| Outcome Measures: |
Primary: Number of Hypoglycemic Events ≥50 mg/dl 15 Minutes AND ≥ 70 mg/dl 30 Minutes After Initial Treatment, 30 minutes | Secondary: Continuous Glucose Monitor (CGM) Minimum Glucose, Event Level, Minimum glucose from CGM data, following each hypoglycemic event with starting BG 50-69 mg/dL, during first hour after start of hypoglycemic event, 60 Minutes|CGM Maximum Glucose, Event Level, Maximum glucose from CGM data, following each hypoglycemic event with starting BG 50-69 mg/dL, during first hour after start of hypoglycemic event, 60 Minutes|CGM Mean Glucose, Event Level, Median (IQR) reported for mean glucose from CGM data, following each hypoglycemic event with starting BG 50-69 mg/dL, during first hour after start of hypoglycemic event, 60 Minutes|CGM Time in Range, Event Level, Percentage of time 70-180 mg/dL from CGM data, following each hypoglycemic event with starting BG 50-69 mg/dL, during first hour after start of hypoglycemic event, 60 Minutes|CGM Time Below 70 mg/dL, Event Level, Percentage of time \<70 mg/dL from CGM data, following each hypoglycemic event with starting BG 50-69 mg/dL, during first hour after start of hypoglycemic event, 60 Minutes|CGM Minimum Glucose, Event Level, Minimum glucose from CGM data, following each hypoglycemic event with starting BG 50-69 mg/dL, during first 2 hours after start of hypoglycemic event, 120 Minutes|CGM Maximum Glucose, Event Level, Maximum glucose from CGM data, following each hypoglycemic event with starting BG 50-69 mg/dL, during first 2 hours after start of hypoglycemic event, 120 Minutes|CGM Mean Glucose, Event Level, Median (IQR) reported for mean glucose from CGM data, following each hypoglycemic event with starting BG 50-69 mg/dL, during first 2 hours after start of hypoglycemic event, 120 Minutes|CGM Time in Range, Event Level, Percentage of time 70-180 mg/dL from CGM data, following each hypoglycemic event with starting BG 50-69 mg/dL, during first 2 hours after start of hypoglycemic event, 120 Minutes|CGM Time Below 70 mg/dL, Percentage of time \<70 mg/dL from CGM data, following each hypoglycemic event with starting BG 50-69 mg/dL, during first 2 hours after start of hypoglycemic event, 120 Minutes|CGM Mean Glucose, Median (IQR) reported for mean glucose from CGM data computed over entire 3 weeks of treatment period, 3 weeks|CGM Time in Range, Percentage of time 70-180 mg/dL from CGM data computed over entire 3 weeks of treatment period, 3 weeks|CGM Time Below 70, Percentage of time \<70 mg/dL from CGM data computed over entire 3 weeks of treatment period, 3 weeks|CGM Coefficient of Variation, Coefficient of Variation from CGM data computed over entire 3 weeks of treatment period, 3 weeks
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| Locations: |
University of Colorado/Barbara Davis Center for Diabetes, Aurora, Colorado, 80045, United States|Yale University of Medicine, New Haven, Connecticut, 06510, United States|Joslin Diabetes Center, Boston, Massachusetts, 02215, United States|SUNY Upstate Medical University, Syracuse, New York, 13210, United States|University of Pennsylvania, Philadelphia, Pennsylvania, 19104, United States
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