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Clinical Trial Details

Trial ID: L6333
Source ID: NCT01594333
Associated Drug: Methotrexate
Title: Cardiovascular Inflammation Reduction Trial
Acronym: CIRT
Status: COMPLETED
Study Results: YES
Results: https://ClinicalTrials.gov/show/NCT01594333/results
Conditions: Cardiovascular Disease
Interventions: DRUG: Methotrexate|DRUG: Placebo
Outcome Measures: Primary: Number of Subjects With Major Adverse Cardiovascular Events, The first occurrence of Major Adverse Cardiovascular Event which is defined as the occurrence of one or more of the following: Cardiovascular Death, Non-Fatal Myocardial Infarction or Non-Fatal Stroke., From randomization to trial end (April 2, 2018) up to a maximum of 5 years|Number of Subjects With Major Adverse Cardiovascular Event or Hospitalization for Unstable Angina That Led to Urgent Coronary Revascularization, The first occurrence of Major Adverse Cardiovascular Event or Hospitalization for Unstable Angina that led to Urgent Coronary Revascularization., From randomization to trial end (April 2, 2018) - up to a maximum of 5 years | Secondary: Number of Subjects With All-cause Mortality, Subjects who died from any cause., From randomization to the trial end (April 2, 2018) up to a maximum of 5 years|Number of Subjects With Major Adverse Cardiovascular Event or Any Coronary Revascularization, The first occurrence of Major Adverse Cardiovascular Event or Any Coronary Revascularization., From randomization to the trial end (April 2, 2018) - up to a maximum of 5 years|Number of Subjects With Hospitalization for Congestive Heart Failure, The first occurrence of Hospitalization for Congestive Heart Failure, From randomization to trial end (April 2, 2018) up to a maximum of 5 years|Number of Subjects With Major Adverse Cardiovascular Event, Coronary Revascularization, Hospitalization for Congestive Heart Failure or All Cause Mortality, The first occurrence of Major Adverse Cardiovascular Event, Coronary Revascularization, Hospitalization for Congestive Heart Failure or All Cause Mortality., From randomization to trial end (April 2, 2018) up to a maximum of 5 years|Number of Subjects With New Onset Type 2 Diabetes, New onset type 2 diabetes among those without diabetes at baseline. Baseline diabetes is defined as any of the following prior to randomization: clinician report of diabetes, use of antidiabetic medication, hbA1c \>=6.5 or fasting plasma glucose \>=126., From randomization to the trial end (April 2, 2018) - up to 5 years | Other: Number of Subjects With Hospitalization for Unstable Angina That Led to Unplanned Coronary Revascularization, The first occurrence of hospitalization for unstable angina that led to unplanned coronary revascularization, From randomization to the trial end (April 2, 2018) up to 5 years|Number of Subjects With Coronary Revascularization, The first occurrence of coronary revascularization, From randomization to trial end (April 2, 2018) up to 5 years|Number of Subjects With Peripheral Artery Disease, The first occurrence of new or worsening of peripheral artery disease, From randomization to the trial end (April 2, 2018) - up to 5 years|Number of Subjects With Deep Vein Thrombosis or Pulmonary Embolism, The first occurrence of symptomatic deep vein thrombosis or pulmonary embolism, From randomization to the trial end (April 2, 2018) - up to 5 years|Number of Subjects With Aortic Stenosis, The first occurrence of clinically significant aortic stenosis, From randomization to the trial end (April 2, 2018) - up to 5 years|Number of Subjects With Atrial Fibrillation, The first occurrence of new or worsening of atrial fibrillation, From randomization to the trial end (April 2, 2018) - up to 5 years
Sponsor/Collaborators: Sponsor: Brigham and Women's Hospital | Collaborators: National Heart, Lung, and Blood Institute (NHLBI)
Gender: ALL
Age: ADULT, OLDER_ADULT
Phases: PHASE3
Enrollment: 4786
Study Type: INTERVENTIONAL
Study Designs: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Start Date: 2013-04
Completion Date: 2019-10-30
Results First Posted: 2020-07-24
Last Update Posted: 2020-07-24
