| Outcome Measures: |
Primary: Time to initiation of dialysis from enrollment., Averaged time from enrollment to dialysis initiation or death from any cause, whichever comes first. Patients commence dialysis based on the following criteria: 1. Clinical indications of dialysis include medically refractory serum potassium\> 6.5mmol/L, total carbon dioxide (TCO2) \<13mmol/L, eGFR≤5ml/min/1.73m2 (calculated by EPI formula), or the patient is symptomatic (see criteria #2). If these indications remain occur after receiving conservative CKD-related management for 1 week, or if relapse twice within one month, the patient definitely reaches the endpoint. 2. Uremic symptoms include nausea, vomit, malnutrition, pericarditis or pleurisy, volume overload, encephalopathy, bleeding tendency, refractory hypertension, or other symptoms that are likely to be ameliorated by dialysis., From enrollment to dialysis initiation or death.The duration of follow up will be for a maximum of 4 years. | Secondary: all-cause mortality, percentage of subjects who die from any cause during follow-up., From enrollment to dialysis initiation or death.The duration of follow up will be for a maximum of 4 years.|Cardio-cerebro vascular events, Cardio-cerebro vascular events, i.e. cerebral hemorrhage, cerebral infarction, myocardial infarction, acute coronary syndrome, severe arrhythmia, acute heart failure, acute exacerbation of congestive heart failure., From enrollment to dialysis initiation or death.The duration of follow up will be for a maximum of 4 years.|Hospitalization or death caused by severe infection., percentage of subjects who suffer from severe infection events before dialysis initiation.The severe infection will lead to hospitalization or death. Infection events refer to death or hospitalization due to infection., From enrollment to dialysis initiation or death.The duration of follow up will be for a maximum of 4 years.|incidence of severe adverse event/reaction, number of cases of any recorded severe adverse event/reaction per year. Any adverse events/reactions complained of by patients or observed by researchers should be recorded, as well as any newly accompanied disease or aggravation of original symptoms., From enrollment to dialysis initiation or death.The duration of follow up will be for a maximum of 4 years.|Slope of reciprocal serum creatinine, Reciprocal serum creatinine (1/SCr) slope,the serum creatinine was assessed every 2 months., From date of enrollment until the date of first dialysis or date of death from any cause,or the end of study, whichever come first.The duration of follow up will be for a maximum of 4 years.|Nutrition and microinflammation status, Malnutrition Inflammation Score is used to assess nutrition and microinflammation status., From date of enrollment until the date of death from any cause,or the end of study, whichever come first, performed every 6 months.The duration of follow up will be for a maximum of 4 years. | Other: Liver function, aspartate aminotransferase (AST),alanine aminotransferase (ALT), From date of enrollment until the date of death from any cause,or the end of study, whichever come first, performed every 6 months.The duration of follow up will be for a maximum of 4 years.|Complete blood count, Complete blood count, From date of enrollment until the date of death from any cause,or the end of study, whichever come first, performed every 6 months.The duration of follow up will be for a maximum of 4 years.|Routine stool test + occult blood, Routine stool test + occult blood, From date of enrollment until the date of death from any cause,or the end of study, whichever come first, performed every 6 months.The duration of follow up will be for a maximum of 4 years.|Electrocardiogram, Electrocardiogram, From date of enrollment until the date of death from any cause,or the end of study, whichever come first, performed every 6 months.The duration of follow up will be for a maximum of 4 years.|Adverse event/reaction, number of cases of any recorded adverse event/reaction per year., From date of enrollment until the date of death from any cause,or the end of study, whichever come first, performed every 6 months.The duration of follow up will be for a maximum of 4 years.
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| Locations: |
Anhui Provincial Hospital of Chinese Medicine, Hefei, Anhui, 230000, China|China PLA General Hospital, Beijing, Beijing, 100000, China|China-Japan Friendship Hospital, Beijing, Beijing, 100000, China|Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing, Beijing, 100000, China|First Hospital of Peking University, Beijing, Beijing, 100000, China|Guang'anmen Hospital China Academy of traditional Chinese Medicine, Beijing, Beijing, 100000, China|Xiyuan Hospital, Academy of traditional Chinese Medicine, Beijing, Beijing, 100000, China|Third Military Medical University Xinqiao Hospital, Chongqing, Chongqing, 400037, China|General hospital of Guangzhou Military command of PLA, Guangzhou, Guangdong, 510000, China|Guangzhou No.1 People's Hospital, Guangzhou, Guangdong, 510000, China|Huadu District People's Hospital of Guangzhou, Guangzhou, Guangdong, 510000, China|TCM Integrated Hospital of Southern Medical University, Guangzhou, Guangdong, 510000, China|Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, Guangdong, 510120, China|Liuzhou Hospital of traditional Chinese Medicine, Liuzhou, Guangxi, 545000, China|First Affiliated Hospital of Guangxi University Of Chinese Medicine, Nanning, Guangxi, 530000, China|First Affiliated Hospital of Guiyang College of Traditional Chinese Medicine, Guiyang, Guizhou, 550000, China|First Affiliated Hospital of Heilongjiang University Of Chinese Medicine, Ha'erbin, Heilongjiang, 150000, China|Heilongjiang Academy of Traditional Chinese Medicine, Ha'erbin, Heilongjiang, 150000, China|Hubei Provincial Hospital of Chinese Medicine, Wuhan, Hubei, 430000, China|Jiangsu Provincial Hospital of Chinese Medicine, Nanjing, Jiangsu, 210000, China|Shaanxi Provincial Hospital of Chinese Medicine, Xi'an, Shaanxi, 710000, China|Xijing Hospital of The Fourth Military Medical University, Xi'an, Shaanxi, 710000, China|Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, Shanghai, 200000, China|The Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, Shanghai, 200000, China|First hospital of Shanxi Medical University, Taiyuan, Shanxi, 030000, China|Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, 610000, China|First Affiliated Hospital of Tianjin University Of Chinese Medicine, Tianjin, Tianjin, 300000, China|Hangzhou Hospital of Chinese Medicine, Hangzhou, Zhejiang, 310000, China|Tong De Hospital, Zhejiang Province, Hangzhou, Zhejiang, 310000, China
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