| Trial ID: | L6278 |
| Source ID: | NCT01000688
|
| Associated Drug: |
Vildagliptin + Acarbose
|
| Title: |
Vildagliptin and Endothelium-dependent Vasodilatation
|
| Acronym: |
|
| Status: |
COMPLETED
|
| Study Results: |
NO
|
| Results: |
|
| Conditions: |
Type 2 Diabetes|Endothelial Dysfunction
|
| Interventions: |
DRUG: vildagliptin + acarbose|DRUG: acarbose + vildagliptin
|
| Outcome Measures: |
Primary: Forearm vasodilator response to intra-arterial infusion of acetylcholine (endothelium-dependent) following treatment with vildagliptin and following active control with acarbose, 8 weeks | Secondary: Effect of vildagliptin on inflammatory markers and adipokines, 8 weeks|Effect of vildagliptin on fat cell morphology and gene expression, 8 weeks|Effect of vildagliptin on ex vivo mononuclear cell responses to various stimuli, 8 weeks
|
| Sponsor/Collaborators: |
Sponsor: Radboud University Medical Center
|
| Gender: |
ALL
|
| Age: |
ADULT, OLDER_ADULT
|
| Phases: |
PHASE3
|
| Enrollment: |
16
|
| Study Type: |
INTERVENTIONAL
|
| Study Designs: |
Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
|
| Start Date: |
2010-01
|
| Completion Date: |
2010-10
|
| Results First Posted: |
|
| Last Update Posted: |
2010-11-05
|
| Locations: |
Radboud University Nijmegen Medical Centre, Nijmegen, 6500 HB, Netherlands
|
| URL: |
https://clinicaltrials.gov/show/NCT01000688
|
