| Outcome Measures: |
Primary: angiotensin(1-7), Changes of serum angiotensin(1-7) at week 24 from baseline, 24 weeks | Secondary: Blood pressure, Change in blood pressure from baseline to week 24, 24 weeks|ACE-2, Changes of serum ACE-2 at week 24 from baseline, 24 weeks|Renin, Changes of serum renin at week 24 from baseline, 24 weeks|Aldosterone, Changes of serum aldosterone at week 24 from baseline, 24 weeks|hsCRP, Changes of serum hsCRP at week 24 from baseline, 24 weeks|HbA1c, Change in HbA1c from baseline to week 24, 24 weeks|glucose, Change in fasting glucose from baseline to week 24, 24 weeks|Insulin, Change in fasting insulin from baseline to week 24, 24 weeks|FMD, Change in flow mediated vasodilatation (FMD) from baseline to week 24, 24 weeks|Microcirculation, Change in microcirculation from baseline to week 24, 24 weeks|TG, Change in triglycerides from baseline to week 24, 24 weeks|HDL, Change in HDL cholesterol from baseline to week 24, 24 weeks|LDL, Change in LDL cholesterol from baseline to week 24, 24 weeks
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