Logo 1 Logo 2

Clinical Trial Details

Trial ID: L5686
Source ID: NCT02451137
Associated Drug: Insulin Glargine, 300 U/Ml
Title: A "Real World" Trial to Determine Efficacy and Health Outcomes of Toujeo (ACHIEVE CONTROL REAL LIFE STUDY PROGRAM)
Acronym:
Status: COMPLETED
Study Results: YES
Results: https://ClinicalTrials.gov/show/NCT02451137/results
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Insulin glargine, 300 U/ml|DRUG: Insulin glargine, 100 U/ml|DRUG: Insulin detemir|DRUG: Background Therapy
Outcome Measures: Primary: Percentage of Participants With Individualized Glycated Hemoglobin Target Attainment Per Healthcare Effectiveness Data and Information Set (HEDIS) Criteria Without Documented Symptomatic(Blood Glucose <=70 mg/dL [<=3.9 mmol/L]) and/or Severe Hypoglycemia, HEDIS criteria: Individualized HbA1c target \<8% if age \>= 65 years or presence of medical comorbidities, or otherwise \<7%. Severe hypoglycaemia was an event in which the participant required the assistance of another person to actively administer carbohydrate, glucagon, or other resuscitative actions. Documented symptomatic hypoglycaemia was an event during which typical symptoms of hypoglycaemia were accompanied by a measured plasma glucose concentration of \<=70 milligrams per deciliter (mg/dL) (\<=3.9 millimoles per litre \[mmol/L\]). Analysis was performed using all post-baseline data available on the 6 month randomized period (defined as time from randomization up to Day 180 or discontinuation date, whichever comes earlier)., Baseline to Month 6 | Secondary: Change From Baseline in HbA1c at Month 6 and Month 12, Change in HbA1c was calculated by subtracting baseline value from Month 6 and Month 12 values. Adjusted Least Squares (LS) means and Standard Errors (SE) were obtained using Mixed Effect Model with Repeated Measures (MMRM ) with fixed categorical effects of treatment arm, visit, treatment arm-by-visit interaction, randomization strata of HbA1c target (\<8% / \<7%), SU use (yes/no), GLP-1 RA use (yes/no), as well as baseline HbA1c (as continuous) and baseline HbA1c-by-visit interaction., Baseline, Month 6, Month 12|Treatment Persistence Measured by Medication Possession Ratio (MPR), Treatment persistence was determined based on vendor claims database that would be responsible for managing and administration of the study drugs. Medication use was assessed by MPR and persistence measures based on data collected by the smart card vendor (date of fill or refill and quantity of medication dispensed for 30-day supply). The MPR was assessed based on total number of days of supply divided by the total number of days in 6 or 12 months period., At Month 6 and Month 12|Percentage of Participants Reaching Individualized HbA1c Target Without Documented Symptomatic <3.0 mmol/L (<54 mg/dL) and/or Severe Hypoglycemia During the 6-Month Randomized Period, HEDIS criteria for Individualized HbA1c target: \<8% if age \>= 65 years or presence of medical comorbidities, or otherwise \<7%. Severe hypoglycaemia was an event in which the participant required the assistance of another person to actively administer carbohydrate, glucagon, or other resuscitative actions. Documented symptomatic hypoglycaemia was an event during which typical symptoms of hypoglycaemia were accompanied by a measured plasma glucose concentration of \<54 mg/dL (3.0 mmol/L)., Baseline to Month 6|Percentage of Participants Reaching Individualized HbA1c Target Without Documented Symptomatic <=3.9 mmol/L (<= 70 mg/dL) and <3.0 mmol/L (< 54 mg/dL) and/or Severe Hypoglycemia During the 12-Month Randomized Period, HEDIS criteria for Individualized HbA1c target: \<8% if age \>= 65 years or presence of medical comorbidities, or otherwise \<7%. Severe hypoglycaemia was an event in which the participant required the assistance of another person to actively administer carbohydrate, glucagon, or other resuscitative actions. Documented symptomatic hypoglycaemia was an event during which typical symptoms of hypoglycaemia were accompanied by a measured plasma glucose concentration of \<=3.9 mmol/L (\<=70 mg/dL) and \< 3.0 mmol/L (\< 54 mg/dL)., Baseline to Month 12|Change From Baseline in Fasting Plasma Glucose (FPG) at Month 6 and Month 12, Change in FPG was calculated by subtracting baseline value from Month 6 and Month 12 values. Adjusted LS means and SE were obtained using MMRM model with fixed categorical effects of treatment arm, randomization strata of HbA1c target (\<8% / \<7%), SU use (yes/no), GLP-1 RA use (yes/no), as well as baseline FPG (as continuous) and baseline FPG-by-visit interaction., Baseline, Month 6, Month 12|Change From Baseline in Body Weight at Month 6 and Month 12, Adjusted LS means and SE were obtained using MMRM model with fixed categorical effects of treatment arm, visit, treatment arm-by-visit interaction, randomization strata of HbA1c target (\<8% / \<7%), SU use (yes/no), GLP-1 RA use (yes/no), as well as baseline weight (as continuous) and baseline weight-by-visit interaction., Baseline, Month 6, Month 12|Change From Baseline in Basal Insulin Dose at Month 6 and Month 12, Change in basal insulin dose was calculated by subtracting baseline value from Month 6 and Month 12 values., Baseline, Month 6, Month 12|Percentage of