| Trial ID: | L6640 |
| Source ID: | NCT03566511
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| Associated Drug: |
Diazoxide
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| Title: |
Use of Functional MRI to Assess Functional Hypothalamic Activation in Response to Diazoxide
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| Acronym: |
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| Status: |
SUSPENDED
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| Study Results: |
NO
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| Results: |
|
| Conditions: |
Diabetes Mellitus, Type 2|Glucose, High Blood|Glucose Metabolism Disorders (Including Diabetes Mellitus)
|
| Interventions: |
DRUG: Diazoxide|DRUG: Placebo
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| Outcome Measures: |
Primary: Change in Arterial Spin Labeling (ASL) signal measured using 3T MRI from Baseline to 2 hours post dosing, ASL is a measure of brain blood flow, and an increase in ASL is interpreted as an increase in brain activity. Data is collected at three time points during each of the two visits (pre dosing, 2 hours post dosing, 4 hours post dosing). Data is compared between Non-Diabetic and Type 2 Diabetic Subjects., Baseline, 2 hours post dosing|Change in Arterial Spin Labeling (ASL) signal measured using 3T MRI from 2 hours post dosing to 4 hours post dosing, ASL is a measure of brain blood flow, and an increase in ASL is interpreted as an increase in brain activity. Data is collected at three time points during each of the two visits (pre dosing, 2 hours post dosing, 4 hours post dosing). Data is compared between Non-Diabetic and Type 2 Diabetic Subjects., 2 hours post dosing, 4 hours post dosing |
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| Sponsor/Collaborators: |
Sponsor: Albert Einstein College of Medicine | Collaborators: National Institutes of Health (NIH)|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
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| Gender: |
ALL
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| Age: |
ADULT, OLDER_ADULT
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| Phases: |
PHASE2
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| Enrollment: |
24
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| Study Type: |
INTERVENTIONAL
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| Study Designs: |
Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
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| Start Date: |
2018-06-12
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| Completion Date: |
2024-08
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| Results First Posted: |
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| Last Update Posted: |
2023-06-05
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| Locations: |
Albert Einstein College of Medicine, Bronx, New York, 10461, United States
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| URL: |
https://clinicaltrials.gov/show/NCT03566511
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