| Outcome Measures: |
Primary: Symptom score in response to insulin-induced hypoglycaemia, Measured during hyperinsulinemic hypoglycaemic glucose clamps, 30 minutes | Secondary: Adrenaline response to insulin-induced hypoglycaemia, Measured in plasma during hyperinsulinemic hypoglycaemic glucose clamps, 30 minutes|Glucagon response to insulin-induced hypoglycaemia, Measured in plasma during hyperinsulinemic hypoglycaemic glucose clamps, 30 minutes|Time until glycaemic recovery from hypoglycaemia, Measured during hyperinsulinemic hypoglycaemic glucose clamps, 1 hour|Maximal glucose excursion post-hypoglycaemia, Measured during hyperinsulinemic hypoglycaemic glucose clamps, 1 hour|Time until glucose peak post-hypoglycaemia, Measured after hyperinsulinemic hypoglycaemic glucose clamps, 1 hour|Area under the glucose concentration curve post-hypoglycaemia, Measured after hyperinsulinemic hypoglycaemic glucose clamps, 1 hour|Hunger score post-hypoglycaemia, Measured after hyperinsulinemic hypoglycaemic glucose clamps, 1 hour|Carbohydrate requirement after recovery from hypoglycaemia, Measured after hyperinsulinemic hypoglycaemic glucose clamps by showing pictures of various carbohydrate-containing snacks and beverages, 1 hour|Number of severe hypoglycaemic events during follow-up, 16 weeks|Number of nocturnal hypoglycaemic events during follow-up, 16 weeks|Number of any hypoglycaemic events during follow-up, 16 weeks|Number of hypoglycaemic events measured by glucose sensor monitoring, optional (in participants agreeing to wear a continuous glucose sensor for 5 days), 1 week|Time spent under hypoglycaemic conditions measured by glucose sensor monitoring, optional (in participants agreeing to wear a continuous glucose sensor for 5 days), 1 week|Glucose variability as measured by glucose sensor monitoring, optional (in participants agreeing to wear a continuous glucose sensor for 5 days), 1 week | Other: Pulse rate, Measured during hyperinsulinemic hypoglycaemic glucose clamps, 6 weeks|Gastrointestinal side effects, 16 weeks
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