Responders (Participants and Provider) Who Reported "Excellent" or "Good" Responses to Global Effectiveness Scale (GES) Question at Month 6, and Month 12, Participant and Physician (Provider) reported GES for this diabetes study. The GES assessed impact of treatment on scale ranges as: excellent (complete control of diabetes), good (marked improvement of diabetes), moderate (discernible, but limited improvement in diabetes), poor (no appreciable change in diabetes), or worsening of condition (worsening of diabetes). There was no score expressed by numbers and no change measured over the time of the study. Percentage of participants and providers who reported "excellent" or "good" on the GES at Month 6 and Month 12 are reported here., At Month 6, Month 12|Scores of Total Treatment Satisfaction, Hyperglycemia Perception, and Hypoglycemia Perception From Diabetes Treatment Satisfaction Questionnaire Status Version (DTSQs) at Baseline, Month 6, Month 12, DTSQs is a validated questionnaire to assess participant's satisfaction with their diabetes treatment. It consists of 8 items, each answered on a Likert scale of 0 to 6. Responses of 6 questions (Items 1, 4, 5, 6, 7 and 8) were summarized to derive total treatment satisfaction score, such that a higher score was indicative of better satisfaction. Total treatment satisfaction score is the sum of items 1, 4-8 scores and ranged from 0 (no satisfaction) to 36 (improvement in treatment satisfaction). Item 2 and Item 3 scores were used for hyperglycemia perception and hypoglycemia perception respectively, where lower scores indicated better health outcome. Perceived frequency of hyperglycemia score (Item 2) and perceived frequency of hypoglycemia score (Item 3) range from 0 (none of the time) to 6 (most of time), where lower scores indicated more satisfaction/better health outcome., At Baseline, Month 6, Month 12|Scores of Total Treatment Satisfaction, Hyperglycemia Perception, and Hypoglycemia Perception From Diabetes Treatment Satisfaction Questionnaire Change Version (DTSQc) at Month 12, DTSQc version evaluates the change in treatment satisfaction at Month 12 as compared to the start of the study . It consists of 8 items, each answered on a Likert scale from -3 to +3. The sum of treatment satisfaction scores (items 1, 4, 5, 6, 7,and 8) ranged from score -18 (deterioration in treatment satisfaction) to +18 (improvement in treatment satisfaction). Perceived frequency of hypoglycemia and perceived frequency of hyperglycemia score ranges from score -3 (fewer problems) to +3 (more problems)., At Month 12|Percentage of Participants With Hospitalizations, Emergency Rooms and Specialty Visits From Baseline to Month 6 and Month 12, Percentage of participants with hospitalizations, emergency room visits, and specialty visits during the 6-month and 12-month randomized period were reported. The 12-month randomized period was defined as the time from randomization up to Day 365 or discontinuation date, whichever comes earlier., From Baseline to Month 6 and Month 12|Percentage of Participants With at Least One Treatment-Emergent Hypoglycemia Event (Any Time of the Day, Nocturnal) Per Type of Hypoglycaemia During the Month 6 and Month 12 on Treatment Period, Severe hypoglycaemia was an event in which the participant required the assistance of another person to actively administer carbohydrate, glucagon, or other resuscitative actions. Documented symptomatic hypoglycaemia was an event during which typical symptoms of hypoglycaemia were accompanied by a measured plasma glucose concentration of \<=70 mg/dL (\<=3.9 mmol/L) or \<54 mg/dL (3.0 mmol/L)., Up to Month 6 and Month 12
Sponsor/Collaborators: Sponsor: Sanofi
Gender: ALL
Age: ADULT, OLDER_ADULT
Phases: PHASE4
Enrollment: 3304
Study Type: INTERVENTIONAL
Study Designs: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Start Date: 2015-06-16
Completion Date: 2018-08-09
Results First Posted: 2019-05-01
Last Update Posted: 2019-09-10
Locations: Investigational Site Number 840731, Birmingham, Alabama, 35205, United States|Investigational Site Number 840305, Birmingham, Alabama, 35211, United States|Investigational Site Number 840811, Birmingham, Alabama, 35235, United States|Investigational Site Number 840218, Gulf Shores, Alabama, 36542, United States|Investigational Site Number 840739, Guntersville, Alabama, 35976, United States|Investigational Site Number 840367, Huntsville, Alabama, 35801, United States|Investigational Site Number 840130, Montgomery, Alabama, 36104, United States|Investigational Site Number 840729, Montgomery, Alabama, 36109, United States|Investigational Site Number 840281, Saraland, Alabama, 36571, United States|Investigational Site Number 840613, Sheffield, Alabama, 35660, United States|Investigational Site Number 840634, Sheffield, Alabama, 35660, United States|Investigational Site Number 840654, Sheffield, Alabama, 35660, United States|Investigational Site Number 840173, Phoenix, Arizona, 85032, United States|Investigational Site Number 840555, Phoenix, Arizona, 85037, United States|Investigational Site Number 840805, Sun City, Arizona, 85351, United States|Investigational Site Number 840725, Conway, Arkansas, 72034, United States|Investigational Site Number 840790, Jonesboro, Arkansas, 