| Trial ID: | L5852 |
| Source ID: | NCT02951260
|
| Associated Drug: |
Metformin
|
| Title: |
The Effects of Metformin on Self-selected Exercise Intensity, Physical Fitness and Exercise-induced AMPK-activation
|
| Acronym: |
|
| Status: |
COMPLETED
|
| Study Results: |
NO
|
| Results: |
|
| Conditions: |
Diabetes Mellitus, Type 2
|
| Interventions: |
DRUG: Metformin|OTHER: Placebo
|
| Outcome Measures: |
Primary: Overall aerobic work performed during an exercise bout with self-selected intensity, Total oxygen consumption (L O2) during a 45 min ergometer cycling bout with self-selected intensity | Secondary: External work performed during an exercise bout with self-selected intensity, Total work produced (kJ) during a 45 min ergometer cycling bout with self-selected intensity|Rate of perceived exertion during an exercise bout with fixed intensity, Mean rate of perceived exertion (Borg scale) during a 45 min ergometer cycling bout with fixed intensity|blood lactate during an exercise bout with fixed intensity, Mean blood lactate (mmol/l) during a 45 min ergometer cycling bout with fixed intensity|Heartrate during an exercise bout with fixed intensity, Mean heart rate (bpm) during a 45 min ergometer cycling bout with fixed intensity|Respiratory exchange ratio during an exercise bout with fixed intensity, Mean VCO2/VO2 during a 45 min ergometer cycling bout with fixed intensity|Physical fitness (VO2max), maximal oxygen consumption (L/min) during a VO2 max test | Other: AMPK-activation in skeletal muscle during an exercise bout with fixed intensity, change in exercise induced AMPK-activation after compared to before a 45 min ergometer cycling bout with self-selected intensity|Oxidative phosphorylation in skeletal muscle fibers, Mitochondrial Complex I respiration in skeletal muscle tissue after 17 days of metformin/placebo treatment
|
| Sponsor/Collaborators: |
Sponsor: Rigshospitalet, Denmark | Collaborators: University of Copenhagen
|
| Gender: |
MALE
|
| Age: |
ADULT
|
| Phases: |
|
| Enrollment: |
15
|
| Study Type: |
INTERVENTIONAL
|
| Study Designs: |
Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
|
| Start Date: |
2016-10
|
| Completion Date: |
2017-07
|
| Results First Posted: |
|
| Last Update Posted: |
2017-09-27
|
| Locations: |
Center for aktiv sundhed, Copenhagen, Copenhagen N, 2200, Denmark
|
| URL: |
https://clinicaltrials.gov/show/NCT02951260
|