Locations: University of Alabama at Birmingham, Birmingham, Alabama, 35294, United States|Appalachian Research Associates, Fort Payne, Alabama, 35967, United States|Avant Research Associates, LLC, Guntersville, Alabama, 35976, United States|Saadat Ansari MD LLC, Huntsville, Alabama, 35801, United States|University of South Alabama: Division of Clinical Research, Mobile, Alabama, 36617, United States|Heart Vascular of Northern Arizona, Cottonwood, Arizona, 86326, United States|CardioVascular Associates of Mesa, Mesa, Arizona, 85206, United States|Arizona Arthritis & Rheumatology Research, Phoenix, Arizona, 85032, United States|Scottsdale Medical Imaging, Scottsdale, Arizona, 85258, United States|The Heart Clinic, Scottsdale, Arizona, 85258, United States|Pima Heart, Tucson, Arizona, 85718, United States|Southern Arizona VA Health Care System, Tucson, Arizona, 85723, United States|Arkansas Cardiology, Little Rock, Arkansas, 72205, United States|Arkansas Heart Hospital, Little Rock, Arkansas, 72211, United States|Oracle Clinical Research, Inc., Anaheim, California, 92801, United States|Medical Group of Culver City, Culver City, California, 90230, United States|Touro University California- Solano County Affiliated Clinics, Fairfield, California, 94533, United States|University Of California San Francisco, Fresno, California, 93701, United States|VACCHCS, Fresno, California, 93703, United States|UCSD Sulpizio Cardiovascular Center, La Jolla, California, 92037, United States|University Of California San Diego, La Jolla, California, 92093, United States|Desert Medical Care & Wellness, La Quinta, California, 92253, United States|Kumar Medical Corporation, Lancaster, California, 93534, United States|Loma Linda University Health, Loma Linda, California, 92354, United States|VA Loma Linda Healthcare System, Loma Linda, California, 92357, United States|Long Beach Center for Clinical Research, Long Beach, California, 90807, United States|Cardiovascular Innovation and Research, Long Beach, California, 90813, United States|Los Alamitos Cardiovascular, Los Alamitos, California, 90720, United States|Faye Montegrande Md. Clinical Research, Los Angeles, California, 90004, United States|Eastside Clinical Research Associates, Los Angeles, California, 90022, United States|Salman Khan A. Medical Corporation, Los Angeles, California, 90033, United States|University of Southern California, Los Angeles, California, 90033, United States|West LA VA Medical Center, Los Angeles, California, 90049, United States|VA Northern California Health Care, Mather, California, 95655, United States|Valley Clinical Trials, Inc., Northridge, California, 91325, United States|Orange County Heart Institute & Research, Orange, California, 92868, United States|University of CA Irvine Medical Center, Orange, California, 92868, United States|Diverse Research Solutions, Oxnard, California, 93030, United States|Huntington Memorial Hospital, Pasadena, California, 91105, United States|Central Coast Cardiology, Salinas, California, 93901, United States|Richard G. Friedman, MD, San Diego, California, 92103, United States|Ritchken and First MDs, San Diego, California, 92117, United States|Foundation for Cardiovascular Medicine, San Diego, California, 92121, United States|San Diego Cardiac Center, San Diego, California, 92123, United States|Veterans Affairs San Diego Healthcare System, San Diego, California, 92161, United States|UCSF at Zuckerberg SF General Hospital, San Francisco, California, 94110, United States|Coastal Heart Medical Group, Inc., Santa Ana, California, 92704, United States|Comprehensive Cardiovascular Care, Santa Maria, California, 93454, United States|Pacific Heart and Vascular Medical Group, Stockton, California, 95210, United States|Manoj D. Aswani M.D., Thousand Oaks, California, 91360, United States|Touro University California- Solano Public Health Affiliated Clinics, Vallejo, California, 94592, United States|Munni R. Selagamsetty, Md, Pc, Colorado Springs, Colorado, 80910, United States|Vijay - Aurora Denver Cardiology, Denver, Colorado, 80218, United States|Colorado Health Medical Group Heart Center of the Rockies, Fort Collins, Colorado, 80528, United States|Medical Center of the Rockies Research, Fort Collins, Colorado, 80528, United States|Unrein - Rocky Vista University Health Center, Parker, Colorado, 80134, United States|Connecticut Heart and Vascular Center, Bridgeport, Connecticut, 06606, United States|Bridgeport Hospital, Bridgeport, Connecticut, 06610, United States|Cardiology Physicians/Red Clay Research, Newark, Delaware, 19713, United States|Boisey Barnes MD, PC, Washington, District of Columbia, 20024, United States|GWU Medical Faculty Associatin, Inc., Washington, District of Columbia, 20037, United States|Pianko - Aventura Research Center, LLC, Aventura, Florida, 33180, United States|North Ridge Heart Associates, Boca Raton, Florida, 33434, United States|St. Francis Medical Institute, Clearwater, Florida, 33765, United States|Gonzalez MD & Aswad MD Health Ser, Coral Gables, Florida, 33134, United States|American Research Institute, Inc., Cutler Bay, Florida, 33157, United States|Daytona Heart Group, Daytona Beach, Florida, 32114, United States|Daytona Heart Group, DeLand, Florida, 32720, United States|Seidman Clinical Trials, Delray Beach, Florida, 33484, United States|Steven Cohen MD, Delray Beach, Florida, 33484, United States|Infinite Clinical Research, Doral, Florida, 33126, United States|International Research Partners, LLC, Doral, Florida, 