72401, United States|Investigational Site Number 840699, Little Rock, Arkansas, 72204, United States|Investigational Site Number 840528, Little Rock, Arkansas, 72205, United States|Investigational Site Number 840079, Searcy, Arkansas, 72143, United States|Investigational Site Number 840337, Bakersfield, California, 93304, United States|Investigational Site Number 840089, El Cajon, California, 92020, United States|Investigational Site Number 840024, Escondido, California, 92025, United States|Investigational Site Number 840020, Fresno, California, 93721, United States|Investigational Site Number 840470, Imperial, California, 92251, United States|Investigational Site Number 840155, Inglewood, California, 90301, United States|Investigational Site Number 840161, Inglewood, California, 90301, United States|Investigational Site Number 840194, Laguna Hills, California, 92653, United States|Investigational Site Number 840710, Laguna Hills, California, 92653, United States|Investigational Site Number 840204, Lancaster, California, 93534, United States|Investigational Site Number 840371, Los Angeles, California, 90017, United States|Investigational Site Number 840310, Los Angeles, California, 90036, United States|Investigational Site Number 840504, Los Angeles, California, 90036, United States|Investigational Site Number 840340, Los Angeles, California, 90057, United States|Investigational Site Number 840309, Los Gatos, California, 95032, United States|Investigational Site Number 840256, North Hollywood, California, 91606, United States|Investigational Site Number 840015, Northridge, California, 91325, United States|Investigational Site Number 840056, Norwalk, California, 90650, United States|Investigational Site Number 840090, Orange, California, 92868, United States|Investigational Site Number 840078, Palm Springs, California, 92262, United States|Investigational Site Number 840791, Palmdale, California, 93551, United States|Investigational Site Number 840216, Paramount, California, 90723, United States|Investigational Site Number 840413, Pomona, California, 91767, United States|Investigational Site Number 840244, Port Hueneme, California, 93041, United States|Investigational Site Number 840162, San Diego, California, 92111-6342, United States|Investigational Site Number 840028, San Diego, California, 92117-4961, United States|Investigational Site Number 840383, San Dimas, California, 91773, United States|Investigational Site Number 840627, San Jose, California, 95148, United States|Investigational Site Number 840120, San Ramon, California, 94583, United States|Investigational Site Number 840156, Santa Ana, California, 92704, United States|Investigational Site Number 840266, Sherman Oaks, California, 91403, United States|Investigational Site Number 840091, Sylmar, California, 91342, United States|Investigational Site Number 840208, Thousand Oaks, California, 91360, United States|Investigational Site Number 840115, Torrance, California, 90505, United States|Investigational Site Number 840792, Torrance, California, 90601, United States|Investigational Site Number 840612, Tulare, California, 93274, United States|Investigational Site Number 840467, Upland, California, 91786, United States|Investigational Site Number 840185, Vista, California, 92083, United States|Investigational Site Number 840472, Whittier, California, 90606, United States|Investigational Site Number 840411, Aurora, Colorado, 80014, United States|Investigational Site Number 840596, Denver, Colorado, 80209, United States|Investigational Site Number 840170, Denver, Colorado, 80246, United States|Investigational Site Number 840188, Englewood, Colorado, 80113, United States|Investigational Site Number 840329, Littleton, Colorado, 80127, United States|Investigational Site Number 840728, Littleton, Colorado, 80128, United States|Investigational Site Number 840687, Northglenn, Colorado, 80234, United States|Investigational Site Number 840643, Aventura, Florida, 33180, United States|Investigational Site Number 840652, Boca Raton, Florida, 33433, United States|Investigational Site Number 840449, Bradenton, Florida, 34209, United States|Investigational Site Number 840081, Cooper City, Florida, 33024, United States|Investigational Site Number 840027, Coral Gables, Florida, 33134, United States|Investigational Site Number 840446, Coral Gables, Florida, 33134, United States|Investigational Site Number 840407, Cutler Bay, Florida, 33157, United States|Investigational Site Number 840083, Doral, Florida, 33122, United States|Investigational Site Number 840141, Fleming Island, Florida, 32003, United States|Investigational Site Number 840035, Fort Lauderdale, Florida, 33316, United States|Investigational Site Number 840068, Fort Lauderdale, Florida, 33316, United States|Investigational Site Number 840145, Hialeah, Florida, 33016, United States|Investigational Site Number 840142, Jacksonville, Florida, 322078334, United States|Investigational Site Number 840352, Jacksonville, Florida, 32216, United States|Investigational Site Number 840021, Jupiter, Florida, 33458, United States|Investigational Site Number 840639, Kissimmee, Florida, 34741, United States|Investigational Site Number 840640, Kissimmee, Florida, 34741, United States|Investigational Site