| Outcome Measures: |
Primary: Insulin and growth hormone signalling, expressed as CHANGE in phosphorylation of intracellular target proteins and mRNA expression of target genes in muscle- and fat-tissue., Change in phosphorylation of target proteins and mRNA expression of target genes assessed with western blotting technique., Biopsies obtained on each study day (arm). Muscle biopsies: time (t)= -30min, t= 30min and t= 75min. Fat biopsies: t= 30min and t= 75min | Secondary: Intracellular markers of lipid metabolism in muscle- and fat tissue biopsies., Assessed by Western blotting., Biopsies obtained on each study day (arm). Muscle biopsies: time (t)= -30min, t= 30min and t= 75min. Fat biopsies: t= 30min and t= 75min|Metabolism., Assessment of glucose metabolism by forearm pletysmography and heated hand technique (duration of pletysmography = 30 min.), measured twice on each study day (arm) at t= -30-0 min. and t= 50-80 min.|Ghrelin, Measured at t = -30min., t=0min, t=15min, t= 30min., t=45min., t=60min., t= 75min., t=90min. and t=105min. on each study day (arm)|Metabolism, A palmitic acid tracer will be given once per trial day to estimate fatty acid metabolism. Duration 1 hour., once per study day (arm): t 45min - 105min.
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