33166, United States|Medical Research Institute at Doral, Inc., Doral, Florida, 33178, United States|Lake Internal Medicine Assocaties, Eustis, Florida, 32726, United States|Invesclinic, Fort Lauderdale, Florida, 33308, United States|Primary Care Associates, Fort Myers, Florida, 33907, United States|Lee Physician Group, Fort Myers, Florida, 33908, United States|The Cardiac and Vascular Institute, Gainesville, Florida, 32605, United States|University of Florida, Gainesville, Florida, 32610, United States|Qway Research, Hialeah, Florida, 33010, United States|State of the Art Research, Hialeah, Florida, 33010, United States|Healing Touch C&C Research, Hialeah, Florida, 33012, United States|Luzmed Clinical Research Institute, Hialeah, Florida, 33012, United States|Viviana Perez MD Research & Cosmetics, Hialeah, Florida, 33012, United States|Elite Cardiac Research Center LLC, Hialeah, Florida, 33013, United States|Nova Clinical Research Clinic, Hialeah, Florida, 33013, United States|Best Quality Research, Inc., Hialeah, Florida, 33016, United States|South Florida Research Solutions, LLC, Hollywood, Florida, 33021, United States|John Gutleber Medical Research Office, Homestead, Florida, 33030, United States|Cardiovascular Medical Associates of Palm Beach, Jupiter, Florida, 33458, United States|Hope Clinical Research, Kissimmee, Florida, 34758, United States|SIH Research, LLC, Kissimmee, Florida, 34759, United States|Lakes Research, LLC, Miami Lakes, Florida, 33014, United States|Veritas Research Corp., Miami Lakes, Florida, 33014, United States|Ocean Blue Medical Research Center, Miami Springs, Florida, 33166, United States|Medical Research Center of Florida, Miami, Florida, 33122, United States|LG Diagnostics, Inc., Miami, Florida, 33126, United States|St. Paul Medical Research Center, Inc., Miami, Florida, 33126, United States|Team Medical Research, Miami, Florida, 33134, United States|Paradise Clinical Research, LLC, Miami, Florida, 33144, United States|GAD Research Center, Miami, Florida, 33155, United States|Innovation Research Institute, Inc., Miami, Florida, 33155, United States|Sanitas Research, Miami, Florida, 33155, United States|Segui - Med Care Research, Miami, Florida, 33165, United States|South Florida Research Group, LLC, Miami, Florida, 33176, United States|Vista Health Research, LLC, Miami, Florida, 33176, United States|D De La Vega MD Research Group, Miami, Florida, 33186, United States|Southwest Florida Research, LLC, Naples, Florida, 34102, United States|Orlando Healthy Heart Institute, Orlando, Florida, 32806, United States|Palm Beach Gardens Research Center, LLC, Palm Beach Gardens, Florida, 33410, United States|Broward Research Center, Pembroke Pines, Florida, 33024, United States|Pioneer Clinical Research, Pembroke Pines, Florida, 33024, United States|Sandoval - Broward Research Center, Pembroke Pines, Florida, 33204, United States|Bay Area Heart Center: 49th Street, Saint Petersburg, Florida, 33705, United States|Bay Area Heart Center: 7th Avenue, Saint Petersburg, Florida, 33705, United States|Lenus Research & Medical Group, Sweetwater, Florida, 33172, United States|DBC Research, Tamarac, Florida, 33321, United States|Asclepes Research Centers, Weeki Wachee, Florida, 34607, United States|Gupta - Premier Heart and Vascular Center, Wesley Chapel, Florida, 33544, United States|Athens Regional Medical Center, Athens, Georgia, 30606, United States|Atlanta Veterans Affairs Medical Center, Atlanta, Georgia, 30033, United States|Laureate Medical Group at Northside, Atlanta, Georgia, 30308, United States|Synergy Therapeutic Partners, Atlanta, Georgia, 30308, United States|Northside Hospital, Atlanta, Georgia, 30342, United States|Atlanta Heart Specialists, LLC, Cumming, Georgia, 30041, United States|Heart and Rhythm Specialists, Dalton, Georgia, 30720, United States|Albert F. Johary MD, PC, Dunwoody, Georgia, 30338, United States|Infinite Clinical Trials, Riverdale, Georgia, 30274, United States|Atlanta Vanguard Medical Associates, Smyrna, Georgia, 30082, United States|Herman Clinical Research, LLC, Suwanee, Georgia, 30024, United States|Atlanta Heart Specialists, LLC, Tucker, Georgia, 30084, United States|Cardiology Associates of Vidalia, P.C., Vidalia, Georgia, 30474, United States|VA Pacific Islands Health Care System, Honolulu, Hawaii, 96819, United States|St. Luke's Idaho Cardiology Associates, Boise, Idaho, 83712, United States|Clinical Research Prime, Idaho Falls, Idaho, 83404, United States|Northwest Heart Clinical Research, Arlington Heights, Illinois, 60005, United States|University of Chicago Medical Center, Chicago, Illinois, 60637, United States|Advocate Med Group-Heart & Vascular Of Illinois, Chicago, Illinois, 60657, United States|Illinois Heart & Lung Research Center, SC, Normal, Illinois, 61761, United States|Captain James A. Lovell Federal