Number 840777, Lake Clarke Shores, Florida, 33406, United States|Investigational Site Number 840362, Margate, Florida, 33063, United States|Investigational Site Number 840221, Miami Lakes, Florida, 33016, United States|Investigational Site Number 840303, Miami Lakes, Florida, 33326, United States|Investigational Site Number 840002, Miami, Florida, 33015, United States|Investigational Site Number 840012, Miami, Florida, 33126, United States|Investigational Site Number 840698, Miami, Florida, 33126, United States|Investigational Site Number 840102, Miami, Florida, 33136, United States|Investigational Site Number 840209, Miami, Florida, 33142, United States|Investigational Site Number 840014, Miami, Florida, 33144, United States|Investigational Site Number 840128, Miami, Florida, 33155, United States|Investigational Site Number 840143, Miami, Florida, 33155, United States|Investigational Site Number 840349, Miami, Florida, 33155, United States|Investigational Site Number 840758, Miami, Florida, 33155, United States|Investigational Site Number 840690, Miami, Florida, 33166, United States|Investigational Site Number 840415, Miami, Florida, 33174, United States|Investigational Site Number 840197, Miami, Florida, 33185, United States|Investigational Site Number 840414, Miami, Florida, 33189, United States|Investigational Site Number 840508, Ocala, Florida, 34471, United States|Investigational Site Number 840092, Ocoee, Florida, 34761, United States|Investigational Site Number 840118, Palm Harbor, Florida, 34684, United States|Investigational Site Number 840080, Panama City, Florida, 32401, United States|Investigational Site Number 840372, Plantation, Florida, 33313, United States|Investigational Site Number 840199, Port Charlotte, Florida, 33952, United States|Investigational Site Number 840538, Winter Haven, Florida, 33880, United States|Investigational Site Number 840261, Atlanta, Georgia, 30328, United States|Investigational Site Number 840232, Atlanta, Georgia, 30342, United States|Investigational Site Number 840129, Blue Ridge, Georgia, 30513, United States|Investigational Site Number 840820, Columbus, Georgia, 31904, United States|Investigational Site Number 840767, Decatur, Georgia, 30034, United States|Investigational Site Number 840812, Decatur, Georgia, 30035, United States|Investigational Site Number 840700, Dunwoody, Georgia, 30338, United States|Investigational Site Number 840648, East Point, Georgia, 30344, United States|Investigational Site Number 840110, Lawrenceville, Georgia, United States|Investigational Site Number 840444, Macon, Georgia, 31210, United States|Investigational Site Number 840003, Marietta, Georgia, 30067, United States|Investigational Site Number 840632, Sandersville, Georgia, 31082, United States|Investigational Site Number 840616, Savannah, Georgia, 31404, United States|Investigational Site Number 840591, Savannah, Georgia, 31406, United States|Investigational Site Number 840727, Smyrna, Georgia, 30082, United States|Investigational Site Number 840520, Snellville, Georgia, 30078, United States|Investigational Site Number 840163, Statesboro, Georgia, 30461, United States|Investigational Site Number 840297, Stockbridge, Georgia, 30281, United States|Investigational Site Number 840715, Thomson, Georgia, 30824, United States|Investigational Site Number 840400, Blackfoot, Idaho, 83221, United States|Investigational Site Number 840764, Boise, Idaho, 83642, United States|Investigational Site Number 840005, Chicago, Illinois, 60607, United States|Investigational Site Number 840399, Chicago, Illinois, 60607, United States|Investigational Site Number 840301, Elgin, Illinois, 60124, United States|Investigational Site Number 840402, Joliet, Illinois, 60435, United States|Investigational Site Number 840226, Morton, Illinois, 61550, United States|Investigational Site Number 840318, Peoria, Illinois, 61602, United States|Investigational Site Number 840125, Avon, Indiana, 46123, United States|Investigational Site Number 840344, Brownsburg, Indiana, 46112, United States|Investigational Site Number 840007, Evansville, Indiana, 47714, United States|Investigational Site Number 840164, Evansville, Indiana, 47714, United States|Investigational Site Number 840324, Evansville, Indiana, 47715, United States|Investigational Site Number 840022, Franklin, Indiana, 46131, United States|Investigational Site Number 840536, Greenfield, Indiana, 46140, United States|Investigational Site Number 840582, Indianapolis, Indiana, 46254, United States|Investigational Site Number 840694, Michigan City, Indiana, 46360, United States|Investigational Site Number 840052, Muncie, Indiana, 47304, United States|Investigational Site Number 840786, New Albany, Indiana, 47150, United States|Investigational Site Number 840686, Council Bluffs, Iowa, 51501, United States|Investigational Site Number 840175, Des Moines, Iowa, 50134, United States|Investigational Site Number 840466, West Des Moines, Iowa, 50266, United States|Investigational Site Number 840134, Topeka, Kansas, 66606, United States|Investigational Site Number 840801, Ashland, Kentucky, 41101, United States|Investigational Site Number 840754, Benton, Kentucky, 42025, United States|Investigational Site Number 840342, Covington, Kentucky, 41011, United