| Outcome Measures: |
Primary: CPT, current perception thresholds (CPT) at three frequencies (2000 Hz, 250 Hz, and 5 Hz) on both median and peroneal nerve, providing insight into large myelinated (2000Hz Aβ), medium-size myelinated (250Hz Aδ) and unmyelinated (5Hz C) small fibers function, baseline and week 4 | Secondary: Fructosamine, baseline and week 4|Fasting plasma glucose, baseline and week 4|BMI, body-mass index, baseline and week 4|SBP (standing), systolic blood pressure at standing position, baseline and week 4|eGFR, estimated glomerular flitration rate, baseline and week 4|MAU, urinary albumine concentration, baseline and week 4|RBC, red blood cell count, baseline and week 4|Hgb, hemoglobin, baseline and week 4|Htc, hematocrit, baseline and week 4|PLT, platelet count, baseline and week 4|Serum (m-Tyr+o-Tyr)/p-Tyr, Serum (meta-tyrosine + ortho-tyrosine)/para-tyrosine ratio, baseline and week 4|Urinary (m-Tyr+o-Tyr)/p-Tyr, Urinary (meta-tyrosine + ortho-tyrosine)/para-tyrosine ratio, baseline and week 4|Serum o-Tyr, Serum concentration of ortho-tyrosine, baseline and week 4|Serum o-Tyr/Phe, Serum ortho-tyrosine/phenilalanine ratio, baseline and week 4|Serum o-Tyr/p-Tyr, Serum ortho-tyrosine/para-tyrosine ratio, baseline and week 4
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