Health, North Chicago, Illinois, 60064, United States|Specialty Physicians of Illinois, LLC, Olympia Fields, Illinois, 60461, United States|Advanced CardioVascular Consultants, Rock Island, Illinois, 61201, United States|Cardiospecialists, LTD, Dyer, Indiana, 46311, United States|Martin - Martin Family Practice and Research, Evansville, Indiana, 47714, United States|Krannert Institute Of Cardiology, Indianapolis, Indiana, 46202, United States|Community Hospital South, Indianapolis, Indiana, 46227, United States|Indiana Heart Physicians, Indianapolis, Indiana, 46237, United States|Medical Consultants, PC, Muncie, Indiana, 47303, United States|Iowa Heart Center, West Des Moines, Iowa, 50266, United States|Stahl - Midwest Heart & Vascular Specialists, Overland Park, Kansas, 66209, United States|Professional Research Network of KS, Wichita, Kansas, 67203, United States|Robert J. Dole VAMC, Wichita, Kansas, 67230, United States|University of Kentucky, Lexington, Kentucky, 40536, United States|Robley Rex VAMC, Louisville, Kentucky, 40202, United States|Stoddard - University of Louisville, Louisville, Kentucky, 40202, United States|Bays - L-MARC Research Center, Louisville, Kentucky, 40213, United States|Research Integrity LLC, Owensboro, Kentucky, 42303, United States|Dorothy H. Banish, MD, APMC Study Group, Covington, Louisiana, 70433, United States|Avant Research Associates, LLC, Crowley, Louisiana, 70526, United States|North Oaks Cardiology, Hammond, Louisiana, 70403, United States|American Clinical Research, LLC, Marrero, Louisiana, 70072, United States|Otis Barnum D.O.P.C., Natchitoches, Louisiana, 71457, United States|Tulane University Office of Health Research, New Orleans, Louisiana, 70112, United States|Veterans Affairs Medical Center Shreveport, Shreveport, Louisiana, 71101, United States|Maine Research Associates, Auburn, Maine, 04210, United States|Paul A. Shapero, M.D., Bangor, Maine, 04401, United States|Southern Maine Health Care, Biddeford, Maine, 04005, United States|InterMed, PA, Portland, Maine, 04101, United States|Maine Medical Partners Maine Health Cardiology, South Portland, Maine, 04106, United States|Maine Centers for Healthcare, Westbrook, Maine, 04092, United States|Sinai Center for Thrombosis Research, Baltimore, Maryland, 21215, United States|St. Mary's Medical Center, Charlotte Hall, Maryland, 20622, United States|Calvert Memorial Hospital, Clinton, Maryland, 20735, United States|Shah Associates, MD, LLC, Prince Frederick, Maryland, 20678, United States|Peninsula Cardiology Associates, Salisbury, Maryland, 21804, United States|IRC Clinics, Towson, Maryland, 21204, United States|Brigham and Women's Hospital, Boston, Massachusetts, 02115, United States|St. Elizabeth's Medical Center, Boston, Massachusetts, 02135, United States|MGH Cardiology, Boston, Massachusetts, 02214, United States|Joslin Diabetes Center, Boston, Massachusetts, 02215, United States|Lahey Hospital and Medical Center, Burlington, Massachusetts, 01805, United States|Massachusetts General Hospital - Chelsea Health Care Center, Chelsea, Massachusetts, 02150, United States|Pentucket Medical Associates, Inc., Haverhill, Massachusetts, 01830, United States|VA Central Western Massachusetts Healthca, Leeds, Massachusetts, 01053, United States|South Shore Internal Medicine, Milton, Massachusetts, 02186, United States|Lahey Medical Center, Peabody, Massachusetts, 02149, United States|North Shore Cardiovascular Associates, Salem, Massachusetts, 01907, United States|Reliant Medical Group, Worcester, Massachusetts, 01608, United States|Endeavor Medical Research, Alpena, Michigan, 49707, United States|John D. Dingell Veterans Affairs Medical Center, Detroit, Michigan, 48201, United States|Trace Research Group at Wayne State University, Detroit, Michigan, 48201, United States|Henry Ford Hospital, Detroit, Michigan, 48202, United States|Flint Clinical Research, Flint, Michigan, 48503, United States|Apex Medical Research MI, Inc., Flint, Michigan, 48504, United States|Garden City Hospital, Garden City, Michigan, 48135, United States|Genesys Regional Medical Center, Grand Blanc, Michigan, 48439, United States|National Clinical LLC, Hamtramck, Michigan, 48212, United States|Academic Cardiology Associates PC, Rochester Hills, Michigan, 48307, United States|Beaumont Health Center, Royal Oak, Michigan, 48073, United States|Covenant Medical Center, Inc., Saginaw, Michigan, 48602, United States|Mid-Michigan Heart & Vascular Center, Saginaw, Michigan, 48609, United States|Centra Care Heart & Vascular Center at St. Cloud Hospital, Saint Cloud, Minnesota, 56303, United States|United Heart and Vascular Clinic, Saint Paul, Minnesota, 55102, United States|Gulfside Clinical Research, LLC, Gulfport, Mississippi, 39501, United States|University of MS Medical Center, Jackson, Mississippi, 39216, United