| Trial ID: | L5667 |
| Source ID: | NCT01593137
|
| Associated Drug: |
Liraglutide + Metformin
|
| Title: |
A Long-term Trial to Compare the Effects of Liraglutide and Sulphonylurea (Glimepiride) Both in Combination With Metformin on Clinical, Endothelial and Image Markers of Cardiovascular Risk in Patients With Type 2 Diabetes
|
| Acronym: |
ADELANTE
|
| Status: |
WITHDRAWN
|
| Study Results: |
NO
|
| Results: |
|
| Conditions: |
Type 2 Diabetes
|
| Interventions: |
DRUG: Liraglutide + metformin|DRUG: Glimepiride + metformin
|
| Outcome Measures: |
Primary: assess the effect of treatment with liraglutide compared to glimepiride, as add-on to metformin, for one year on circulating levels of EPCs in patients with type 2 diabetes poorly controlled., 1 year | Secondary: assess the efficacy of liraglutide compared to glimepiride, as add-on to metformin, with regards to other surrogate biomarkers of cardiovascular risk: IMT, Central BP, CD40L, hsCRP, Lp-PLA2, BNP., 1 year|Relationship between EPC levels and all these biomarkers in patients treated with liraglutide compared to those treated with glimepiride., 1 year|Safety parameters of glycaemic control: HbA1c, FPG, 1 year
|
| Sponsor/Collaborators: |
Sponsor: Fundación Fernández-Cruz
|
| Gender: |
ALL
|
| Age: |
ADULT, OLDER_ADULT
|
| Phases: |
PHASE4
|
| Enrollment: |
0
|
| Study Type: |
INTERVENTIONAL
|
| Study Designs: |
Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
|
| Start Date: |
2012-05
|
| Completion Date: |
2014-12
|
| Results First Posted: |
|
| Last Update Posted: |
2013-07-02
|
| Locations: |
Hospital Clínico San Carlos, Madrid, 28040, Spain
|
| URL: |
https://clinicaltrials.gov/show/NCT01593137
|