States|Investigational Site Number 840713, Elizabethtown, Kentucky, 42701, United States|Investigational Site Number 840681, Hopkinsville, Kentucky, 42240, United States|Investigational Site Number 840578, Louisville, Kentucky, 40202, United States|Investigational Site Number 840478, Owensboro, Kentucky, 42303, United States|Investigational Site Number 840576, Owensboro, Kentucky, 42303, United States|Investigational Site Number 840819, Owensboro, Kentucky, 42320, United States|Investigational Site Number 840645, Paris, Kentucky, 40361, United States|Investigational Site Number 840741, Versailles, Kentucky, 40383, United States|Investigational Site Number 840592, Covington, Louisiana, 70433, United States|Investigational Site Number 840744, Covington, Louisiana, 70433, United States|Investigational Site Number 840532, Crowley, Louisiana, 70526, United States|Investigational Site Number 840760, Hammond, Louisiana, 70403, United States|Investigational Site Number 840463, Lake Charles, Louisiana, 70601, United States|Investigational Site Number 840675, Marrero, Louisiana, 70072, United States|Investigational Site Number 840133, Metairie, Louisiana, 70006, United States|Investigational Site Number 840622, Monroe, Louisiana, 71203, United States|Investigational Site Number 840147, Natchitoches, Louisiana, 71457, United States|Investigational Site Number 840609, New Orleans, Louisiana, 70115, United States|Investigational Site Number 840311, Shreveport, Louisiana, 71105, United States|Investigational Site Number 840619, Slidell, Louisiana, 70458, United States|Investigational Site Number 840673, Zachary, Louisiana, 70791, United States|Investigational Site Number 840387, Bangor, Maine, 04401, United States|Investigational Site Number 840689, Portland, Maine, 04101, United States|Investigational Site Number 840534, Baltimore, Maryland, 21218, United States|Investigational Site Number 840455, Catonsville, Maryland, 21228, United States|Investigational Site Number 840393, Rockville, Maryland, 20852, United States|Investigational Site Number 840423, Boston, Massachusetts, 02115, United States|Investigational Site Number 840117, Alpena, Michigan, 49707, United States|Investigational Site Number 840289, Detroit, Michigan, 48235, United States|Investigational Site Number 840053, Essexville, Michigan, 48732, United States|Investigational Site Number 840150, Flint, Michigan, 48504, United States|Investigational Site Number 840184, Flint, Michigan, 48532, United States|Investigational Site Number 840236, Kalamazoo, Michigan, 49009, United States|Investigational Site Number 840210, Southfield, Michigan, United States|Investigational Site Number 840258, Stevensville, Michigan, 49127, United States|Investigational Site Number 840158, Troy, Michigan, 48085, United States|Investigational Site Number 840524, Troy, Michigan, 48098, United States|Investigational Site Number 840033, Olive Branch, Mississippi, 38654, United States|Investigational Site Number 840302, Bridgeton, Missouri, 63044, United States|Investigational Site Number 840693, Chesterfield, Missouri, 63017, United States|Investigational Site Number 840041, Jefferson City, Missouri, 65109, United States|Investigational Site Number 840711, Saint Louis, Missouri, 63128, United States|Investigational Site Number 840753, Billings, Montana, 59102, United States|Investigational Site Number 840603, Butte, Montana, 59701, United States|Investigational Site Number 840264, Elkhorn, Nebraska, 68022, United States|Investigational Site Number 840742, Omaha, Nebraska, 68144, United States|Investigational Site Number 840294, Henderson, Nevada, 89014, United States|Investigational Site Number 840087, Henderson, Nevada, 89052, United States|Investigational Site Number 840664, Las Vegas, Nevada, 89101, United States|Investigational Site Number 840108, Las Vegas, Nevada, 89106, United States|Investigational Site Number 840412, Las Vegas, Nevada, 89109, United States|Investigational Site Number 840656, Las Vegas, Nevada, 89117, United States|Investigational Site Number 840638, Las Vegas, Nevada, 89118, United States|Investigational Site Number 840750, Las Vegas, Nevada, 89121, United States|Investigational Site Number 840815, Las Vegas, Nevada, 89144, United States|Investigational Site Number 840761, Reno, Nevada, 89511, United States|Investigational Site Number 840144, Nashua, New Hampshire, 03063-4068, United States|Investigational Site Number 840799, Edison, New Jersey, 08837, United States|Investigational Site Number 840167, Linden, New Jersey, 07036, United States|Investigational Site Number 840060, Neptune, New Jersey, 07753, United States|Investigational Site Number 840679, Sicklerville, New Jersey, 08081, United States|Investigational Site Number 840559, Teaneck, New Jersey, 07666, United States|Investigational Site Number 840481, Albany, New York, 12206, United States|Investigational Site Number 840772, Amityville, New York, 11701, United States|Investigational Site Number 840746, Babylon, New York, 11702, United States|Investigational Site Number 840355, Brooklyn, New York, 11215, United States|Investigational Site Number 840136, Brooklyn, New York, United States|Investigational Site Number 840734, Forest Hills, New York, 11375, United States|Investigational