States|David M. Headley M.D. PA Planters Clinic, Port Gibson, Mississippi, 39150, United States|Stern Cardiovascular Foundation, Inc., Southaven, Mississippi, 38671, United States|Center for Advanced Medicine and Research LLC, Bridgeton, Missouri, 63044, United States|Clinical Research Center University of Missouri, Columbia, Missouri, 65212, United States|Quantum Research LLC, Festus, Missouri, 63028, United States|Midwest Cardiology Associates, Independence, Missouri, 64057, United States|Freeman Health System, Joplin, Missouri, 64804, United States|VA Medical Center Kansas City, Kansas City, Missouri, 64128, United States|Lake Regional Cardiovascular Institute, Osage Beach, Missouri, 65065, United States|VA St. Louis Health Care System (VASTLHCS), Saint Louis, Missouri, 63106, United States|SLUCare Cardiology, Saint Louis, Missouri, 63110, United States|Washington University, Saint Louis, Missouri, 63110, United States|Clinical Investigators LLC, Saint Louis, Missouri, 63119, United States|Consult and Research Associates, Saint Louis, Missouri, 63122, United States|Center for Advanced Medicine and Research, Saint Peters, Missouri, 63303, United States|CoxHealth: Wheeler Heart & Vascular Center, Springfield, Missouri, 65807, United States|Mercy Medical Research Institute, Springfield, Missouri, 65807, United States|Great Falls Clinic Clinical Research Deptartment, Great Falls, Montana, 59420, United States|Cone - Montana Medical Research, Missoula, Montana, 59801, United States|Barrett Clinic, P.C., La Vista, Nebraska, 68128, United States|Heart Consultants, Omaha, Nebraska, 68114, United States|Alegent Creighton Health, Omaha, Nebraska, 68131, United States|University of Nebraska Medical Center, Omaha, Nebraska, 68198, United States|Internal Medicine Clinic, Las Vegas, Nevada, 89102, United States|Red Rock Clinical Research, LLC, Las Vegas, Nevada, 89146, United States|Sierra Nevada Health Care System, Reno, Nevada, 89502, United States|Renown Inst for Heart & Vasc Health, Reno, Nevada, 89503, United States|Lahey Cardiology, Nashua, New Hampshire, 03060, United States|Family Health at Mount Olive, Flanders, New Jersey, 07836, United States|Cardiocare, Hillsborough, New Jersey, 08844, United States|New Jersey Heart, Linden, New Jersey, 07063, United States|Jersey Shore University Medical Center, Neptune, New Jersey, 07753, United States|Cardiovascular Institute, New Brunswick, New Jersey, 08901, United States|Palisade Medical Center, North Bergen, New Jersey, 07047, United States|The Valley Hospital, Ridgewood, New Jersey, 07450, United States|Mercer Bucks Cardiology, Robbinsville, New Jersey, 08691, United States|Cardio Metabolic Institute, Somerset, New Jersey, 08873, United States|Holy Name Medical Center, Inc., Teaneck, New Jersey, 07666, United States|Total Cardiology Care, LLC, Wayne, New Jersey, 07470, United States|Westwood Cardiology Associates, Westwood, New Jersey, 07675, United States|Presbyterian Heart Group, Albuquerque, New Mexico, 87106, United States|Albany Medical College, Albany, New York, 12208, United States|Albany Stratton VA Medical Center, Albany, New York, 12208, United States|Novel Research of New York, LLC, Bronx, New York, 10461, United States|Montefiore Medical Center, Bronx, New York, 10467, United States|Brown - SUNY Downstate Medical Center, Brooklyn, New York, 11203, United States|Buffalo Heart Group, Buffalo, New York, 14215, United States|Bassett Healthcare Network, Cooperstown, New York, 13326, United States|NYU Hudson Valley Cardiology, Cortlandt Manor, New York, 10567, United States|NYHQ, Flushing, New York, 11355, United States|Jamaica Hospital Medical Center, Jamaica, New York, 11418, United States|Long Island Heart Associates, Mineola, New York, 11501, United States|Winthrop University Hospital, Mineola, New York, 11501, United States|Long Island Jewish Medical Center, New Hyde Park, New York, 11040, United States|Queens Long Island Medical Group, New Hyde Park, New York, 11577, United States|Chinatown Cardiology, PC, New York, New York, 10013, United States|Weill Cornell Medical College and NY Presbyterian, New York, New York, 10021, United States|Mount Sinai School of Medicine, New York, New York, 10029, United States|DiGiovanna Institute for Medical Education and Research, North Massapequa, New York, 11758, United States|Champlain Valley Physician Hospital, Plattsburgh, New York, 12901, United States|Cardiology Associates of Schenectady, Schenectady, New York, 12309, United States|Clinical Study Center of Asheville, Asheville, North Carolina, 28801, United States|Metrolina Internal Medicine, Charlotte, North Carolina, 28204, United States|Gaffney Health Services, Charlotte, North Carolina, 28205, United States|Carolinas Research Center, Charlotte, North Carolina, 28215, United States|Eastern Carolina Cardiovascular, PA, Elizabeth