| Trial ID: | L0619 |
| Source ID: | NCT02841280
|
| Associated Drug: |
Chlorthalidone
|
| Title: |
Chlorthalidone in Chronic Kidney Disease
|
| Acronym: |
CLICK
|
| Status: |
COMPLETED
|
| Study Results: |
YES
|
| Results: |
https://ClinicalTrials.gov/show/NCT02841280/results
|
| Conditions: |
Renal Insufficiency, Chronic|Hypertension
|
| Interventions: |
DRUG: Chlorthalidone|DRUG: Placebo
|
| Outcome Measures: |
Primary: Change From Baseline to 12 Weeks in Systolic Ambulatory Blood Pressure in the Chlorthalidone Group Compared to Placebo., Baseline to 12 weeks | Secondary: Changes in Albuminuria From Baseline at Each 4 Week Visit in the Log Transformed Albumin/Creatinine Ratio in the Chlorthalidone Group Compared to Placebo, Baseline to 12 weeks|Change From Baseline at Each 4 Week Visit in Log of Aldosterone and Log of Renin in the Chlorthalidone Group Compared to Placebo. No Adjustments Will be Made for Multiple Comparisons., Baseline to 12 weeks|Change From Baseline at Each 4 Week Visit in Log of N-terminal Pro B-type Natriuretic Peptide (NTproBNP) in the Chlorthalidone Group Compared to Placebo. No Adjustments Will be Made for Multiple Comparisons., Baseline to 12 weeks|Change From Baseline at Each 4 Week Visit in Body Volume in the Chlorthalidone Group Compared to Placebo. No Adjustments Will be Made for Multiple Comparisons., Baseline to 12 weeks
|
| Sponsor/Collaborators: |
Sponsor: Indiana University
|
| Gender: |
ALL
|
| Age: |
ADULT, OLDER_ADULT
|
| Phases: |
PHASE2
|
| Enrollment: |
160
|
| Study Type: |
INTERVENTIONAL
|
| Study Designs: |
Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
|
| Start Date: |
2016-07
|
| Completion Date: |
2021-04
|
| Results First Posted: |
2022-03-31
|
| Last Update Posted: |
2023-05-15
|
| Locations: |
Indiana University School of Medicine, Division of Nephrology, Indianapolis, Indiana, 46202, United States
|
| URL: |
https://clinicaltrials.gov/show/NCT02841280
|