Site Number 840659, Great Neck, New York, 11367, United States|Investigational Site Number 840644, Holbrook, New York, 11741, United States|Investigational Site Number 840159, Jamaica, New York, 11432, United States|Investigational Site Number 840148, Lake Success, New York, 11042, United States|Investigational Site Number 840253, Laurelton, New York, 11422, United States|Investigational Site Number 840789, Merrick, New York, 11566, United States|Investigational Site Number 840716, Nesconset, New York, 11767, United States|Investigational Site Number 840810, New Hyde Park, New York, 11040, United States|Investigational Site Number 840072, New Hyde Park, New York, 11042, United States|Investigational Site Number 840674, New Windsor, New York, 12553, United States|Investigational Site Number 840626, New York, New York, 10001, United States|Investigational Site Number 840586, New York, New York, 10128, United States|Investigational Site Number 840044, North Massapequa, New York, 11758-1802, United States|Investigational Site Number 840587, Smithtown, New York, 11787, United States|Investigational Site Number 840577, Staten Island, New York, 10301-3914, United States|Investigational Site Number 840773, Syosset, New York, 11791, United States|Investigational Site Number 840047, Yonkers, New York, 10704, United States|Investigational Site Number 840214, Asheville, North Carolina, 28803, United States|Investigational Site Number 840237, Burlington, North Carolina, 27215, United States|Investigational Site Number 840714, Burlington, North Carolina, 27215, United States|Investigational Site Number 840456, Charlotte, North Carolina, 28204, United States|Investigational Site Number 840312, Concord, North Carolina, 28025, United States|Investigational Site Number 840763, Greensboro, North Carolina, 27401, United States|Investigational Site Number 840611, Greensboro, North Carolina, 27405, United States|Investigational Site Number 840776, Greensboro, North Carolina, 27408, United States|Investigational Site Number 840361, Greenville, North Carolina, 27834, United States|Investigational Site Number 840705, High Point, North Carolina, 27262, United States|Investigational Site Number 840755, Lexington, North Carolina, 27292, United States|Investigational Site Number 840688, Mooresville, North Carolina, 28117, United States|Investigational Site Number 840747, Mooresville, North Carolina, 28117, United States|Investigational Site Number 840296, Morganton, North Carolina, 28655, United States|Investigational Site Number 840573, New Bern, North Carolina, 28562, United States|Investigational Site Number 840096, Salisbury, North Carolina, 28144, United States|Investigational Site Number 840697, Shelby, North Carolina, 28150, United States|Investigational Site Number 840636, Wilmington, North Carolina, 28401, United States|Investigational Site Number 840195, Wilson, North Carolina, 27893, United States|Investigational Site Number 840315, Winston-Salem, North Carolina, 27103, United States|Investigational Site Number 840545, Fargo, North Dakota, 58104, United States|Investigational Site Number 840077, Canal Fulton, Ohio, 44614, United States|Investigational Site Number 840738, Canton, Ohio, 44718, United States|Investigational Site Number 840064, Cincinnati, Ohio, 45212, United States|Investigational Site Number 840701, Cincinnati, Ohio, 45242, United States|Investigational Site Number 840779, Cleveland, Ohio, 44113, United States|Investigational Site Number 840380, Columbus, Ohio, 43201, United States|Investigational Site Number 840339, Columbus, Ohio, 43203, United States|Investigational Site Number 840063, Columbus, Ohio, 43207, United States|Investigational Site Number 840191, Columbus, Ohio, 43207, United States|Investigational Site Number 840752, Columbus, Ohio, 43213, United States|Investigational Site Number 840684, Elyria, Ohio, 44035, United States|Investigational Site Number 840663, Findlay, Ohio, 45840, United States|Investigational Site Number 840379, Franklin, Ohio, 45005, United States|Investigational Site Number 840126, Gallipolis, Ohio, 45631, United States|Investigational Site Number 840771, Kettering, Ohio, 45429, United States|Investigational Site Number 840257, Lancaster, Ohio, 43130, United States|Investigational Site Number 840584, Lyndhurst, Ohio, 44124, United States|Investigational Site Number 840165, Marion, Ohio, 43302, United States|Investigational Site Number 840800, Miamisburg, Ohio, 45342, United States|Investigational Site Number 840560, Tallmadge, Ohio, 44278, United States|Investigational Site Number 840515, Toledo, Ohio, 43623, United States|Investigational Site Number 840797, Vandalia, Ohio, 45377, United States|Investigational Site Number 840192, Wadsworth, Ohio, 44201, United States|Investigational Site Number 840389, Willoughby Hills, Ohio, 44094, United States|Investigational Site Number 840751, Wooster, Ohio, 44691, United States|Investigational Site Number 840262, Edmond, Oklahoma, 73034, United States|Investigational Site Number 840360, Midwest City, Oklahoma, 73110, United States|Investigational Site Number 840363, Oklahoma City, Oklahoma, 73104, United States|Investigational Site Number 840556, Oklahoma City, Oklahoma, 73112, United States|Investigational