City, North Carolina, 27909, United States|Eastern Cardiology, Greenville, North Carolina, 27834, United States|Northside Clinical Research, Lenoir, North Carolina, 28645, United States|Lake Shore Clinical Research, LLC., Mooresville, North Carolina, 28117, United States|Carteret Medical Group, Morehead City, North Carolina, 28557, United States|Cardiology Associates of Carolinas, PA, Morganton, North Carolina, 28655, United States|Eastern Nephrology Associates, PLLC, New Bern, North Carolina, 28562, United States|Boice Willis Clinic, Rocky Mount, North Carolina, 27804, United States|Sanford Cardiology, Sanford, North Carolina, 27330, United States|Natalie A. Doyle, MD, PA, Wilson, North Carolina, 27893, United States|Altru Health System Rehab Center, Grand Forks, North Dakota, 58201, United States|Akron General Medical Center, Akron, Ohio, 44307, United States|Ohio University Heritage College of Osteopathic Medicine, Athens, Ohio, 45701, United States|Diabetes and Endocrinology Associates of Stark Cit, Canton, Ohio, 44718, United States|The Lindner Research Center, Cincinnati, Ohio, 45219, United States|Cleveland Clinic, Cleveland, Ohio, 44195, United States|Optimed Research, LTD, Columbus, Ohio, 43235, United States|Dayton Heart Center, Dayton, Ohio, 45414, United States|Dayton Veteran Affairs Medical Center, Dayton, Ohio, 45428, United States|Colonnade Medical Group, Lancaster, Ohio, 43130, United States|Middletown Cardiovascular Associates, Middletown, Ohio, 45044, United States|Comprehensive Heart Care, Inc., Toledo, Ohio, 43606, United States|Mount Carmel Clinical Cardiovascular Care, Westerville, Ohio, 43081, United States|Premier Physicians, Westlake, Ohio, 44154, United States|Wooster Heart Group, Wooster, Ohio, 44691, United States|Unity Clinical Research, Lindsay, Oklahoma, 73052, United States|COR Clinical Research, LLC, Oklahoma City, Oklahoma, 73103, United States|Thadani - VA Medical Center Oklahoma City, OK, Oklahoma City, Oklahoma, 73104, United States|Today Clinical Research, Oklahoma City, Oklahoma, 73129, United States|Cardiovascular Health Clinic, Oklahoma City, Oklahoma, 73134, United States|Oklahoma State University Center for Health Sciences, Tulsa, Oklahoma, 74127, United States|Samaritan Health Services, Corvallis, Oregon, 97330, United States|Southern Oregon Cardiology, LLC, Medford, Oregon, 97504, United States|Oregon Health & Science University, Portland, Oregon, 97239, United States|Center for Clinical Res. Abington Health, Abington, Pennsylvania, 19001, United States|St. Luke's University Hospital, Bethlehem, Pennsylvania, 18018, United States|Renu-Ca Research Institute, Lower Bucks Hospital, Bristol, Pennsylvania, 19007, United States|Main Line Health Center, Broomall, Broomall, Pennsylvania, 19008, United States|Spirit Physician Services, Inc, Camp Hill, Pennsylvania, 17011, United States|The Chambersburg Hospital, Chambersburg, Pennsylvania, 17201, United States|Central Bucks Cardiology, Doylestown, Pennsylvania, 18901, United States|Altoona Center for Clinical Research, Duncansville, Pennsylvania, 16635, United States|Heart Specialists of Lancaster County, Ephrata, Pennsylvania, 17522, United States|Saint Vincent Consultants in Cardiovascular Diseases, LLC, Erie, Pennsylvania, 16502, United States|Feasterville Family Healthcare Center, Feasterville, Pennsylvania, 19053, United States|Christiana Care Health System, Glen Mills, Pennsylvania, 19342, United States|Pinnacle Health Cardiovascular Institute, Harrisburg, Pennsylvania, 17110, United States|George Isajiw, MD, Lansdowne, Pennsylvania, 19050, United States|Bucks County Clinical Research, Morrisville, Pennsylvania, 19067, United States|Drexel University College of Medicine, Philadelphia, Pennsylvania, 19102, United States|Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, 19104, United States|Lehigh Valley Health Services, Sellersville, Pennsylvania, 18960, United States|Pish Medical Associates, Inc., Uniontown, Pennsylvania, 15401, United States|Lehigh Valley Family Practice, Whitehall, Pennsylvania, 18052, United States|Wilkes-Barre VA Medical Center, Wilkes-Barre, Pennsylvania, 18711, United States|Partners in Clinical Research, Cumberland, Rhode Island, 02864, United States|Ocean State Clinical Research Prtnr, Lincoln, Rhode Island, 02865, United States|Memorial Hospital of Rhode Island, Pawtucket, Rhode Island, 02860, United States|The Miriam Hospital, Providence, Rhode Island, 02906, United States|Ocean State Research Institute, Inc, Providence, Rhode Island, 02908, United States|South Carolina Heart Center, Columbia, South Carolina, 29204, United States|Amistad Research Center, LLC, Columbia, South Carolina, 29223, United States|Charlotte Hearts, Indian Land, South Carolina, 29707, United States|Miller - SC Internal Medicine Associates.: Irmo, Irmo, South