: |
Primary: Change in Absolute Gluconeogenesis From Baseline to 12 Weeks, Gluconeogenesis is measured using stable isotope tracers and is reported as mg/kg lean body mass (LBM) per minute, Baseline to 12 weeks | Secondary: Change in Glucose Production Rate From Baseline to 12 Weeks, Glucose production rate is measured using stable isotope tracers and is reported as mg/kg LBM per minute., Baseline to 12 weeks|Change in GIP AUC During OGTT and Meal Absorption, Change in glucose-dependent insulinotropic polypeptide (GIP) AUC during OGTT and meal absorption, Baseline to 12 weeks|Change in GLP-1 Area Under the Curve Concentrations (AUC) During OGTT and Meal Absorption, Change in Glucagon-like peptide-1 (GLP-1) area under the curve concentrations (AUC) during OGTT and meal absorption. These data cannot be reported at this time due to problems with the assay. It is expected that a new assay will be available by May 2024, Baseline to 12 weeks|Change in Whole Body Insulin Sensitivity From Baseline to 12 Weeks, Whole body insulin sensitivity is estimated from a model of glucose and insulin values obtained during the OGTT and is measured in 10\^-4 mU/ml/min, Baseline to 12 weeks|Change in Hepatic Insulin Sensitivity Index From Baseline to 12 Weeks, The Hepatic Insulin Sensitivity Index(HISI) is the reciprocal of glucose rate of appearance \[1000/(μmol/min)\] X insulin concentration \[mU/L\], Baseline to 12 weeks|Change in Insulin AUC Concentrations During an OGTT and Meal Absorption, Change in insulin AUC as derived from 2-hour oral glucose tolerance test (OGTT). AUC is calculated using a trapezoidal rule. Higher AUC indicates higher insulin secretion, Baseline to 12 weeks|Change in Glycerol Turnover From Baseline to 12 Weeks, Glycerol turnover is measured using stable isotope tracers and is reported as mg/kg LBM per minute., Baseline to 12 weeks|Change in Palmitate Turnover From Baseline to 12 Weeks, Palmitate turnover is measured using stable isotope tracers and is reported as mg/kg LBM per minute., Baseline to 12 weeks
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