Site Number 840103, Bend, Oregon, 97702, United States|Investigational Site Number 840292, Altoona, Pennsylvania, 16602, United States|Investigational Site Number 840009, Beaver, Pennsylvania, 15009, United States|Investigational Site Number 840059, Downingtown, Pennsylvania, 19335, United States|Investigational Site Number 840181, Fleetwood, Pennsylvania, 19522, United States|Investigational Site Number 840743, Greensburg, Pennsylvania, 15601, United States|Investigational Site Number 840479, Huntingdon Valley, Pennsylvania, 19006, United States|Investigational Site Number 840712, Indiana, Pennsylvania, 15701, United States|Investigational Site Number 840523, Lansdale, Pennsylvania, 19446, United States|Investigational Site Number 840766, Levittown, Pennsylvania, 19056, United States|Investigational Site Number 840032, Penndel, Pennsylvania, 19047, United States|Investigational Site Number 840067, Philadelphia, Pennsylvania, 19102, United States|Investigational Site Number 840277, Philadelphia, Pennsylvania, 19107, United States|Investigational Site Number 840561, Philadelphia, Pennsylvania, 19114, United States|Investigational Site Number 840174, Philadelphia, Pennsylvania, 19146, United States|Investigational Site Number 840348, Pittsburgh, Pennsylvania, 15243, United States|Investigational Site Number 840669, Pottstown, Pennsylvania, 19464, United States|Investigational Site Number 840748, Sayre, Pennsylvania, 18840, United States|Investigational Site Number 840187, Smithfield, Pennsylvania, 15478, United States|Investigational Site Number 840287, Uniontown, Pennsylvania, 15401, United States|Investigational Site Number 840341, Uniontown, Pennsylvania, 15401, United States|Investigational Site Number 840378, Providence, Rhode Island, 02908, United States|Investigational Site Number 840491, Anderson, South Carolina, 29621, United States|Investigational Site Number 840732, Greenville, South Carolina, 29601, United States|Investigational Site Number 840043, Greer, South Carolina, 29651, United States|Investigational Site Number 840109, Murrells Inlet, South Carolina, 29576, United States|Investigational Site Number 840327, North Myrtle Beach, South Carolina, 29582, United States|Investigational Site Number 840759, Simpsonville, South Carolina, 29681, United States|Investigational Site Number 840628, Summerville, South Carolina, 29485, United States|Investigational Site Number 840717, Bristol, Tennessee, 37620, United States|Investigational Site Number 840160, Chattanooga, Tennessee, 37404, United States|Investigational Site Number 840794, Franklin, Tennessee, 37064, United States|Investigational Site Number 840171, Jackson, Tennessee, 38305, United States|Investigational Site Number 840550, Jackson, Tennessee, 38305, United States|Investigational Site Number 840132, Kingsport, Tennessee, 37660, United States|Investigational Site Number 840140, Knoxville, Tennessee, 37912, United States|Investigational Site Number 840625, Memphis, Tennessee, 38119, United States|Investigational Site Number 840299, Nashville, Tennessee, 37203, United States|Investigational Site Number 840381, New Tazewell, Tennessee, 37825, United States|Investigational Site Number 840213, Amarillo, Texas, 79106, United States|Investigational Site Number 840157, Corpus Christi, Texas, 78404, United States|Investigational Site Number 840011, Dallas, Texas, 75218, United States|Investigational Site Number 840313, Dallas, Texas, 75218, United States|Investigational Site Number 840013, Dallas, Texas, 75231, United States|Investigational Site Number 840034, Dallas, Texas, 75231, United States|Investigational Site Number 840333, Dallas, Texas, 75235, United States|Investigational Site Number 840405, Dallas, Texas, 75254, United States|Investigational Site Number 840330, El Paso, Texas, 79925, United States|Investigational Site Number 840307, Fort Worth, Texas, 76104, United States|Investigational Site Number 840182, Houston, Texas, 77008, United States|Investigational Site Number 840366, Houston, Texas, 77024, United States|Investigational Site Number 840608, Houston, Texas, 77043, United States|Investigational Site Number 840323, Houston, Texas, 77053, United States|Investigational Site Number 840502, Houston, Texas, 77070, United States|Investigational Site Number 840513, Houston, Texas, 77070, United States|Investigational Site Number 840377, Houston, Texas, 77079, United States|Investigational Site Number 840306, Houston, Texas, 77083-4436, United States|Investigational Site Number 840137, Houston, Texas, 77090, United States|Investigational Site Number 840521, Houston, Texas, 77090, United States|Investigational Site Number 840533, Houston, Texas, 77095, United States|Investigational Site Number 840211, Houston, Texas, 77099, United States|Investigational Site Number 840260, Humble, Texas, 77338, United States|Investigational Site Number 840403, Irving, Texas, 75039, United States|Investigational Site Number 840382, Lampasas, Texas, 76550, United States|Investigational Site Number 840680, Lubbock, Texas, 79423, United States|Investigational Site Number 840308, McAllen, Texas, 78503, United States|Investigational Site Number 840549, Mesquite, Texas, 75149, United States|Investigational Site Number 840351, Missouri City, Texas, 