Carolina, 29063, United States|Inlet Cardiopulmonary & Associates, Pawleys Island, South Carolina, 29585, United States|Fusion Clinical Research of Spartanburg, Spartanburg, South Carolina, 29301, United States|Palmetto Research Center, LLC, Spartanburg, South Carolina, 29302, United States|New Phase Research & Development, Chattanooga, Tennessee, 37409, United States|Parkway Medical Group, Fayetteville, Tennessee, 37334, United States|Stern Cardiovascular Foundation, Inc., Germantown, Tennessee, 38138, United States|Kore Cardiovascular Research Institutue, Jackson, Tennessee, 38305, United States|New Phase Research & Development, Knoxville, Tennessee, 37909, United States|Cardiovascular Research of Knoxville, Knoxville, Tennessee, 37917, United States|Ramanathan - VAMC Memphis, Memphis, Tennessee, 38104, United States|Clinical Research Center Meharry Medical College, Nashville, Tennessee, 37208, United States|Avant Research Associates LLC, Austin, Texas, 78704, United States|Texas Heart and Vascular Research, LLC, Austin, Texas, 78745, United States|Southeast TX Clinical Research Center, Beaumont, Texas, 77702, United States|Cornerstone Family Medicine, Big Spring, Texas, 79720, United States|IMD Medical Center, Carrollton, Texas, 75006, United States|Texas Health Physicians Group, Carrollton, Texas, 75010, United States|Cardiovascular Research Institute of Dallas, Dallas, Texas, 75231, United States|North Texas Health Center, Dallas, Texas, 75231, United States|The Heart Center of Dallas, Dallas, Texas, 75235, United States|Global Medical Research, DeSoto, Texas, 75115, United States|The Medical Group of Texas, Fort Worth, Texas, 76104, United States|Texas Health Physicians Group, Fort Worth, Texas, 76107, United States|T&R Clinic, P.A., Haltom City, Texas, 76117, United States|Michele P. Sartori, MD, Houston, Texas, 77030, United States|Grand Medical Care, Katy, Texas, 77494, United States|Team Research Of Central Texas, Killeen, Texas, 76543, United States|Houston Heart and Vascular Associates, Kingwood, Texas, 77339, United States|Grace Research, LLC, Marshall, Texas, 75670, United States|Valley Heart Consultants, McAllen, Texas, 78503, United States|Heart Center, Palo Pinto General Hospital, Mineral Wells, Texas, 76067, United States|Valley Central Research Inc, Mission, Texas, 78572, United States|North Hills Medical Research, Inc, North Richland Hills, Texas, 76180, United States|Grace Research, LLC, Palestine, Texas, 75801, United States|Avant Research Associates, LLC, Port Arthur, Texas, 77640, United States|Santoscoy - Health Texas Research Institute, San Antonio, Texas, 78212, United States|Element Research Group, San Antonio, Texas, 78229, United States|Schnitzler Cardiovascular Consultants, San Antonio, Texas, 78229, United States|San Antonio Endovascular & Heart Institute, San Antonio, Texas, 78268, United States|Acacia Medical Research Institute, Sugar Land, Texas, 77478, United States|Health Plus Clinical Research, Sugar Land, Texas, 77478, United States|Lone Star Heart and Vascular Center, Tomball, Texas, 77375, United States|Northwest Houston Clinical Research, Tomball, Texas, 77375, United States|Hillcrest Family Health Center, Waco, Texas, 76710, United States|Utah Cardiology, P.C., Layton, Utah, 84041, United States|Utah Diabetes Center, Salt Lake City, Utah, 84108, United States|VA Medical Center, White River Junction, White River Junction, Vermont, 05009, United States|Burke Internal Medicine & Research, Burke, Virginia, 22015, United States|Seven Corners Medical Research Center, Falls Church, Virginia, 22044, United States|Hampton Family Practice Research, Hampton, Virginia, 23666, United States|Tidewater Physicians Multispecialty Group, Hampton, Virginia, 23666, United States|Virginia Cardiovascular Associates, Manassas, Virginia, 20109, United States|Manassas Clinical Research Center, Manassas, Virginia, 20110, United States|Tucker Cardiology Associates, P.C., Mechanicsville, Virginia, 23116, United States|TPMG Clinical Research, Newport News, Virginia, 23606, United States|Sentara Norfolk General Hospital, Norfolk, Virginia, 23507, United States|Roanoke Heart Institute PLC, Roanoke, Virginia, 24014, United States|Cardinal Internal Medicine Associates, Woodbridge, Virginia, 22192, United States|Tidewater Physicians Multispecialty Group, Yorktown, Virginia, 23690, United States|Frandsen Family Medicine DBA Sound Medi, Port Orchard, Washington, 98366, United States|Premier Clinical Research, Spokane, Washington, 99202, United States|Kootenai Heart Clinics, LLC, Spokane, Washington, 99204, United States|Northside Internal Medicine, Spokane, Washington, 99208, United States|Northwest Medical Associates, P.S., Vancouver, Washington, 98684, United States|Cardiology Associates of Bellin Health, Green Bay, Wisconsin, 54115, United States|Dean