| Outcome Measures: |
Primary: Effective Renal Plasma Flow (ERPF), Measured by PAH clearance, 4 Hours|Glomerular Filtration Rate, Measured by Iohexol Clearance, 4 Hours|Glomerular Size Selectivity, Measured by Dextran sieving, 4 hours|Renal Oxygen Availability, Measured by functional kidney MRI, 1 hour|Renal Perfusion, Measured by functional kidney MRI + PET Scan, 1 hour|11-C Acetate Tracer Uptake, Measured by PET Scan, 1 Hour|Renal Oxidative Metabolism, Measured by PET Scan, 1 Hour|Blood Volume Fraction, Measured by PET Scan, 1 Hour|Glomerular Basement Membrane Width, Measured by Renal Biopsy, 1 Hour|Mesangial Expansion, Measured by Renal Biopsy, 1 Hour|Interstitial Fibrosis, Measured by Renal Biopsy, 1 Hour|Renal Arteriosclerosis, Measured by Renal Biopsy, 1 Hour|Spatial Transcriptomics, Measured by Renal Biopsy, 1 Hour|Spatial Metabolomics, Measured by Renal Biopsy, 1 Hour | Secondary: Pulse Wave Velocity between Carotid and Femoral Artery, Measured by PWV, 10 minutes|Whole brain gray matter volume, Measured by brain MRI, 1 Hour|Whole brain cortical thickness, Measured by brain MRI, 1 Hour|Whole brain resting-state network connectivity, Measured by brain MRI, 1 Hour|Age-corrected composite fluid cognition score, Measured by brain MRI, 1 Hour
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