77459, United States|Investigational Site Number 840373, Palestine, Texas, 75801, United States|Investigational Site Number 840365, Pharr, Texas, 78577, United States|Investigational Site Number 840439, Plano, Texas, 75093, United States|Investigational Site Number 840707, Port Arthur, Texas, 77640, United States|Investigational Site Number 840692, Richmond, Texas, 77469, United States|Investigational Site Number 840431, San Antonio, Texas, 78215, United States|Investigational Site Number 840074, San Antonio, Texas, 78218, United States|Investigational Site Number 840691, San Antonio, Texas, 78221, United States|Investigational Site Number 840176, San Antonio, Texas, 78228, United States|Investigational Site Number 840135, San Antonio, Texas, 78229-3901, United States|Investigational Site Number 840018, San Antonio, Texas, 78229, United States|Investigational Site Number 840434, San Antonio, Texas, 78229, United States|Investigational Site Number 840390, San Antonio, Texas, 78249, United States|Investigational Site Number 840207, Schertz, Texas, 78154, United States|Investigational Site Number 840615, Sealy, Texas, 77474, United States|Investigational Site Number 840097, Sugar Land, Texas, 77478, United States|Investigational Site Number 840460, Sugar Land, Texas, 77478, United States|Investigational Site Number 840514, Sugar Land, Texas, 77478, United States|Investigational Site Number 840530, Sugar Land, Texas, 77479, United States|Investigational Site Number 840008, Waco, Texas, 76710, United States|Investigational Site Number 840593, Waco, Texas, 76712, United States|Investigational Site Number 840809, Waxahachie, Texas, 75165, United States|Investigational Site Number 840651, Webster, Texas, 77598, United States|Investigational Site Number 840392, Clinton, Utah, 84015, United States|Investigational Site Number 840189, Saint George, Utah, 84790, United States|Investigational Site Number 840228, Salt Lake City, Utah, 84107, United States|Investigational Site Number 840765, West Jordan, Utah, 84088, United States|Investigational Site Number 840806, West Jordan, Utah, 84088, United States|Investigational Site Number 840580, Chatham, Virginia, 24541, United States|Investigational Site Number 840590, Chesapeake, Virginia, 23321, United States|Investigational Site Number 840788, Danville, Virginia, 24540, United States|Investigational Site Number 840706, Danville, Virginia, 24541, United States|Investigational Site Number 840736, Danville, Virginia, 24541, United States|Investigational Site Number 840575, Fredericksburg, Virginia, 22408, United States|Investigational Site Number 840662, Hampton, Virginia, 23666, United States|Investigational Site Number 840795, Lynchburg, Virginia, 24501, United States|Investigational Site Number 840605, Martinsville, Virginia, 24112, United States|Investigational Site Number 840620, Newport News, Virginia, 23606, United States|Investigational Site Number 840088, Norfolk, Virginia, United States|Investigational Site Number 840247, North Chesterfield, Virginia, 11042, United States|Investigational Site Number 840730, Pennington Gap, Virginia, 24277, United States|Investigational Site Number 840179, Richmond, Virginia, 23219, United States|Investigational Site Number 840076, Salem, Virginia, United States|Investigational Site Number 840354, Virginia Beach, Virginia, 23462, United States|Investigational Site Number 840704, Winchester, Virginia, 22601, United States|Investigational Site Number 840709, Everett, Washington, 98208, United States|Investigational Site Number 840238, Federal Way, Washington, 98003-8708, United States|Investigational Site Number 840588, Vancouver, Washington, 98664, United States|Investigational Site Number 840084, Walla Walla, Washington, 99362, United States|Investigational Site Number 840658, Charleston, West Virginia, 25304, United States|Investigational Site Number 840595, Lewisburg, West Virginia, 24901, United States|Investigational Site Number 124002, Barrie, L4N4L3, Canada|Investigational Site Number 124005, Brampton, L6S0C9, Canada|Investigational Site Number 124001, Brampton, L6T4V3, Canada|Investigational Site Number 124030, Burlington, L7R1A4, Canada|Investigational Site Number 124017, Calgary, T2H2G4, Canada|Investigational Site Number 124013, Concord, L4K4M2, Canada|Investigational Site Number 124018, Etobicoke, M9R4E1, Canada|Investigational Site Number 124014, Etobicoke, M9V4V4, Canada|Investigational Site Number 124026, Guelph, N1H1B1, Canada|Investigational Site Number 124008, Hamilton, L8K3P3, Canada|Investigational Site Number 124027, Hamilton, L8L5G8, Canada|Investigational Site Number 124010, London, N5W 6A2, Canada|Investigational Site Number 124015, Markham, L6B0P9, Canada|Investigational Site Number 124020, Montreal, H2R1V6, Canada|Investigational Site Number 124016, Newmarket, Canada|Investigational Site Number 124024, Oakville, L6M1M1, Canada|Investigational Site Number 124029, Saint-Laurent, H4T1Z9, Canada|Investigational Site Number 124007, Surrey, V4A1R6, Canada|Investigational Site Number 124003, Toronto, M4G3E8, Canada|Investigational Site Number 124025, Vancouver, V5X0C4, Canada
URL: https://clinicaltrials.gov/show/NCT02451137

Drug ID Drug Name Type DrugBank ID Targets Category Latest Progress