| Trial ID: | L6598 |
| Source ID: | NCT01859793
|
| Associated Drug: |
Sitagliptin
|
| Title: |
Effects of Sitagliptin on Endothelial Function in Type 2 Diabetes on Background Metformin Therapy
|
| Acronym: |
|
| Status: |
COMPLETED
|
| Study Results: |
YES
|
| Results: |
https://ClinicalTrials.gov/show/NCT01859793/results
|
| Conditions: |
Diabetes|Atherosclerosis
|
| Interventions: |
DRUG: sitagliptin|DRUG: Placebo
|
| Outcome Measures: |
Primary: Brachial Artery Flow Mediated Dilation, A measurement of endothelial function in humans, Change before and after a single dose (2 hours post) and 8 weeks after daily dosing | Secondary: Circulating Inflammatory Marker ICAM-1, Change before and after acute dose (2 hours) and 8 weeks after daily dosing of medication|Circulating Inflammatory Markers VCAM-1, Change before and after acute dose (2 hours) and 8 weeks after daily dosing of medication
|
| Sponsor/Collaborators: |
Sponsor: Medical College of Wisconsin | Collaborators: Merck Sharp & Dohme LLC
|
| Gender: |
ALL
|
| Age: |
ADULT, OLDER_ADULT
|
| Phases: |
PHASE4
|
| Enrollment: |
38
|
| Study Type: |
INTERVENTIONAL
|
| Study Designs: |
Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
|
| Start Date: |
2013-06
|
| Completion Date: |
2016-07
|
| Results First Posted: |
2016-10-21
|
| Last Update Posted: |
2016-10-21
|
| Locations: |
Medical College of Wisconsin, Milwaukee, Wisconsin, 53226, United States
|
| URL: |
https://clinicaltrials.gov/show/NCT01859793
|