Foundation, Madison, Wisconsin, 53715, United States|University Of Wisconsin, Madison, Wisconsin, 53715, United States|Marshfield Clinic, Marshfield, Wisconsin, 54449, United States|Columbia St. Mary's, Milwaukee, Wisconsin, 53211, United States|Aurora St. Luke's Medical Center, Milwaukee, Wisconsin, 53215, United States|The Medical Arts Health Research Group, North Vancouver, British Columbia, V7M 2H4, Canada|The Medical Arts Health Research Group, Penticton, British Columbia, V2A 5C8, Canada|Winnipeg Clinic, Winnipeg, Manitoba, R3C 0N2, Canada|Bramalea Medical Centre, Brampton, Ontario, L6T 4S5, Canada|Brampton Research Associates, Brampton, Ontario, L6Z 4N5, Canada|Philippe R Beaudry Medicine Professional Corporation, Burlington, Ontario, L7R 4E2, Canada|Vizel Cardiac Research, Cambridge, Ontario, N1R7R1, Canada|Dr. Linda Sinnaeve's Office, Chatham, Ontario, N7L 1C1, Canada|Scisco Clinical Research, Cornwall, Ontario, K6H 4M4, Canada|Dr. Peter Spadafora Health Center, Guelph, Ontario, N1E 5G6, Canada|John Stimac, MD, Hamilton, Ontario, L8L 5G4, Canada|KMH Cardiology & Diagnostics: Hamilton, Hamilton, Ontario, L8P 3A9, Canada|Dr. William Liang, Hamilton, Ontario, L8W3J6, Canada|Source Unique Clinic, Hawkesbury, Ontario, K6A 1A1, Canada|Dr. Ronald Fowlis, Kitchener, Ontario, N2M 5NG, Canada|University Hospital, London, Ontario, N6A 5A5, Canada|Malton Medical Research, Mississauga, Ontario, L4T 4J2, Canada|KMH Cardiology & Diagnostics: Mississauga, Mississauga, Ontario, L5K 2L3, Canada|Sewa Ram Singal Medicine Professional Corporation, Mississauga, Ontario, L5U 0A6, Canada|Newmarket Cardiology Research Group, Newmarket, Ontario, l3y -8c3, Canada|Newmarket Cardiology Research Group, Newmarket, Ontario, L3Y 8C3, Canada|Portage Medical Centre, Niagara Falls, Ontario, I2E6A6, Canada|Humber River Regional Hospital, North York, Ontario, M3N2V6, Canada|Bakbak Medicine Professional Corporation, Oshawa, Ontario, L1H 1B9, Canada|Dr. James Y. Cha, Oshawa, Ontario, L1J2K1, Canada|University Of Ottawa Heart Institute, Ottawa, Ontario, k1y -4w7, Canada|Kawartha Cardiology Clinical Trials, Peterborough, Ontario, K9J0B2, Canada|Steeple Hill Medical Centre, Pickering, Ontario, L1V 2A6, Canada|Sarnia Institute Of Clinical Research, Sarnia, Ontario, N7T 4X3, Canada|Scarborough Cardiology Research, Scarborough, Ontario, M1E5E9, Canada|Scarborough General Hospital Cardiology Research Associates, Scarborough, Ontario, M1PT27, Canada|Milliken Medical Centre, Scarborough, Ontario, M1V5P6, Canada|Canadian Centre for Research on Diabetes, Smith Falls, Ontario, K7A 4W8, Canada|Lake Shore Cardiology, St. Catharines, Ontario, L2S 2Y3, Canada|Sardar Medical Clinic, St. Thomas, Ontario, N5R 2R4, Canada|G.S. Cardiac Lab Medicine Professional Corp, Sudbury, Ontario, P3C 1S8, Canada|Dr. R. Labonte Professional Med Corp, Sudbury, Ontario, P3E 3B8, Canada|Dr. G. Garrioch, Independent Practice, Sudbury, Ontario, P3E 3C6, Canada|Dr. Laurence Gibbs Medicine Professional Corp., Thedford, Ontario, N0M 2N0, Canada|Tillsonburg Medical Centre, Tillsonburg, Ontario, N4G 5A7, Canada|Humber River Hospital, Toronto, Ontario, M3M 0B2, Canada|Sunnybrook Health Sciences Centre, Toronto, Ontario, M4N 3M5, Canada|St. Michael's Hospital, Toronto, Ontario, M5B 1W8, Canada|Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada|Toronto General Hospital, Toronto, Ontario, M5G 2N2, Canada|Weston Road Medical Clinic, Toronto, Ontario, M9N 2A7, Canada|Dr. Nigel Jagan Medicine Professional Corporation, Whitby, Ontario, L1N 2L1, Canada|Dr. Nwadiaro Medicine Professional Corp, Windsor, Ontario, N8X 1L9, Canada|Viacar Recherche Clinique Inc., Brossard, Quebec, J4X1S4, Canada|Ecogene-21, Chicoutimi, Quebec, G7H 7K9, Canada|Q&T Research Chicoutimi, Chicoutimi, Quebec, G7H 7Y8, Canada|Viacar Recherche Clinique Inc., Greenfield Park, Quebec, J4V2G8, Canada|CHUM Hotel-Dieu, Montreal, Quebec, H2W 1T8, Canada|Iucpq, Quebec City, Quebec, G1V 4G5, Canada|ALPHA Recherche Clinique, Québec, Quebec, G3K 2P8, Canada|CardioVasc HR, Saint-Jean-sur-Richelieu, Quebec, j3a-1c3, Canada|ViaCar Recherche Clinique Inc, Saint-Lambert, Quebec, J4P 2H4, Canada|Viacar Recherche Clinique, St. Lambert, Quebec, J4P 2J2, Canada|Hopital Pierre-Le Gardeur, Terrebonne, Quebec, J6V 2H2, Canada|Recherche Clinique Sigma, Inc., Quebec, G1G3Z4, Canada|Instituto Sanacoop, Bayamón, 00961, Puerto Rico|San Juan Bautista School of Medicine, Caguas, 00727, Puerto Rico|Norma S. Severino-Pacheco, MD, Canovanas, 00729, Puerto Rico|Cardiometabolic Research Center, Ponce, 00717, Puerto Rico|Miguel Sosa-Padilla, MD, San Juan, 00926-2832, Puerto Rico|Yolanda Sierra Quinones, MD, Toa Baja, 00949, Puerto Rico
URL: https://clinicaltrials.gov/show/NCT01594333

Drug ID Drug Name Type DrugBank ID Targets Category Latest Progress
D157 Methotrexate small molecule DB00563 Details