| Outcome Measures: |
Primary: Peak concentration (Cmax), Maximum plasma drug concentration, Before administration, 0.5, 1, 2, 3, 4, 6, 8, 12, 24, 48, 72, 96, 120, 144, 168, 216, 264, 336 hours after administration|Area under drug time curve (AUC 0-t), Area under the plasma concentration time curve from time 0 to last time of quantifiable concentration, Before administration, 0.5, 1, 2, 3, 4, 6, 8, 12, 24, 48, 72, 96, 120, 144, 168, 216, 264, 336 hours after administration|Area under drug time curve (AUC 0-last), Area under the plasma concentration-time curve from time 0 extrapolated to infinite time, Before administration, 0.5, 1, 2, 3, 4, 6, 8, 12, 24, 48, 72, 96, 120, 144, 168, 216, 264, 336 hours after administration | Secondary: Incidence rate of adverse events, Record the number of cases, time of adverse events, including the abnormal changes in in physical examination, vital signs, 12 lead ECG, laboratory test values and other indicators., Before the first administration until it returns to normal or the level considered acceptable by the investigator
|
